ANTI HYPERLIPIDEMIC ACTIVITY OF SPONDIAS PINNATA FRUIT EXTRACTS
Abstract
Hyperlipidemia is the greatest risk factor of coronary heart disease. Medicinal plants play a major role in hypolipidemic activity. Literature claims that Saponins are able to reduce hyperlipidemia. Based on high saponin content in herbal plants, Spondias pinnata (SP) was selected and the present study focus on the anti-hyperlipidemic activity of methanolic extracts of fruits of SP against Triton induced hyperlipidemia in rats. SP was administered at a dose of 100 and 200 mg/kg (p.o) to Triton induced hyperlipidemic rats. Fenofibrate was used as reference standard. The statistical analyses were carried out using one way ANOVA followed by Dunnet’s multiple comparisons test. The present investigation shows that all triton induced rats displayed hyperlipidemia as shown by their elevated levels of serum and liver cholesterol, triglyceride, PL, VLDL, LDL and the reduction in the HDL level. It can be concluded that SP 100 and 200 mg/kg treatment was effective in cholesterol, PL, TG, VLDL, LDL and HDL in a dose dependant manner.
Keywords:
Spondias pinnata, Hyperlipidemia, Triglycerides, Lipoproteins.DOI
https://doi.org/10.25004/IJPSDR.2017.090404References
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13. Muramatsu K, Fukuyo M, Hara Y. Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats. Journal of nutritional science and vitaminology. 1986;32(6):613-22.
14. Ding ZH, Chen Y, Zhou M, Fang YZ. Inhibitory effect of green tea polyphenol and morin on the oxidative modification of low density lipoprotein. Chinese Journal of Pharmacology and Toxicology. 1992;6:263-66.
15. Khanna AK, Rizvi F, Chander R. Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats. Journal of Ethnopharmacology. 2002 Sep 1;82(1):19-22.
16. Wilson PW, Abbott RD, Castelli WP. High density lipoprotein cholesterol and mortality. The Framingham Heart Study. Arteriosclerosis, Thrombosis, and Vascular Biology. 1988 Nov 1;8(6):737-41.
17. Warnholtz A, Mollnau H, Oelze M, Wendt M, Münzel T. Antioxidants and endothelial dysfunction in hyperlipidemia. Current hypertension reports. 2001 Feb 1;3(1):53-60.
18. Kumar V, Khan MM, Khanna AK, Singh R, Singh S, Chander R, Mahdi F, Mahdi AA, Saxena JK, Singh RK. Lipid lowering activity of Anthocephalus indicus root in hyperlipidemic rats. Evidence-Based Complementary and Alternative Medicine. 2010;7(3):317-22.
19. Vogel HG, Vogel WH. Drug discovery and evaluation Pharmacological assays. New York: Springer-Verlag Berlin Hiedelberg. 1997, pp. 598.
20. Kumar S, Kumar V, Prakash O. Antidiabetic, hypolipidemic and histopathological analysis of Dillenia indica (L.) leaves extract on alloxan induced diabetic rats. Asian Pacific journal of tropical medicine. 2011 May 1;4(5):347-52.
2. Kaesancini AY, Krauss RM. Cardiovascular disease and hyperlipidemia. Current topics of lipid dynamics 1994; 5: 249. 1994;251.
3. Speight TM, Avery’s. Drug treatment Principles and Practice of clinical Pharmacology and therapeutics. 3rd Edition, ADIS press Ltd, 1987. pp. 599.
4. Gramza A, Korczak J. Tea constituents (Camellia sinensis L.) as antioxidants in lipid systems. Trends in Food Science & Technology. 2005 Aug 31;16(8):351-8.
5. Srivastava AK, Kaushik D, Shrivastava AK, Lal VK. Nephroprotective Ethno-medicinal Action of Selected Indian Medicinal Plants. Int. J. Pharm. Sci. Drug Res. 2017; 9:44-54.
6. Robert WM, Thomas V. Anti hyperlipidemic agent. In: Brunton LL, Lazo SJ, editors. Goodman and Gillman’s the pharmacological basis of therapeutics. 11th ed. New York: Mc Graw-Hill, 2006, pp. 933.
7. Ganga Rao B, Jaya Raju N. Investigation of Hepatoprotective Activity of Spondias Pinnata. International Journal of Pharma Sciences and Research. 2010; 1:193-194.
8. Kirtikar KR, Basu BD. Indian Medicinal Plants. Lalit Mohan Basu Publications. 1935, 11: pp. 39–1141.
9. Mohan S, Nandhakumar N. Role of various flavonoids: Hypotheses on novel approach to treat diabetes. Journal of Medical Hypotheses and Ideas. 2014; 8:1-6.
10. Irwin S. Drug screening and evaluative procedures. Science. 1962 Apr 13;136(3511):123-8.
11. Ecobichon DJ, The Basis of Toxicology Testing, 3rd Edition New York, CRC Press. 1997, pp. 43.
12. Harnafi H, el Houda Bouanani N, Aziz M, Caid HS, Ghalim N, Amrani S. The hypolipidaemic activity of aqueous Erica multiflora flowers extract in Triton WR-1339 induced hyperlipidaemic rats: a comparison with fenofibrate. Journal of ethnopharmacology. 2007 Jan 3;109(1):156-60.
13. Muramatsu K, Fukuyo M, Hara Y. Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats. Journal of nutritional science and vitaminology. 1986;32(6):613-22.
14. Ding ZH, Chen Y, Zhou M, Fang YZ. Inhibitory effect of green tea polyphenol and morin on the oxidative modification of low density lipoprotein. Chinese Journal of Pharmacology and Toxicology. 1992;6:263-66.
15. Khanna AK, Rizvi F, Chander R. Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats. Journal of Ethnopharmacology. 2002 Sep 1;82(1):19-22.
16. Wilson PW, Abbott RD, Castelli WP. High density lipoprotein cholesterol and mortality. The Framingham Heart Study. Arteriosclerosis, Thrombosis, and Vascular Biology. 1988 Nov 1;8(6):737-41.
17. Warnholtz A, Mollnau H, Oelze M, Wendt M, Münzel T. Antioxidants and endothelial dysfunction in hyperlipidemia. Current hypertension reports. 2001 Feb 1;3(1):53-60.
18. Kumar V, Khan MM, Khanna AK, Singh R, Singh S, Chander R, Mahdi F, Mahdi AA, Saxena JK, Singh RK. Lipid lowering activity of Anthocephalus indicus root in hyperlipidemic rats. Evidence-Based Complementary and Alternative Medicine. 2010;7(3):317-22.
19. Vogel HG, Vogel WH. Drug discovery and evaluation Pharmacological assays. New York: Springer-Verlag Berlin Hiedelberg. 1997, pp. 598.
20. Kumar S, Kumar V, Prakash O. Antidiabetic, hypolipidemic and histopathological analysis of Dillenia indica (L.) leaves extract on alloxan induced diabetic rats. Asian Pacific journal of tropical medicine. 2011 May 1;4(5):347-52.
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01-07-2017
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“ANTI HYPERLIPIDEMIC ACTIVITY OF SPONDIAS PINNATA FRUIT EXTRACTS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 9, no. 4, July 2017, pp. 178-81, https://doi.org/10.25004/IJPSDR.2017.090404.
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How to Cite
“ANTI HYPERLIPIDEMIC ACTIVITY OF SPONDIAS PINNATA FRUIT EXTRACTS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 9, no. 4, July 2017, pp. 178-81, https://doi.org/10.25004/IJPSDR.2017.090404.
