DEVELOPMENT AND OPTIMIZATION OF QUINAPRIL FAST DISSOLVING ORAL FILMS
Abstract
In current investigation an attempt has been made to formulate and evaluate Quinapril mouth dissolving films using HPMC 50cps, E5, E15 and in combination of Pullulan by Solvent evaporation method. Sodium starch glycolate acts as a super disintegrating agent and it is shown that as the concentration of the super disintegrates increases the disintegration time decreases. The films were evaluated for weight variation, surface pH, folding endurance, drug content, dissolving time, disintegration time, and in-vitro dissolution studies. Based on the evaluation parameters F17 was to be optimized formulation. The optimized film (F17) showed the more drug release i.e 99.40 ± 5.30% within 7 min, lowest in vitro disintegration time 10 sec. FTIR studies proved no drug polymer interaction takes place. These results revealed that fast dissolving films of Quinapril could be formulated for quick onset of action which is required in the efficient management of hypertension.
Keywords:
Quinapril, Mouth dissolving films, HPMC, Pullulan, Hypertension.DOI
https://doi.org/10.25004/IJPSDR.2018.100419References
2. Dinesh kumar V, Sharma I, Sharma V. A comprehensive review on fast dissolving tablet technology. Journal of Applied Pharmaceutical Science. 2011; 01(05): 50-58.
3. Fini A, Bergamante V, Ceschel GC, Ronchi C, de Moraes CA. Fast dispersible slow releasing ibuprofen tablets. Eur J Pharm Biopharm. 2008; 69(1): 335–341.
4. Arya A, Chandra A, Sharma V, Pathak K. Fast Dissolving Oral Films: An Innovative drug delivery System and Dosage Form. International Journal of ChemTech Research. 2010; 2(1): 576-583.
5. Marshall K. The Theory and Practice of Industrial Pharmacy: 3rd edition Varghese Publishing House, Mumbai, 1987, pp. 66-69.
6. Rubia Yasmeen B, Firoz S, Chandra Mouli Y, Vikram A, Mahitha B, Aruna U. Preparation And Evaluation Of Oral Fast Dissolving Films Of Citalopram Hydrobromide. International Journal of Biopharmaceutics. 2012; 3(2): 103-106.
7. Mali AD, Bathe RS. A review on gastroretentive floating tablets of Quinapril HCl. International Journal of Advances in Pharmaceutics. 2014; 3(2):28–31.
8. Senthilkumar K, Vijaya C. Formulation Development of Mouth Dissolving Film of Etoricoxib for Pain Management. Advances in Pharmaceutics. 2015; 11.
9. Yellanki SK, Jagtap S, Masareddy R. Disso film a novel approach for delivery of phenobarbital design and characterization. Journal of Young Pharmacists. 2011; 3: 181–188.
10. Mahendran S, Sekar M, Somasundaram, Jeevanandham Raj Kumar T Muthukumaran M. Design and controlled drug release studies on benazepril microspheres. Journal of Chemical and Pharmaceutical Sciences. 2010; 3: 31-34.
11. Bhyan B, Jangra S, Kaur M, Singh. Orally fast dissolving films innovations in formulation and technology. Int J Pharm Sci Rev Res. 2011; 9:50-56.
12. Nafee NA, Boraie MA, Ismail FA, Mortad LM. Design and characterization of mucoadhesive buccal patches containing cetyl pyridinium chloride. Acta Pharm 2003; 53:199-212.
13. Peh KK, Wong FC. Polymeric films as vehicle for buccal Delivery Swelling, mechanical and bioadhesive properties. J Pharm Sci. 1999; 2:53-61.
14. Agarwal GP, Seth AK, Saini TR. Evaluation of free films. Ind Drugs. 1985; 23:45-7.
15. Deepthi A, Venkateswara RB, Navaneetha K. Formulation and evaluation of fast dissolving oral films of zolmitriptan. AJADD. 2014; 2:153-163.
16. Mishra, R, Amin, A. Formulation Development of Taste-Masked Rapidly Dissolving Films of Cetirizine Hydrochloride. Pharma. Techn. 2009; 48-56.
17. Tanwar YS, Chauhan CS Sharma A. Development and evaluation of carvedilol transdermal patches. Acta Pharm. 2007; 57:151-59.
18. Dinge A, Nagarsenker M. Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity. AAPS Pharm Sci Tech. 2012; 9(2):349-56.
Published
Abstract Display: 490 
PDF Downloads: 592 
