ANTI-ARTHRITIC ACTIVITY OF ETHANOLIC EXTRACT OF ROOT OF MOMORDICA CHARANTIA AGAINST FCA INDUCED ARTHRITIS
Abstract
The present investigation is aimed to evaluate anti-arthritic activity of the ethanol extract of root of Momordica charantia (EEMR) by using Freund’s complete adjuvant (FCA) induced arthritis model which is a extensively used model for in-vivo study of anti-arthritic activity. Arthritis assessment was carried out on basis of parameters i.e. arthritis score, joint diameter and paw volume. The standard drug was diclofenac sodium. The findings of present study showed that EEMR in dose of 400 mg/kg produced more significant reduction in arthritis score, joint diameter and paw volume as compare to 200 mg/kg. On the basis of results, it can be concluded that EEMR showed significant anti-arthritic activity. It may be due to presence of phytocompounds such as flavonoids, alkaloids, tannins etc.
Keywords:
Momordica charantia, Anti-arthritic activity, Freund’s complete adjuvant, Rheumatoid arthritisDOI
https://doi.org/10.25004/IJPSDR.2016.080604References
1. Gautam RK, Sharma S, Sharma K. Comparative Evaluation of Anti-arthritic activity of Pongamia pinnata and Punica granatum: An In-vitro study. International Journal of Pharmacy and Pharmaceutical Sciences. 2013; 5(4):721-4.
2. Ramasamy S, Rajendran V, Rangaraj R, Chinnayan V. Effect of Elaeocarpus sphaericus in freund’s complete adjuvant (FCA) induced rheumatoid arthritis in albino rats. Indo-global Research Journal of Pharmaceutical Sciences. 2012; 3(2):378-82.
3. Gautam RK, Sharma S, Sharma K. Comparative Evaluation of Anti-arthritic activity of Salvadora persica linn. and Asparagus racemosus willd: An In-vitro study. Indo American Journal of Pharmaceutical Research. 2013; 3(10):8222-7
4. Grover JK, Yadav SP. Pharmacological Actions and Potential Uses of Momordica charantia: A Review. Journal of Ethnopharmacology. 2004; 93:123–32.
5. Desai S, Tatke P. Charantin an Important Lead Compound from Momordica charantia for the Treatment of Diabetes. Journal of Pharmacognosy and Phytochemistry. 2015; 3(6):163-6.
6. Kumar DS, Sharathnath KV, Yogeswaran P, Harani A, Sudhakar K, Sudha P, Banji D. A Medicinal Potency of Momordica charantia. International Journal of Pharmaceutical Sciences Review and Research. 2010; 1(2):95-100.
7. Ahmad N, Hasan N, Ahmad Z, Zishan M, Zohrameena S. Momordica charantia: for Traditional Uses and Pharmacological Actions. Journal of Drug Delivery and Therapeutics, 2016; 6(2):40-44.
8. Soni L, Gautam RK, Jain PK. Evaluation of Anti-arthritic Activity of Momordica charantia Root by In-vitro Models: The Pharmaceutical and Chemical Journal, 2016; 3(2):173-7.
9. Khandelwal KR. Practical Pharmacognosy Technique and Experiments. Nirali Prakashan, Pune, 2007.
10. Patil MVK, Kandhareb AD, Bhise SD. Anti-arthritic and Anti-inflammatory Activity of Xanthium srtumarium L. Ethanolic Extract in Freund’s Complete Adjuvant induced Arthritis. Biomedicine & Aging Pathology. 2012; 2(1): 6–15.
11. Choudhary M, Kumar V, Gupta PK, Singh S. Anti-arthritic activity of Barleria prionitis Linn. Leaves in Acute and Chronic Models in Sprague Dawley Rats. Bulletin of Faculty of Pharmacy, Cairo University. 2014; 52:199-209.
12. Mail SM, Sinnathambi A, Kapase CU, Bodhankar SL. Anti-Arthritic Activity of Standardised Extract of Phyllanthus Amarus in Freund’s Complete Adjuvant Induced Arthritis. Biomedicine & Aging pathology. 2011; 1: 185-190.
13. Kadam P, Bodhankar SL. Antiarthritic Activity of Ethanolic Seed Extracts of Diplocyclos palmatus (L) C. Jeffrey in Experimental Animals. Der Pharmacia Lettre. 2013; 5(3) 233-42.
14. Amresha G, Singh PN, Rao ChV. Antinociceptive and Antiarthritic Activity of Cissampelos pareira roots. Journal of Ethnopharmacology. 2007; 111(3): 531–6.
2. Ramasamy S, Rajendran V, Rangaraj R, Chinnayan V. Effect of Elaeocarpus sphaericus in freund’s complete adjuvant (FCA) induced rheumatoid arthritis in albino rats. Indo-global Research Journal of Pharmaceutical Sciences. 2012; 3(2):378-82.
3. Gautam RK, Sharma S, Sharma K. Comparative Evaluation of Anti-arthritic activity of Salvadora persica linn. and Asparagus racemosus willd: An In-vitro study. Indo American Journal of Pharmaceutical Research. 2013; 3(10):8222-7
4. Grover JK, Yadav SP. Pharmacological Actions and Potential Uses of Momordica charantia: A Review. Journal of Ethnopharmacology. 2004; 93:123–32.
5. Desai S, Tatke P. Charantin an Important Lead Compound from Momordica charantia for the Treatment of Diabetes. Journal of Pharmacognosy and Phytochemistry. 2015; 3(6):163-6.
6. Kumar DS, Sharathnath KV, Yogeswaran P, Harani A, Sudhakar K, Sudha P, Banji D. A Medicinal Potency of Momordica charantia. International Journal of Pharmaceutical Sciences Review and Research. 2010; 1(2):95-100.
7. Ahmad N, Hasan N, Ahmad Z, Zishan M, Zohrameena S. Momordica charantia: for Traditional Uses and Pharmacological Actions. Journal of Drug Delivery and Therapeutics, 2016; 6(2):40-44.
8. Soni L, Gautam RK, Jain PK. Evaluation of Anti-arthritic Activity of Momordica charantia Root by In-vitro Models: The Pharmaceutical and Chemical Journal, 2016; 3(2):173-7.
9. Khandelwal KR. Practical Pharmacognosy Technique and Experiments. Nirali Prakashan, Pune, 2007.
10. Patil MVK, Kandhareb AD, Bhise SD. Anti-arthritic and Anti-inflammatory Activity of Xanthium srtumarium L. Ethanolic Extract in Freund’s Complete Adjuvant induced Arthritis. Biomedicine & Aging Pathology. 2012; 2(1): 6–15.
11. Choudhary M, Kumar V, Gupta PK, Singh S. Anti-arthritic activity of Barleria prionitis Linn. Leaves in Acute and Chronic Models in Sprague Dawley Rats. Bulletin of Faculty of Pharmacy, Cairo University. 2014; 52:199-209.
12. Mail SM, Sinnathambi A, Kapase CU, Bodhankar SL. Anti-Arthritic Activity of Standardised Extract of Phyllanthus Amarus in Freund’s Complete Adjuvant Induced Arthritis. Biomedicine & Aging pathology. 2011; 1: 185-190.
13. Kadam P, Bodhankar SL. Antiarthritic Activity of Ethanolic Seed Extracts of Diplocyclos palmatus (L) C. Jeffrey in Experimental Animals. Der Pharmacia Lettre. 2013; 5(3) 233-42.
14. Amresha G, Singh PN, Rao ChV. Antinociceptive and Antiarthritic Activity of Cissampelos pareira roots. Journal of Ethnopharmacology. 2007; 111(3): 531–6.
Published
01-11-2016
Statistics
Abstract Display: 391 
PDF Downloads: 477
Dimension Badge
How to Cite
“ANTI-ARTHRITIC ACTIVITY OF ETHANOLIC EXTRACT OF ROOT OF MOMORDICA CHARANTIA AGAINST FCA INDUCED ARTHRITIS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 8, no. 6, Nov. 2016, pp. 295-8, https://doi.org/10.25004/IJPSDR.2016.080604.
Issue
Section
Research Article
How to Cite
“ANTI-ARTHRITIC ACTIVITY OF ETHANOLIC EXTRACT OF ROOT OF MOMORDICA CHARANTIA AGAINST FCA INDUCED ARTHRITIS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 8, no. 6, Nov. 2016, pp. 295-8, https://doi.org/10.25004/IJPSDR.2016.080604.
