ATOMIC ABSORPTION SPECTROMETRIC METHOD FOR ESTIMATION OF DICLOFENAC SODIUM AND MEFENAMIC ACID IN PHARMACEUTICAL FORMULATIONS
Abstract
Diclofenac sodium and Mefenamic acid have been quantified in tablet dosage form by atomic absorption spectrometry (AAS). These methods are based on formation of the metal complexes of Diclofenac sodium and Mefenamic acid with cupric chloride and cobaltous chloride. The first method is based on reaction of both the drugs with cupric chloride to give light blue colored metal complexes, which are then extracted with dichloromethane and digested with 0.1 M nitric acid. Both the drugs are indirectly estimated via determination of copper content in the formed complexes by AAS. The second method is based on the formation of pink colored complexes of both the drugs with cobaltous chloride. These metal complexes are extracted with dichloromethane and estimated via determination of cobalt content in the formed complexes after digestion with 0.1 M nitric acid by AAS.
Keywords:
chloride, Cobaltous chloride, Atomic absorption spectrometer, Mefenamic acid and Diclofenac sodiumDOI
https://doi.org/10.25004/IJPSDR.2010.020109References
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14. El-Sherif ZA, Walash MI, El-Tarras MF, Osman AO, Colorimetric determination of two nonsteroidal anti-inflammatory drugs using p-dimethylamino cinnamaldehyde. Analytical Letters. 1997; 30(10): 1881-1896.
15. Arancibia JA, Boldrini MA, Escandar GM, Spectrofluorimetric determination of diclofenac in the presence of cyclodextrin. Talanta. 2000; 52(2): 261–268.
16. Ioannou PC, Rusakova NV, Andrikopoulou DA, Glynou KM, Tzompanaki GM. Spectrofluorimetric determination of anthranilic acid derivatives based on terbium-sensitized fluorescence. Analyst (Cambridge, U. K.). 1998; 123(12): 2839-2843.
17. Macia A, Borrull F, Aguilar C, Calull M. Improving sensitivity by large-volume sample stacking using the electroosmotic flow pump to analyse some nonsteroidal anti-inflammatory drugs by capillary electrophoresis in water samples. Electrophoresis. 2003; 24(16): 2779-2787.
18. Wei W, Ju HX. Affinity capillary electrophoresis studies on the influence of alcohols on the interaction of β-cyclodextrin with non-steroidal anti-inflammatory drugs. Chromatographia. 2003; 57(7-8): 449-453.
19. Sioufi A, Pommier F, Godbillon J. Determination of diclofenac in plasma and urine by capillary gas chromatography – mass spectrometry with possible simultaneous determination of deuterium-labelled diclofenac. J.Liq. Chromatoger. 1994; 17(5): 1065-1088.
20. Reddersen K, Heberer T. Multi-compound methods for the detection of pharmaceutical residues in various waters applying solid phase extraction (SPE) and gas chromatography with mass spectrometric (GC-MS) detection. Journal of Separation Science. 2003; 26(15-16): 1443-1450.
2. Hardman G, Limbird Lee E. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. Edn 10, Mc Graw-Hill, Medical Publishing Division, New York, 2001, pp. 709-711.
3. Agatonovic-Kustrin, S, Zivanovic L, Zecevic M, Radulovic D. Spectrophotometric study of diclofenac-iron (III) complex. Analytical letters. 1997; 30(12): 2235-2249.
4. Botello JC, Perex-Caballero G. Spectrophotometric determination of declofenac sodium with methylene blue. Indian Drugs. 1995; 32 (4): 194-196.
5. Dinc E, Yucesoy C, Onur F. Simultaneous Spectrophotometric determination of mefenamic acid and paracetamol in a pharmaceutical preparation using ratio spectra derivative spectrophotometry and chemometric methods. Journal of Pharmaceutical and Biomedical Analysis, 2002; 28 (6): 1091-1100.
6. Das S, Sharma SC, Talwar SK, Sethi PD. Simultaneous spectrophotometric determination of mefenamic acid and paracetamol in pharmaceutical preparations. Analyst (London). 1989; 114 (1): 101-103.
7. Malliou ET, Markopoulou CK, Koundourellis JE. Simultaneous determination of clobutinol together with some anti-inflammatory drugs in urine by HPLC. Journal of Liquid Chromatography & Related Technologies. 2004; 27 (10): 1565-1577.
8. Sun Y, Takaba K, Kido, H, Nakashima, MN, Nakashima, K. Simultaneous determination of arylpropionic acid non-steroidal anti-inflammatory drugs in pharmaceutical formulations and human plasma by HPLC with UV detection. Journal of Pharmaceutical and Biomedical Analysis. 2003; 30 (5): 1611-1619.
9. Rouini MR, Asadipour A, Ardakani YH, Aghdasi F. Liquid chromatography method for determination of mefenamic acid in human serum. Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences. 2004; 800(1-2): 189-192.
10. Cerretani D, Micheli L, Fiaschi AI, Giorgi G. High-performance liquid chromatography of flufenamic acid and mefenamic acid in rat plasma. Journal of Chromatography, B: Biomedical Applications. 1996; 678(2): 365-368.
11. Dorado P, Berecz R, Caceres MC, Llerena A. Sensitive HPTLC method for monitoring dissolution profiles of diclofenac from different tablets containing combined diclofenac and acetaminophen. Journal of Chromatography, B.Analytical Technologies in the Biomedical and Life Sciences. 2003; 89(2): 437-442.
12. Argekar AP, Sawant JG. Simultaneous determination of paracetamol and mefenamic acid in tablets by HPTLC. Journal Planar Chromatography-Modern TLC. 1999; 12(5): 361-364.
13. Mathur SC, Kumar Y, Prasad Rao PBN, Rathore ACS, Gupta YKS, A simple colorimetric estimation of diclofenac sodium in dosage forms. Indian Drugs. 1994; 31(9): 447-448.
14. El-Sherif ZA, Walash MI, El-Tarras MF, Osman AO, Colorimetric determination of two nonsteroidal anti-inflammatory drugs using p-dimethylamino cinnamaldehyde. Analytical Letters. 1997; 30(10): 1881-1896.
15. Arancibia JA, Boldrini MA, Escandar GM, Spectrofluorimetric determination of diclofenac in the presence of cyclodextrin. Talanta. 2000; 52(2): 261–268.
16. Ioannou PC, Rusakova NV, Andrikopoulou DA, Glynou KM, Tzompanaki GM. Spectrofluorimetric determination of anthranilic acid derivatives based on terbium-sensitized fluorescence. Analyst (Cambridge, U. K.). 1998; 123(12): 2839-2843.
17. Macia A, Borrull F, Aguilar C, Calull M. Improving sensitivity by large-volume sample stacking using the electroosmotic flow pump to analyse some nonsteroidal anti-inflammatory drugs by capillary electrophoresis in water samples. Electrophoresis. 2003; 24(16): 2779-2787.
18. Wei W, Ju HX. Affinity capillary electrophoresis studies on the influence of alcohols on the interaction of β-cyclodextrin with non-steroidal anti-inflammatory drugs. Chromatographia. 2003; 57(7-8): 449-453.
19. Sioufi A, Pommier F, Godbillon J. Determination of diclofenac in plasma and urine by capillary gas chromatography – mass spectrometry with possible simultaneous determination of deuterium-labelled diclofenac. J.Liq. Chromatoger. 1994; 17(5): 1065-1088.
20. Reddersen K, Heberer T. Multi-compound methods for the detection of pharmaceutical residues in various waters applying solid phase extraction (SPE) and gas chromatography with mass spectrometric (GC-MS) detection. Journal of Separation Science. 2003; 26(15-16): 1443-1450.
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01-01-2010
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“ATOMIC ABSORPTION SPECTROMETRIC METHOD FOR ESTIMATION OF DICLOFENAC SODIUM AND MEFENAMIC ACID IN PHARMACEUTICAL FORMULATIONS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 1, Jan. 2010, pp. 45-47, https://doi.org/10.25004/IJPSDR.2010.020109.
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How to Cite
“ATOMIC ABSORPTION SPECTROMETRIC METHOD FOR ESTIMATION OF DICLOFENAC SODIUM AND MEFENAMIC ACID IN PHARMACEUTICAL FORMULATIONS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 1, Jan. 2010, pp. 45-47, https://doi.org/10.25004/IJPSDR.2010.020109.
