FORMULATION, EVALUATION AND COMPARISION OF FAST-DISSOLVING TABLET OF NIMESULIDE BY USING CROSPOVIDONE AS SUPERDISINTEGRANT

Authors

  • Mona Nagar Ranbaxy Laboratories Limited, Industrial Area 3, Dewas, 455001, Madhya Pradesh, India
  • Sanjay K . Singhai Ranbaxy Laboratories Limited, Industrial Area 3, Dewas, 455001, Madhya Pradesh, India
  • Vikram Chopra Ranbaxy Laboratories Limited, Industrial Area 3, Dewas, 455001, Madhya Pradesh, India
  • Kishor Mandage Ranbaxy Laboratories Limited, Industrial Area 3, Dewas, 455001, Madhya Pradesh, India

Abstract

Fast dissolving tablets (FDT) of Nimesulide were prepared by direct compression method. The study was performed by incorporating the superdisintegrant (crospovidone) in 2 %, 4 %, 8 %, 12 % concentration respectively. Four formulations were prepared to assess their efficiency. The optimized batch (Formulation 4) was compared with the available marketed preparation .The optimize batch (Formulation 4) showed excellent in vitro/in vivo dispersion time and drug release as compared to marketed preparation.

 

Keywords:

Nimesulide, direct compression, superdisintegrant

DOI

https://doi.org/10.25004/IJPSDR.2009.010307

References

Amidon GL, Lennernäs H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res.1995; 12: 413–420.

Ali Raguia, Shoukri, Ahmed IS, Shamma RN. In vitro and in vivo evaluation of nimesulide lyophilized orally disintegrating tablets. European journal of pharmaceutics and biopharmaceutic. 2009; 73: 162–171.

Shukla Dali, Chakraborty S, Singh S, Mishra B. Mouth Dissolving Tablets II : An Overview of Evaluation Techniques. Scipharma, 2009; 77: 327–341.

Setty CM, Prasad DVK, Gupta VRM. Development of fast dispersible aceclofenac tablets: Effect of functionality of superdisintegrants. IJPS, 2008; 70: 180–185.

Biscarini L, Patoia L, Favero AD. Nimesulide – A new non-steroidal anti-inflammatory agent. Drugs Today, 1988; 70: 23–27.

Chopra VS, Singhai SK. Formulation and characterization of fast dissolving tablets of nimesulide. IJPCR, 2009; 1(2): 82-84.

Zade PS, Kawtikwar PS, Sakarkar DM. Formulation, evaluation and optimization of fast dissolving tablet containing Tizanidine Hydrochloride. International Journal of PharmTech Research, 2009; 1: 34–42.

Jain CP, Naruka PS. Formulation and evaluation of fast dissolving tablets of valsartan. IJPPS, 2009; 1:219-223.

Published

03-10-2009
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How to Cite

“FORMULATION, EVALUATION AND COMPARISION OF FAST-DISSOLVING TABLET OF NIMESULIDE BY USING CROSPOVIDONE AS SUPERDISINTEGRANT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 1, no. 3, Oct. 2009, pp. 172-5, https://doi.org/10.25004/IJPSDR.2009.010307.

Issue

Volume 1, Issue 3, 2009

Section

Research Article

How to Cite

“FORMULATION, EVALUATION AND COMPARISION OF FAST-DISSOLVING TABLET OF NIMESULIDE BY USING CROSPOVIDONE AS SUPERDISINTEGRANT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 1, no. 3, Oct. 2009, pp. 172-5, https://doi.org/10.25004/IJPSDR.2009.010307.