DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE FLOATING MICROSPHERES CONTAINING ROPINIROLE HCL
Abstract
Current investigation was to develop gastro retentive floating microsphere for Ropinirole. These microspheres of Ropinirole were prepared by ionic gelation method with an aim of increasing the gastric residence time and for controlled release. Sodium alginate, HPMCK15, Gaur gum was used as polymers. Sodium bicarbonate was used as the gas-forming gent. Prepared microspheres were characterized for micromeretic properties, entrapment efficiency, buoyancy study, SEM analysis, FTIR, and in vitro dissolution studies. Among 14 formulations F12 was found to be optimized and based on the evaluation parameters. The % buoyancy, % yield, % entrapment efficiency and swelling index of F12 formulation was 94.50, 97.58, 98.10% and 96.14%, respectively. The Cumulative % drug release of F12 formulation was 98.16 ± 5.15 in 12 h when compared with marketed product 90.16 ± 5.00 in 12 h. SEM studies showed the particles were in spherical shape. Hence the formulated floating Ropinirole microspheres may establish to be potential candidate for safe and effective sustained drug delivery and improve the bioavailability in the effective management of Parkinson’s disease.
Keywords:
Floating microspheres, Gaur Gum, HPMC K15M, Sodium bicarbonate, SEM, in vitro diffusion studiesDOI
https://doi.org/10.25004/IJPSDR.2018.100309References
2. Bulgarelli E, Forni F, Bernabei MT. Effect of matrix composition and process conditions on casein-gelatin beads floating properties. Int J Pharm. 2000; 198:157-165.
3. Joseph J, Daisy P, George BJ, Praveen raj R, Thomas N, Carla B. Formulation and evaluation of floating microspheres of Pantoprazole Sodium. IJPPR. 2015; 4:136-147.
4. Jani JH, Prajapati AJ, Shah DK, Singh SK. Formulation and Evaluation of Buccal Tablet of Ropinirole Hydrochloride. Pharma tech. 2012; 4:527.
5. Moffat AC, Osselton MD, Widdop B. Clarke’s Analysis of Drugs and Poisons. Pharmaceutical Press London. 2004; 3:1543.
6. Najmuddin M, Hafiz RF, Nizamuddin M, Khalid MS. Development and evaluation of ketoprofen mini-matrices as sustained release formulation Int. J. Chem. Sci.2009; 7(3): 2122-2134.
7. Pande AV, Vaidya PD, Arora A, Dhoka MV. In-vitro and In-vivo evaluation of ethyl cellulose floating microspheres of cefpodoxime proxetil. International Journal of Pharmaceutical and Biomedical Research. 2010; 1(4):122-128.
8. Gadad A, Chirag N, Patel K, Dandagi P, Vinayak M. Formulation and evaluation of floating microspheres of captopril for prolonged gastric residence time. Indian Journal of Novel Drug Delivery.2011; 3(1): 17-23.
9. Patel SS, Ray S, Thakur RS. Formulation and Evaluation of Floating Drug Delivery System containing Clarithromycin for Helicobacter pylori. Acta Poloniae Pharmaceutica - Drug Research. 2006; 63(1): 53-61.
10. Patil HS, Patil MP, Tekade BW, Thakare VM, Vijay R. Formulation and In-vitro Evaluation of Floating Microspheres of Acyclovir. Arch Pharm Sci & Res. 2009; 1(1): 194 -198.
11. Srivastava AK, Ridhurkar DN RD, Wadhwa S. Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation. Acta Pharm. 2005; 55: 277–285.
12. Vueba ML, Carvalho LB, Veiga F, Sousa JJ, Pina ME. Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets. Eur J Pharm and Biopharm. 2004; 58: 51-59.
13. Ninan M, Lu X, Qifang W, Xiangrong Z,Wenji Z, Yang L, Lingyu J, Sanming L. Development and evaluation of new sustained-release floating microspheres. Int J Pharm.2008; 358: 82-90.
14. Garg S, Gupta GD. Progress in controlled gastro retentive delivery systems. Trop. J Pharm Res. 2008; 7(3): 1055-66.
Published
Abstract Display: 563 
PDF Downloads: 552 
