MODELING THE ORAL CAVITY WITH MUCOADHESIVE DRUG DELIVERY SYSTEMS - A POTENTIAL ALTERNATIVE TO CONVENTIONAL THERAPY
Abstract
Oral mucosal drug delivery system is widely applicable as novel site for administration of drug and controlled release action by preventing first pass metabolism and enzymatic degradation due to GI microbial flora. The oral cavity represents a challenging area to develop an effective drug delivery modelling. This arises due to the various inherent functions of the oral cavity (eating, swallowing, speaking, chewing), as well as the presence of the fluid that is involved in all these activities, saliva. This fluid is continually secreted into and then removed from the mouth. Oral Mucosa drug delivery system provides local and systemic action. The delivery of drugs through the buccal mucosa has attracted much research interest over the past two decades and numerous approaches, both conventional and complex, have been developed in an attempt to deliver a variety of pharmaceutical compounds via the buccal route. To outline the progress in the in vitro and in vivo modeling of Mucosal drug delivery and provide a critical review of currently used methods. The purpose of this review is to represent the modeling of oral cavity with Mucoadhesive drug delivery systems and clarify the potential alternative to conventional therapy.
Keywords:
Mucoadhesion, Penetration enhancers, buccal epithelium, Vascularity absorption.DOI
https://doi.org/10.25004/IJPSDR.2017.090603References
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8. Humphrey SP, Williamson RT. A review of saliva: normal composition, flow and function. J. Prosthet. Den. 2001; 85: 162-169.
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11. Onchel G. Formulation of oral mucosal drug delivery systems for systemic delivery of bioactive materials. Adved drug delivery systems. 1998; 13:75-87.
12. Galey WR, Lonsdale HK, Nacht S. The in vitro permeability of skin and buccal mucosa to selected drugs and tritiated water. J. Invest. Dermat 1976; 67:713-717.
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15. Hearnden V, Sankar V, Hull K, Juras DV, Greenberg M, Ross Kerr A, Lockhart PB, Patton LL, Porter S, Thornhill MA. A New developments and opportunities in oral mucosal drug delivery for local and systemic disease. Advanced Drug Delivery Reviews. 2012; 64:16-28.
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17. Steward A, Bayley DL, Howes C. The effect of enhancers on the buccal absorption of hybrid (BDBB) alpha-interferom. Int. J. Pharm. 1994; 104:145-149.
18. Maniruzzaman M, Boateng JS, Snowden MJ, Douroumis D. A review of hot-melt extrusion: process technology to pharmaceutical products. Expert Opin Drug Deliv. 2016; 13(4):493-506.
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20. Buanz ABM, Saunders MH, Basit AW, Gaisford S. Preparation of personalized-dose salbutamol sulphate oral films with thermal ink-jet printing. Pharm Res. 2011; 28:2386–92.
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24. Park J-B, Prodduturi S, Morott J, Kulkarni VI, Jacob MR, Khan SI, et al. Development of an antifungal denture adhesive film for oral candidiasis utilizing hot melt extrusion technology. Expert Opin Drug Deliv. 2015; 12:1–13.
25. Scoutaris N, Alexander MR, Gellert PR, Roberts CJ. Inkjet printing as a novel medicine formulation technique. J Control Release. 2011; 156:179–85.
26. Repka MA, Munjal M, ElSohly MA, Ross SA. Temperature stability and bioadhesive properties of δ9-tetrahydrocannabinol incorporated hydroxypropylcellulose polymer matrix systems. Drug Dev Ind Pharm. 2006; 32:21-32.
27. Arrabito G, Pignataro B. Inkjet printing methodologies for drug screening. Anal Chem. 2010; 82:3104–7.
28. Krampe R, Visser JC, Frijlink HW, Breitkreutz J, Woerdenbag HJ, Preis M. Oromucosal film preparations: points to consider for patient centricity and manufacturing processes. Expert Opin Drug Deliv. 2015; 1–14.
29. Zhang Y, Cui L, Che X, Zhang H, Shi N, Li C, Chen Y, Kong W. Zein-based films and their usage for controlled delivery: origin, classes and current landscape. J Control Release. 2015; 206:206-19.
30. Shinkar DM, Dhake AS, Setty CM. Drug delivery from the oral cavity: a focus on mucoadhesive buccal drug delivery systems. J Pharm Sci Technol. 2012; 66(5):466– 500.
31. Boddupalli B, Mohammed Z, Nath R, Banji D. Mucoadhesive drug delivery system: An overview. J Adv Pharm Technol Res. 2010; 1(4):381.
32. Dodou D, Breedveld P, Mucoadhesives in the gastrointestinal tract: Revisiting the literature for novel applications. Eur J Pharm Biopharm. 2005; 60(1):1–16.
33. Derjaguin B V, Toporov YP, Muller VM, Aleinikova IN. On the relationship between the electrostatic and the molecular component of the adhesion of elastic particles to a solid surface. J Colloid Interface Sci. 1977; 58(3):528–33.
34. Edsman K, Hägerström H. Pharmaceutical applications of mucoadhesion for the nonoral routes. J Pharm Pharmacol. 2005; 57(1):3–22.
35. Huang Y, Leobandung W, Foss A, Peppas NA. Molecular aspects of muco- and bioadhesion: Tethered structures and site-specific surfaces. J Control Release. 2000; 65(1–2):63–71.
36. Good RJ. Surface free energy of solids and liquids: Thermodynamics, molecular forces, and structure. J Colloid Interface Sci. 1977; 59(3):398–419.
37. Kinloch AJ. The science of adhesion - Part 1 Surface and interfacial aspects. J Mater Sci. 1980; 15(9):2141–66.
38. Peppas NA, Sahlin JJ. Hydrogels as mucoadhesive and bioadhesive materials: A review. Biomaterials. 1996; 17(16):1553–61.
39. Lee L-H. The chemistry and physics of solid adhesion. In: Fundamentals of Adhesion. New York: Plenum Press; 1991. pp. 454.
40. Ahagon A, Gent AN. Effect of interfacial bonding on the strength of adhesion. J Polym Sci Polym Phys Ed. 1975; 13(7):1285–300.
2. Shaikh TA, Shinkar DM, Saudagar RB. Review: Polymers used in the Mucoadhesion Drug Delivery System. International journal of pharma research & review. 2016; 5(5):45-53.
3. Khan AB, Mahamana R, Pal E. Review on Mucoadhesive Drug Delivery System: Novel approaches in modern era. RGUHS J Pharm Sci. 2014; 4(4): 128-141.
4. Chatterjee B, Amalina N, Sengupta P, Mandal UK. Mucoadhesive polymers and their mode of action: a recent update. Journal of applied pharmaceutical science. 2017; 7(05): 195-203.
5. Singh R, Sharma D, Garg R. Review on mucoadhesive drug delivery system with special emphasis on buccal route: An important tool in designing of novel controlled drug delivery system for the effective delivery of pharmaceuticals. J Dev Drugs. 2017; 6: 169.
6. Laffleur F. Mucoadhesive Polymers for Buccal Drug Delivery. Drug Dev Ind Pharm. 2014; 40(5):591-598.
7. Patel KV, Patel ND, Dodiya HD, Shelat PK. BuccalBioadhesive Drug Delivery System; An overview. International Journal of Pharmaceutical and Biological Archeives. 2011; 2(2):600-609.
8. Humphrey SP, Williamson RT. A review of saliva: normal composition, flow and function. J. Prosthet. Den. 2001; 85: 162-169.
9. Shojaei AH. Buccal Mucosa as A Route for Systemic Drug Delivery: A Review. J Pharm Pharm Sci. 1998; 1(1):15-30.
10. Hoogstraate JAJ, WWertz PW. Drug delivery via the buccal mucosa. Pharmaceutical Science & Technology Today. 1998; 1(7):309-316.
11. Onchel G. Formulation of oral mucosal drug delivery systems for systemic delivery of bioactive materials. Adved drug delivery systems. 1998; 13:75-87.
12. Galey WR, Lonsdale HK, Nacht S. The in vitro permeability of skin and buccal mucosa to selected drugs and tritiated water. J. Invest. Dermat 1976; 67:713-717.
13. Hoogstraate AJ, Cullander C, Nagelkerke JF, Senel S, Verhoef JC, Junginger HE, Bodde HE. Diffusion rates and transport pathways of fluorescein isothiocyanate (FITC)- labeled model compounds through buccal epithelium. Pharm. Res. 1994; 11: 83-89.
14. Magnusson BM, Walters KA, Roberts MS. Veterinary drug delivery: potential for skin penetration enhancement. Advanced Drug Delivery Reviews. 2001; 50: 205-227.
15. Hearnden V, Sankar V, Hull K, Juras DV, Greenberg M, Ross Kerr A, Lockhart PB, Patton LL, Porter S, Thornhill MA. A New developments and opportunities in oral mucosal drug delivery for local and systemic disease. Advanced Drug Delivery Reviews. 2012; 64:16-28.
16. Nicolazzo JA, Reed BL, Finnin BC. Buccal penetration enhancers-How do they really work. Journal of Controlled Release. 2005; 105:1-15.
17. Steward A, Bayley DL, Howes C. The effect of enhancers on the buccal absorption of hybrid (BDBB) alpha-interferom. Int. J. Pharm. 1994; 104:145-149.
18. Maniruzzaman M, Boateng JS, Snowden MJ, Douroumis D. A review of hot-melt extrusion: process technology to pharmaceutical products. Expert Opin Drug Deliv. 2016; 13(4):493-506.
19. Parikh T, Gupta SS, Meena AK, Vitez I, Mahajan N, Serajuddin ATM. Application of film-casting technique to investigate drug-polymer miscibility in solid dispersion and hot-melt extrudate. J Pharm Sci. 2015; 104:2142–52.
20. Buanz ABM, Saunders MH, Basit AW, Gaisford S. Preparation of personalized-dose salbutamol sulphate oral films with thermal ink-jet printing. Pharm Res. 2011; 28:2386–92.
21. Londhe VY, Umalkar KB. Formulation development and evaluation of fast dissolving film of telmisartan. Indian J Pharm Sci. 2012; 74:122–6.
22. Lindén M. Hot-melt extrusion of modified release pellets influence of the formulation and extrusion process on extended-and enteric release profile. Master of Science Thesis in the Master Degree Programme, Biotechnology, Chalmers University of Technology, Gothenburg, Sweden, 2012.
23. Sahni J, Raj S, Ahmad FJ, Khar RK. Design and in vitro characterization of buccoadhesive drug delivery system of insulin. Indian J Pharm Sci. 2008; 70:61–5.
24. Park J-B, Prodduturi S, Morott J, Kulkarni VI, Jacob MR, Khan SI, et al. Development of an antifungal denture adhesive film for oral candidiasis utilizing hot melt extrusion technology. Expert Opin Drug Deliv. 2015; 12:1–13.
25. Scoutaris N, Alexander MR, Gellert PR, Roberts CJ. Inkjet printing as a novel medicine formulation technique. J Control Release. 2011; 156:179–85.
26. Repka MA, Munjal M, ElSohly MA, Ross SA. Temperature stability and bioadhesive properties of δ9-tetrahydrocannabinol incorporated hydroxypropylcellulose polymer matrix systems. Drug Dev Ind Pharm. 2006; 32:21-32.
27. Arrabito G, Pignataro B. Inkjet printing methodologies for drug screening. Anal Chem. 2010; 82:3104–7.
28. Krampe R, Visser JC, Frijlink HW, Breitkreutz J, Woerdenbag HJ, Preis M. Oromucosal film preparations: points to consider for patient centricity and manufacturing processes. Expert Opin Drug Deliv. 2015; 1–14.
29. Zhang Y, Cui L, Che X, Zhang H, Shi N, Li C, Chen Y, Kong W. Zein-based films and their usage for controlled delivery: origin, classes and current landscape. J Control Release. 2015; 206:206-19.
30. Shinkar DM, Dhake AS, Setty CM. Drug delivery from the oral cavity: a focus on mucoadhesive buccal drug delivery systems. J Pharm Sci Technol. 2012; 66(5):466– 500.
31. Boddupalli B, Mohammed Z, Nath R, Banji D. Mucoadhesive drug delivery system: An overview. J Adv Pharm Technol Res. 2010; 1(4):381.
32. Dodou D, Breedveld P, Mucoadhesives in the gastrointestinal tract: Revisiting the literature for novel applications. Eur J Pharm Biopharm. 2005; 60(1):1–16.
33. Derjaguin B V, Toporov YP, Muller VM, Aleinikova IN. On the relationship between the electrostatic and the molecular component of the adhesion of elastic particles to a solid surface. J Colloid Interface Sci. 1977; 58(3):528–33.
34. Edsman K, Hägerström H. Pharmaceutical applications of mucoadhesion for the nonoral routes. J Pharm Pharmacol. 2005; 57(1):3–22.
35. Huang Y, Leobandung W, Foss A, Peppas NA. Molecular aspects of muco- and bioadhesion: Tethered structures and site-specific surfaces. J Control Release. 2000; 65(1–2):63–71.
36. Good RJ. Surface free energy of solids and liquids: Thermodynamics, molecular forces, and structure. J Colloid Interface Sci. 1977; 59(3):398–419.
37. Kinloch AJ. The science of adhesion - Part 1 Surface and interfacial aspects. J Mater Sci. 1980; 15(9):2141–66.
38. Peppas NA, Sahlin JJ. Hydrogels as mucoadhesive and bioadhesive materials: A review. Biomaterials. 1996; 17(16):1553–61.
39. Lee L-H. The chemistry and physics of solid adhesion. In: Fundamentals of Adhesion. New York: Plenum Press; 1991. pp. 454.
40. Ahagon A, Gent AN. Effect of interfacial bonding on the strength of adhesion. J Polym Sci Polym Phys Ed. 1975; 13(7):1285–300.
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01-11-2017
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“MODELING THE ORAL CAVITY WITH MUCOADHESIVE DRUG DELIVERY SYSTEMS - A POTENTIAL ALTERNATIVE TO CONVENTIONAL THERAPY”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 9, no. 6, Nov. 2017, pp. 299-07, https://doi.org/10.25004/IJPSDR.2017.090603.
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How to Cite
“MODELING THE ORAL CAVITY WITH MUCOADHESIVE DRUG DELIVERY SYSTEMS - A POTENTIAL ALTERNATIVE TO CONVENTIONAL THERAPY”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 9, no. 6, Nov. 2017, pp. 299-07, https://doi.org/10.25004/IJPSDR.2017.090603.
