FORMULATION AND EVALUATION OF SOLID DISPERSION INCORPORATED FAST DISINTEGRATING TABLETS OF TENOXICAM USING DESIGN OF EXPERIMENT
Abstract
The aim of the present work is to develop fast dissolving tablets from the solid dispersion of Tenoxicam for enhancement of solubility. The solid dispersions of Tenoxicam were prepared with Kollidon CL, PVP K30 and Poloxamer 127, in 1:1:1, 1:2:1 and 1:3:1 by using solvent evaporation method. The prepared solid dispersions were analyzed for all the physical parameters, drug: carrier interactions like FTIR, SEM, XRD. Solid dispersions showed a better dissolution compared to the pure drugs and among all the other formulations SD9 shows high percentage drug release i.e. 99.11 ± 5.17% for 90 min and selected as an optimized formulation for the preparation of fast disintegrating tablets of Tenoxicam. Gellan Gum, Fenugreek Seed Mucilage and L-HPC (low, middle and high concentrations) used in the preparation of fast disintegrating tablets prepared by direct compression method using 33 Response surface method. The post compression parameters of all the prepared tablets were within the limits. TF13 was selected as optimized formulation based on its highest disintegration time 36 sec and drug release 99.68 ± 1.52% for 10 min. Drug-excipients characterization also revealed that there is no interaction. Hence it concluded that solid dispersions incorporated fast disintegrating tablets is very useful approach for immediate release of Tenoxicam in the efficient management of inflammation and pain.
Keywords:
Tenoxicam, NSAID’s, Solid dispersion, Fast disintegrating tablets, Gellan gumDOI
https://doi.org/10.25004/IJPSDR.2019.110106References
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27. Chauhan K, Parashar B, Chandel A, Thakur V. Formulation and evaluation of Fast Dissolving Tablets of Telmisartan. International Journal of Pharmaceutical Sciences and Research. 2013 Apr 1;4(4):1514.
2. Das PS, Verma S, Saha P. Fast dissolving tablet using solid dispersion technique: a review. Int J Curr Pharm Res. 2017; 9(6):1-4.
3. Rramaswamy R, Mani G, Ranganathan H, Hyun TJ. Preparation of immediate release tablets of Repaglinide by a solubility enhancer and hot-melt extrusion method. Int J Res Ayurveda Pharma. 2016; 7(5): 85-90.
4. Arunprasad K, Narayanan N, Rajalakshmi G. Preparation and evaluation of solid dispersion of terbinafine hydrochloride. Int J Pharm Sci Rev Res. 2010;3(1):130-4.
5. Brahmankar DM, Jaiswal SB. Bioavailability and Bioequivalence, Biopharmaceutics and pharmacokinetics A treatise. Edn II, Vallabh prakashan, 2009, p. 349-357.
6. Varalakshmi TS, Ramesh CS, Jyothi I, Jyothi Y, Bharathi G, Babu PC. Formulation and evaluation of solid dispersions of valsartan for dissolution rate enhancement. Journal of Pharmacy Research Vol. 2015 Feb;9(2):139-44.
7. Satpute MM, Tour NS. Formulation and in vitro evaluation of fast dissolving tablets of metoprolol tartrate. Brazilian Journal of Pharmaceutical Sciences 2013; 49(4):783-792.
8. Armando YP, Schramm SG, de Freitas Silva M, Kano EK, Koono EE, Porta V, dos Reis Serra CH. Bioequivalence assay between orally disintegrating and conventional tablet formulations in healthy volunteers. International journal of pharmaceutics. 2009 Jan 21;366(1-2):149-53.
9. Todd PA, Clissold SP. Tenoxicam: an update of its pharmacology and therapeutic efficacy in rheumatic diseases. Drugs 1991; 41(4): 625–646.
10. El-Hennawy MG, Halim SA, Badawy A, Effat MA. Preparation, Characterization and Evaluation of Tenoxicam Gels and Microemulsion Gels for Topical Drug Delivery. Inventi Rapid: Pharm Tech. 2013; 4: 257-267.
11. Nilsen OG. Clinical Pharmacokinetics of Tenoxicam. Clin Pharmacokinet. 1994; 26(1):16-43.
12. Higuchi T, Connoras K. Phase-solubility techniques. Adv Anal Chem Instrum. 1965; 4:117-212.
13. Lakshmi K, Pranavkumar M, Kaza R. Dissolution enhancement of telmisartan by surface solid dispersion technology. International Journal of Innovative Pharmaceutical Research 2012; 3(4): 247-251.
14. Patel A, Prajapati P, Boghra R, Shah D. Solubility enhancement of poorly aqueous soluble Furosemide using PEG-4000 by solid dispersion. Asian Journal of Pharmaceutical Sciences and Clinical Research. 2011; 1(2): 1-9.
15. Mandal D, Ojha PK, Nandy BC, Ghosh LK. Effect of carriers on solid dispersions of simvastatin (Sim): physico-chemical characterizations and dissolution studies. Der Pharm Lett. 2010;2(4):47-56.
16. Patil S, Lalani R, Bhatt P, Vhora I, Patel V, Patel H, Misra A. Hydroxyethyl substituted linear polyethylenimine for safe and efficient delivery of siRNA therapeutics. RSC Advances. 2018;8(62):35461-73.
17. Bhatt P, Lalani R, Vhora I, Patil S, Amrutiya J, Misra A, Mashru R. Liposomes encapsulating native and cyclodextrin enclosed paclitaxel: Enhanced loading efficiency and its pharmacokinetic evaluation. International journal of pharmaceutics. 2018 Jan 30;536(1):95-107.
18. Bhatt P, Khatri N, Kumar M, Baradia D, Misra A. Microbeads mediated oral plasmid DNA delivery using polymethacrylate vectors: an effectual groundwork for colorectal cancer. Drug delivery 2015;22(6):849-61.
19. Patel J, Amrutiya J, Bhatt P, Javia A, Jain M, Misra A. Targeted delivery of monoclonal antibody conjugated docetaxel loaded PLGA nanoparticles into EGFR overexpressed lung tumour cells. Journal of microencapsulation. 2018 Feb 17;35(2):204-17.
20. Mishra R, Amin A. Quick API Delivery. Pharm Tech Eur. 2013; 19(10): 35-39.
21. Montgomery DC. Design and Analysis of Experiments: Response surface method and designs. John Wiley and Sons, Inc. New Jersey, 2015, pp. 210-256.
22. Ranga S, Jaimini M, Sharma SK, Chauhan BS, Kumar A. A review on Design of Experiments (DOE). Int. J. Pharm. Chem. Sci. 2014;3(1):216-4.
23. Ali S, Quadir A. High molecular weight povidone polymer-based films for fast dissolving drug delivery applications. Drug Del Technol. 2017; 7(6); 36–43.
24. Hariharn M, Bogue A. Orally dissolving film strips (ODFS): The final evolution of orally dissolving dosage forms. Drug Deliv Technol. 2009;9:24–9.
25. Corniellio C. Quick dissolving strips: From concept to commercialization. Drug Deliv Technol. 2006;6:68–71.
26. Kulkarni AS, Deokule HA, Mane MS, Ghadge DM. Exploration of different polymers for use in the formulation of oral fast dissolving strips. J Curr Pharm Res. 2010;2(1):33-5.
27. Chauhan K, Parashar B, Chandel A, Thakur V. Formulation and evaluation of Fast Dissolving Tablets of Telmisartan. International Journal of Pharmaceutical Sciences and Research. 2013 Apr 1;4(4):1514.
Published
20-01-2019
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“FORMULATION AND EVALUATION OF SOLID DISPERSION INCORPORATED FAST DISINTEGRATING TABLETS OF TENOXICAM USING DESIGN OF EXPERIMENT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 11, no. 1, Jan. 2019, pp. 35-44, https://doi.org/10.25004/IJPSDR.2019.110106.
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How to Cite
“FORMULATION AND EVALUATION OF SOLID DISPERSION INCORPORATED FAST DISINTEGRATING TABLETS OF TENOXICAM USING DESIGN OF EXPERIMENT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 11, no. 1, Jan. 2019, pp. 35-44, https://doi.org/10.25004/IJPSDR.2019.110106.
