DESIGNING AND CHARACTERIZATION OF DRUG FREE PATCHES FOR TRANSDERMAL APPLICATION
Abstract
The present investigation was taken up to prepare and evaluate drug free polymeric patches using different polymers and to study the effect of different plasticizers on physicochemical properties of the patches to explore their feasibility for transdermal application. Polyethylene glycol (PEG 400), Dibutylphthalate (DBP) and Propylene glycol (PG) were used as plasticizers at a concentration of 40 % w/w of dry polymer weight. Drug free polymeric patches were prepared by the casting method on mercury surface and evaluated for weight variation, thickness, flatness, tensile strength, folding endurance, surface pH, hardness, swellability, water vapour transmission rate and skin irritation studies. The mercury substrate method was found to give thin uniform patches.
The weight and thickness of the patches was found to be uniform. Tensile strength and folding endurance of the patches prepared with DBP as plasticizer was high compared to patches plasticized with PG and PEG. All the formulations show 100 % flatness. HPMC K4M: PVP patches plasticized with PEG 400 showed higher swellability and water vapour transmission rates. The patches were found to be free of any skin irritation. Based on the above observations, it can be reasonably concluded that plasticizers have a significant influence on the mechanical properties of the transdermal patches.
Keywords:
Transdermal, PEG400, Dibutylphthalate, Propylene glycol, Eudragit, Cellulose acetateDOI
https://doi.org/10.25004/IJPSDR.2010.020106References
2. Takmaz EA, Inal O, Baykara T. Studies on transdermal delivery enhancement of Zidovudine. AAPS Pharm Sci Tech. 2009; 10(1): 89-97.
3. Vasilev AE, Krasnyuk I, Ravikumar S, Tockmakhchi VN. Drug synthesis methods and manufacturing technology, Transdermal therapeutic systems for controlled drug release (A Review). Pharmaceutical Chemistry Journal. 2001; 35(11): 613-626.
4. Guo JH, Effects of plasticizers on water permeation and mechanical properties of cellulose acetate: Antiplasticization in slightly plasticized polymer film. 1993; 19(13): 1541-1555.
5. Ramarao P, Diwan PV. Permeability of cellulose acetate free films for transdermal use: Influence of plasticizers. Pharmaceutica Acta Helvetiae. 1997; 72: 47-51.
6. Entwistle CA, Rowe RE. Plasticization of cellulose ethers used in film coating of tablets. J Pharm Pharmacol. 1979; 31: 269-272.
7. Khanna R, Agarwal SP, Ahuja A. Preparation and Evaluation of Mucoadhesive buccal films of Clotrimazole for oral candida infections. Indian J Pharm Sci. 1997; 59(6): 299-305.
8. Amnuaikit C, Ikeuchi I, Ogawara K, Higaki K, Kimura T, Skin permeation of Propranolol from polymeric film containing terpene enhancers for transdermal use. Int J Pharm. 2005; 289: 167-178.
9. Chandak AR, Verma PRP. Development and evaluation of HPMC based matrices for transdermal patches of Tramadol. Clinical Research and Regulatory Affairs. 2008; 25(1):13–30.
10. Ubaidulla U, Reddy MV, Ruckmani K, Ahmad FJ, Khar RK. Transdermal therapeutic system of Carvedilol: Effect of hydrophilic and hydrophobic matrix on in vitro and in vivo characteristics. AAPS Pharm Sci Tech. 2007; 8(1): E1-E8.
11. Samanta MK, Dube R, Suresh B. Transdermal drug delivery system of Haloperidol to overcome self induced extrapyramidal syndrome. Drug Dev Ind Pharm. 2003; 29(4): 405-415.
12. Ahmed MG, Charyulu RN, Harish NM, Prabhu P. Formulation and in-vitro evaluation of chitosan films containing Tetracycline for the treatment of periodontitis. Asian journal of Pharmaceutics. 2009; 113-119.
13. Saini TR, Seth AK, Agrawal GP. Evaluation of free films. Indian drugs. 1985; 23(1): 45-47.
14. Banweer J, Pandey S, Pathak, AK. Formulation, Optimization and Evaluation of Matrix type Transdermal system of Lisinopril dihydrate using permeation enhancers. Journal of Pharmacy Research. 2008; 1(1): 16-22.
15. Mundada AS, Avari JG. Damar batu as a novel matrix former for the transdermal drug delivery: in vitro evaluation. Drug Dev Ind Pharm. 2009; 35(9): 1147-1154.
16. Patel NA, Patel NJ, Patel RP. Design and Evaluation of Transdermal Drug Delivery System for Curcumin as an Anti-Inflammatory Drug. Drug Dev Ind Pharm. 2009; 35:234–242.l
17. Peh KK, Wong CF. Polymeric films as vehicle for buccal delivery: Swelling, mechanical and bioadhesive properties. J Pharm. Pharm Sci. 1999; 2(2): 53-61.
18. Bottenberg P, Cleymact R, Muynck CD, Remon JP, Coomans D, Michotte Y Development and testing of bioadhesive fluoride containing slow release tablets for oral use. J Pharm Pharmacol. 1991; 43: 457-464.
19. Murthy SN, Hiremath SSR. Preformulation studies of transdermal films of hydroxypropylmethylcellulose and sodiumcarboxymethylcellulose. Int J Pharm Excip. 2002; 34-38.
20. Chowdary KPR, Babu CS. A comparative evaluation of the permeability and drug release kinetics of polymer films and microspheres. Int J Pharm Excip. 2005; 99-103.
21. Bonina FP, Carellii V, Cols GD, Montenegro L, Nannipieri E. Vehicle effects on in vitro skin permeation and stratum corneum affinity for model drugs caffeine and testosterone. Int J Pharm. 1993; 100: 41-47.
22. Draize JH, Woodward G, Calvery HO. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther. 1944; 82: 377-390.
Published
Abstract Display: 742 
PDF Downloads: 754 
