ANTIBACTERIAL POLY-HERBAL SEMISOLID FORMULATIONS CONTAINING LEAVES EXTRACTS OF TECTONA GRANDIS, MANGIFERA INDICA AND ANACARDIUM OCCIDENTALE
Abstract
Herbal medicine have become an item of global importance both has medicinal and economical value. Plants used for medicinal purposes long before recorded history. Many plant species have been proved to have antibacterial activity. Thus, the main objective of the study was to formulate and evaluate a poly-herbal semisolid dosage forms using ethanolic extracts of frontal leaves of T. grandis, M. indica and A. occidentale. Formulations were evaluated for its physicochemical properties like color, consistency, pH, spreadability, extrudability and the results were found satisfactory. Antibacterial activity of formulations was studied against S. aureus, E. coli and P. aeruginosa by agar well diffusion method. (E. coli, P. aeruginosa) bacteria. The order of activity was as follows: Water Soluble bases > Gel Bases > Hydrocarbon Bases. The zones of inhibition of poly herbal formulations were in between 23-28 mm which can be comparable with standard formulation 24-29 mm. Activity of the formulations may be due to the presence of alkaloids, flavanoids, phenols and tannins in the extracts. The formulations were found to be very efficacious in all the parameters.
Keywords:
Extraction from leaves, Poly-herbal Ointment, Evaluation, Antibacterial activityDOI
https://doi.org/10.25004/IJPSDR.2016.080505References
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16. Kamath KK, Shabaraya AR. Antibacterial activity of semisolid dosage forms containing extracts of frontal leaves of Tectona grandis (Verbenaceae). Int. J Pharm. and Chem Sci. 2016; 5(4): 239-244.
17. Mishra US, Murthy PN, Pasa G, Nayak RK. Formulation & Evaluation of Herbal Gel containing Methanolic extract of Ziziphus Xylopyrus. Asian J. of Biochemical and Pharm. Res. 2011; 4(1): 207-218.
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20. Patel NA, Patel M, Patel RP. Formulation and Evaluation of Polyherbal gel for Wound Healing. Int. Res. J. of Pharmaceuticals. 2011; 01(1):1-6.
21. Pandey A, Jagtap JV, Polshettiwar SA. Formulation and evaluation of in-vitro antimicrobial activity of gel containing essential oils and effect of polymer on their antimicrobial activity. Int J Pharm Pharm Sci. 2011; 3(1): 234-237.
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23. Majekodunmi SO, Essien AA. Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Cassia alata for skin diseases. Journal of Coastal Life Medicine. 2014; 2(11): 872-875.
24. Jaiswal Y, Naik V, Tatke P, Gabhe1, Vaidya A. Pharmacognostic and Preliminary Phytochemical Investigations of Anacardium Occidentale (Linn.) Leaves. Int. J Pharm Pharm Sci. 2014; 4(3): 625-631.
25. Bharti RP. Studies on antimicrobial activity and phytochemical profile of Mangifera indica Leaf extract. J. of Environmental Sci., Toxicology and Food Tech. 2013; 7(3):74-78.
26. Masibo M, He Q. In vitro antimicrobial activity and the major polyphenol in leaf extract of Mangifera indica L. Malaysian Journal of Microbiology. 2009; 5(2): 73-80.
2. Rajasudha V, Anburaj G, Manikandan R. Effect of various extracts of the leaves of Borreria hispida (Linn) on antibacterial activity. International Journal of Chemical and Pharmaceutical Sciences. 2016; 7(2): 71-75.
3. Prasannabalaji N, Muralitharan G, Sivanandan RN, Kumaran S, Pugazhvendan SR. Antibacterial activities of some Indian traditional plant extracts. Asian pacific journal of tropical disease. 2012; 14:291-295.
4. Periyanayagam K, Jancy GR, Karthikeyan V, Jegadeesh S. Influence of the Leaves of Tectona grandis L. (Verbenaceae) on ex-vivo Porcine Skin Wound Healing Model. American Journal of Pharmaceutical Res. 2014; 2(5):15-27.
5. Khera N and Bhargava S. Phytochemical and pharmacological evaluation of T. grandis Linn. Int J Pharm Pharm Sci. 2013; 5(3):923-927.
6. Kamath KK, Shabaraya AR. Preliminary Phytochemical screening and antibacterial activity of frontal leaves of Tectona grandis (Verbenaceae). World J of pharm. and pharmaceutical sci. 2016; 5(6): 2377-2384.
7. Kumar B, Vijayakumar M, Govindarajan R, Pushpangadan P. Ethno pharmacological approaches to wound healing- Exploring medicinal plants of India. J. of Ethnopharmacol. 2007; 114(2):103-113.
8. Nayeem N and Karvekar MD. Effect of plant stages on analgesic and anti- inflammatory activity of the leaves of T. grandis. Euro J Exp Bio.2012; 2(2)396-399.
9. Venkatanarayana D, Saravana KA, Lakshmi SM. Review on Natural Wound Healing Agents. Int. Journal of Phytopharmacy Research. 2010; Jul 1(1): 1-4.
10. Patil MVK, Kandhare AD, Bhise SD. Pharmacological evaluation of ethanolic extract of Daucuscarota Linn root formulated cream on wound healing using excision and incision wound model. Asian Pac J Trop. Biomed. 2012; 2(2): 646-655.
11. Agnihotri A, Singh V. Effect of alcoholic extract of Tectona grandis Linn Heart wood against oxidative stress and diabetic and oxidative conditions. World J of pharm. and pharmaceutical sci. 2013; 2(1): 367-378.
12. Kumar GC, Ramesh BG, Sudhakar RC. A review on wound healing agents obtained from natural sources. 2011; 1(2): 63-71.
13. Akanksha D, Vikas G, Neetesh KJ, Shailendra S, Neelam B, Dinesh KJ. Formulation and Evaluation of Neomycin Sulphate Ointment containing Natural Wound Healing Agent Curcuma longa. Int. J. of Pharm. Sci. and Drug Res. 2009; 1(2): 116-118.
14. Awad EA, Abdelkareem AM, Hamedelniel EI. Investigation of cream and ointment on antimicrobial activity of M. indica extract. J. of Adv. Pharm. Tech & Res. 2015; 6(2):53-57.
15. Gaikwad DD, Banerjee SK. Pharmacognostical and phyto-physicochemical investigation of Mangifera indica Linn. Int. J. Res. Pharm. Sci., 2013; 4(2):270-275.
16. Kamath KK, Shabaraya AR. Antibacterial activity of semisolid dosage forms containing extracts of frontal leaves of Tectona grandis (Verbenaceae). Int. J Pharm. and Chem Sci. 2016; 5(4): 239-244.
17. Mishra US, Murthy PN, Pasa G, Nayak RK. Formulation & Evaluation of Herbal Gel containing Methanolic extract of Ziziphus Xylopyrus. Asian J. of Biochemical and Pharm. Res. 2011; 4(1): 207-218.
18. Dharamveer, Mishra B, Siddiqui HH. Pharmacognostical and phytochemical studies on Anacardium occidentale Linn. leaves. Res. J of Pharm. and Tech. 2013; 6(1):75-79.
19. Chhetri HP, Yogol N, Sherchan J, Anupa KC, Mansoor S, Thapa P. Formulation and Evaluation Of Antimicrobial Herbal Ointment. Kathmandu University J of Science, Eng. and Tech. 2010; 6(1):102-107.
20. Patel NA, Patel M, Patel RP. Formulation and Evaluation of Polyherbal gel for Wound Healing. Int. Res. J. of Pharmaceuticals. 2011; 01(1):1-6.
21. Pandey A, Jagtap JV, Polshettiwar SA. Formulation and evaluation of in-vitro antimicrobial activity of gel containing essential oils and effect of polymer on their antimicrobial activity. Int J Pharm Pharm Sci. 2011; 3(1): 234-237.
22. Das S, Haldar PK, Pramanik G. Formulation and Evaluation of Herbal Gel containing Clerodendron infortunatum Leaves Extract. Int.J. PharmTech Res. 2011; 3(1):140-143.
23. Majekodunmi SO, Essien AA. Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Cassia alata for skin diseases. Journal of Coastal Life Medicine. 2014; 2(11): 872-875.
24. Jaiswal Y, Naik V, Tatke P, Gabhe1, Vaidya A. Pharmacognostic and Preliminary Phytochemical Investigations of Anacardium Occidentale (Linn.) Leaves. Int. J Pharm Pharm Sci. 2014; 4(3): 625-631.
25. Bharti RP. Studies on antimicrobial activity and phytochemical profile of Mangifera indica Leaf extract. J. of Environmental Sci., Toxicology and Food Tech. 2013; 7(3):74-78.
26. Masibo M, He Q. In vitro antimicrobial activity and the major polyphenol in leaf extract of Mangifera indica L. Malaysian Journal of Microbiology. 2009; 5(2): 73-80.
Published
01-09-2016
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“ANTIBACTERIAL POLY-HERBAL SEMISOLID FORMULATIONS CONTAINING LEAVES EXTRACTS OF TECTONA GRANDIS, MANGIFERA INDICA AND ANACARDIUM OCCIDENTALE”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 8, no. 5, Sept. 2016, pp. 265-8, https://doi.org/10.25004/IJPSDR.2016.080505.
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How to Cite
“ANTIBACTERIAL POLY-HERBAL SEMISOLID FORMULATIONS CONTAINING LEAVES EXTRACTS OF TECTONA GRANDIS, MANGIFERA INDICA AND ANACARDIUM OCCIDENTALE”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 8, no. 5, Sept. 2016, pp. 265-8, https://doi.org/10.25004/IJPSDR.2016.080505.
