CHEMICAL PROFILING BY GC/MS ANALYSIS OF NON-POLAR EXTRACTS OF ERYNGIUM GLAZIOVIANUM (APIACEAE)
Abstract
GC/MS was used as a tool to achieve the chemical profiling of n-hexane extracts from flowers, leaves and stems of plant species Eryngium glaziovianum L. (Apiaceae), an ornamental plant commonly found in several states of Brazil. Gas chromatograms and mass spectra of the constituents of the extracts showed significant differences among the profiles and revealed the presence of the biologically active sesquiterpene b-eudesmol and steroids g-sitosterol and sitostenone as major constituents of flowers, leaves and stems, respectively. These data allow classifying this plant as a source for further isolation of these biologically important substances.
Keywords:
Apiaceae, Eryngium glaziovianum, terpenes, GC-MS techniqueDOI
https://doi.org/10.25004/IJPSDR.2016.080603References
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24. Sundarraja S, Thangama R, Sreevania V, Kaverib K, Gunasekaranb P, Achiramanc S, Kannana S. γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells. Journal of Ethnopharmacology 2012; 141: 803–809.
25. Karthikeyan SC, Velmurugan S, Donio MBS, Michaelbabu M, Thavasimuthu C. Studies on the antimicrobial potential and structural characterization of fatty acids extracted from Sydney rock oyster Saccostrea glomerata. Annals of Clinical Microbiology and Antimicrobials 2014; 13: 332-342.
26. Sivakumar R, Dhivya A. GC-MS Analysis of bioactive compounds on ethyl acetate extract of cordial monoica roxb. leaves. International Journal of Research and Development in Pharmacy and Life Sciences 2015; 4: 1328-1333.
27. Aparna V, Dileep KV, Mandal PK, Karthe P, Sadasvian C, Haridas M. Anti-inflammatory property of n-hexadecanoic acid, structural evidence and kinetic assessment. Chemical Biology Drug Design 2012; 80: 434-439.
28. Konovalova O, Gergel E, Herhel V. GC-MS Analysis of Bioactive Components of Shepherdia argentea (Pursh.) Nutt. from Ukrainian Flora. The Pharma Innovation – Journal 2013; 2: 7-12.
29. Parthipan B, Suky MGT, Mohan VR. GC-MS Analysis of Phytocomponents in Pleiospermium alatum (Wall. ex Wight & Arn.) Swingle, (Rutaceae). Journal of Pharmacognosy and Phytochemistry 2015; 4: 216-222.
30. Phillips S, Rao MRK, Prabhu K, Priya M, Kalaivani S, Ravi A, Dinakar S. Preliminary GC-MS analysis of an Ayurvedic medicine “Kulathadi Kashayam”. Journal of Chemical and Pharmaceutical Research 2015; 7: 393-400.
2. Tavares AC, Loureiro J, Cavaleiro C, Salgueiro L, Canhoto JM., Paiva J. Characterization and distinction of two subspecies of Eryngium duriaei J. Gay ex Boiss., an Iberian endemic Apiaceae, using flow cytometry and essential oils composition. Plant Systematics Evolution 2013; 299: 611–618.
3. Wang P, Yuan W, Deng G, Su Z, Li S. Triterpenoid saponins from Eryngium yuccifolium ‘Kershaw Blue’. Phytochemistry Letters 2013; 6: 306–309.
4. Calvinõ CI, MartÍnez SG, Downie SR. The evolutionary history of Eryngium (Apiaceae, Saniculoideae): Rapid radiations, long distance dispersals, and hybridizations. Molecular Phylogenetics and Evolution 2008; 46: 1129–1150.
5. García-Ruiz I. Contribución al conocimiento Del gênero Eryngium (APIACEAE) em estado de Michoacan, México. Acta Botanica Mexicana 2013; 103: 65-118.
6. Wang P, Su Z, Yuan W, Deng G, Li S. Phytochemical constituents and pharmacological activities of Eryngium L.(Apiaceae). Pharmaceutical Crops 2012; 3: 99–120.
7. Ural IO, Kayalar H, Durmuskahya C, Cavus I, Ozbilgin A. In vivo Antimalarial Activity of Methanol and Water Extracts of Eryngium thorifolium Boiss (Apiaceae Family) against P. berghei in Infected Mice. Tropical Journal Pharmaceutical Research 2014; 13: 1313-1317.
8. Kartal M, Mitaine-Offer AC, Abu-Asaker M, Miyamoto T, Calis I, Wagner H, Lacaille-Dubois MA. Two New Triterpene Saponins from Eryngium campestre. Chemical Pharmaceutical Bulletin 2005; 53: 1318-1320.
9. Kartal M, Mitaine-Offer AC, Thomas Paululat T, Abu-Asaker M, Wagner H, Mirjolet JF, Guilbaud N, Lacaille-Dubois MA. Triterpene Saponins from Eryngium campestre. Journal of Natural Products 2006; 69: 1105-1108.
10. García MD, Sáenz MT, Gómez M A, Fernández MA. Topical Antiinflammatory Activity of Phytosterols Isolated from Eryngium foetidum on Chronic and Acute Inflammation Models. Phytotherapy Research 1999; 13: 78–80.
11. Jaghabir M. Hypoglycemic effects of Eryngium Creticum. Archives Pharmacal Research 1991; 14: 295-297.
12. Fiaschi P, Cota MRC. Apiaceae in Lista de Espécies da Flora do Brasil. Jardim Botânico do Rio de Janeiro. http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB102509. [Consulted Octubre 10, 2015].
13. Adams, R. P.; Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry, Allured Publishing Corp.: Carol Stream, USA, 2007.
14. Nojima H, Kimura I, Kimura M. Succinylcholine with β-eudesmol on acetylcholine-activated channel activity at endplates of single muscle cells of adult mice. Brain Research 1992; 575: 337-340.
15. Kimura M, Nojima H, Muroi M, Kimura I. Mechanism of the blocking action of β-eudesmol on the nicotinic acetylcholine receptor channel in mouse skeletal muscles. Neuropharmacology 1991; 30: 835-841.
16. Tsuneki H, Ma EL, Kobayashic S, Sekizakia N, Maekawaa K, Sasaokaa T, Wangb MW, Kimuraa I. Antiangiogenic activity of β-eudesmol in vitro and in vivo. European Journal of Pharmacology 2005; 512: 105–115.
17. Su YC, Ho CL.Composition and Two Activities of the Leaf Essential Oil of Litsea acuminata (Blume) Kurata from Taiwan. Records of Natural Products 2013; 7: 27-34.
18. Ali A, Tabanca N, Demirci B, Blythe EK, Ali Z, K. Baser HC, Khan IA. Chemical Composition and Biological Activity of Four Salvia Essential Oils and Individual Compounds against Two Species of Mosquitoes. Journal Agricultural and Food Chemistry 2015; 63: 447–456.
19. Verma M, Sharma S, Prasad R. Biological alternatives for termite control: A review. International Biodeterioration & Biodegradation 2009; 63: 959–972.
20. Yinusa I, George NI, Shuaibu UOA, Ayo RG. Bioactivity of stigmasterol isolated from the aerial part of Spillanthes acmella (Murr) on selected microorganism. International Journal Current Microbiology Applied Science 2014; 3: 475-479.
21. Dandekar R, Fegade B, Bhaskar VH. GC-MS analysis of phytoconstituents in alcohol extract of Epiphyllum oxypetalum leaves. Journal of Pharmacognosy and Phytochemistry 2015; 4: 149-154
22. Prachayasittikul S, Suphapong S, Worachartcheewan A, Lawung R, Ruchirawat S, Prachayasittikul V. Bioactive Metabolites from Spilanthes acmella Murr. Molecules 2009; 14: 850-867.
23. Ingert N, Bombarda I, Herbette G , Faure R, Moretti C, Raharivelomanana P. Oleodaphnoic Acid and Coriaceol, Two New Natural Products from the Stem Bark of Wikstroemia coriácea. Molecules 2013; 18: 2988-2996.
24. Sundarraja S, Thangama R, Sreevania V, Kaverib K, Gunasekaranb P, Achiramanc S, Kannana S. γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells. Journal of Ethnopharmacology 2012; 141: 803–809.
25. Karthikeyan SC, Velmurugan S, Donio MBS, Michaelbabu M, Thavasimuthu C. Studies on the antimicrobial potential and structural characterization of fatty acids extracted from Sydney rock oyster Saccostrea glomerata. Annals of Clinical Microbiology and Antimicrobials 2014; 13: 332-342.
26. Sivakumar R, Dhivya A. GC-MS Analysis of bioactive compounds on ethyl acetate extract of cordial monoica roxb. leaves. International Journal of Research and Development in Pharmacy and Life Sciences 2015; 4: 1328-1333.
27. Aparna V, Dileep KV, Mandal PK, Karthe P, Sadasvian C, Haridas M. Anti-inflammatory property of n-hexadecanoic acid, structural evidence and kinetic assessment. Chemical Biology Drug Design 2012; 80: 434-439.
28. Konovalova O, Gergel E, Herhel V. GC-MS Analysis of Bioactive Components of Shepherdia argentea (Pursh.) Nutt. from Ukrainian Flora. The Pharma Innovation – Journal 2013; 2: 7-12.
29. Parthipan B, Suky MGT, Mohan VR. GC-MS Analysis of Phytocomponents in Pleiospermium alatum (Wall. ex Wight & Arn.) Swingle, (Rutaceae). Journal of Pharmacognosy and Phytochemistry 2015; 4: 216-222.
30. Phillips S, Rao MRK, Prabhu K, Priya M, Kalaivani S, Ravi A, Dinakar S. Preliminary GC-MS analysis of an Ayurvedic medicine “Kulathadi Kashayam”. Journal of Chemical and Pharmaceutical Research 2015; 7: 393-400.
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01-11-2016
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“CHEMICAL PROFILING BY GC MS ANALYSIS OF NON-POLAR EXTRACTS OF ERYNGIUM GLAZIOVIANUM (APIACEAE)”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 8, no. 6, Nov. 2016, pp. 291-4, https://doi.org/10.25004/IJPSDR.2016.080603.
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Copyright (c) 2016 A. C. J. S. Wuillda, M. Trovó, R. C. C. Martins
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How to Cite
“CHEMICAL PROFILING BY GC MS ANALYSIS OF NON-POLAR EXTRACTS OF ERYNGIUM GLAZIOVIANUM (APIACEAE)”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 8, no. 6, Nov. 2016, pp. 291-4, https://doi.org/10.25004/IJPSDR.2016.080603.
