FORMULATION AND CHARACTERIZATION OF FAST-DISSOLVING TABLETS OF RALOXIFENE HYDROCHLORIDE
Abstract
Fast Dissolving Tablet (FDT) of Raloxifene was prepared by direct-compression method by incorporating super disintegrants like crosscarmellose sodium and sodium starch glycolate. The study was performed by incorporating the super disintegrants in 2 % and 4 % concentration for each and 2 % - 2 % in combination of both super disintegrants. Five formulations having super disintegrants at different concentration levels were prepared to assess their efficiency. Different types of evaluation parameters for tablets were performed. Tablets containing super disintegrants in combination showed excellent in vitro dispersion time and drug release as compared to other formulations.
Keywords:
Fast dissolving tablets, Direct compression, RaloxifeneDOI
https://doi.org/10.25004/IJPSDR.2010.020112References
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4. Sharma S, Gupta GD. Formulation and characterization of fast dissolving tablets of Promethazine theoclate. Asian Journal of Pharmaceutics 2008; 70-72.
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8. Setty MC, Prasad DVK, Gupta RM, Sa B. Development of fast dispersible Aceclofenac tablets: Effect of functionality of superdisintegrants. Indian J Pharm Sci 2008; 70(2): 180-185.
9. Kundu S, Sahoo PK. Recent trends in the developments of orally disintegrating technology. Pharma Times 2008; 40(4): 11-15.
10. Chakraborthy S, Khandai M, Singh SP. Patra N. Comparitive study on effect of natural and synthetic superdisintegrant in the formulation of fast dissolving tablets; International Journal of Green Pharmacy 2008; 22-25.
11. Zade PS, Kwatikwar PS, Sakarkar DM, Formulation evaluation and optimization of fast dissolving tablets containing tizanidine hydrochloride. International Journal of Pharm Tech Research 2009; 1(1): 34-42.
2. Budavari S. Merck index, 13th ed. Merck and Co Inc. Whiteshouse station, NJ, 2001, pp. 1452.
3. Brezenoff, Giuliano, Howland, Radice, McArdle, In; Lipincott’s illustrated Reviews: Pharmacology, Lipincott Williams and Wilkin, 2nd ed, 1997, pp. 454.
4. Sharma S, Gupta GD. Formulation and characterization of fast dissolving tablets of Promethazine theoclate. Asian Journal of Pharmaceutics 2008; 70-72.
5. Leon Lachman, Lieberman HA and Kanig JL. The theory and practice of Industrial pharmacy, 3rd ed. Varghese publishing house. 1987, pp. 67.
6. Swamy PV, Areefulla SH, Shirsand SB, Gandra S, Prashanth B. Orodispersible tablets of Meloxicam using disintegrants blends for improved efficacy. Indian J Pharm Sci 2007; 69(6): 836-840.
7. Jacob S, Shirwaikar AA, Joseph A, Sriniwasan KK. Novel co-processed excipients of mannitol and microcrystalline cellulose for preparing fast dissolving tablets of glipizide. Indian J Pharm Sci 2007; 69(5): 633-639.
8. Setty MC, Prasad DVK, Gupta RM, Sa B. Development of fast dispersible Aceclofenac tablets: Effect of functionality of superdisintegrants. Indian J Pharm Sci 2008; 70(2): 180-185.
9. Kundu S, Sahoo PK. Recent trends in the developments of orally disintegrating technology. Pharma Times 2008; 40(4): 11-15.
10. Chakraborthy S, Khandai M, Singh SP. Patra N. Comparitive study on effect of natural and synthetic superdisintegrant in the formulation of fast dissolving tablets; International Journal of Green Pharmacy 2008; 22-25.
11. Zade PS, Kwatikwar PS, Sakarkar DM, Formulation evaluation and optimization of fast dissolving tablets containing tizanidine hydrochloride. International Journal of Pharm Tech Research 2009; 1(1): 34-42.
Published
01-01-2010
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“FORMULATION AND CHARACTERIZATION OF FAST-DISSOLVING TABLETS OF RALOXIFENE HYDROCHLORIDE”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 1, Jan. 2010, pp. 55-57, https://doi.org/10.25004/IJPSDR.2010.020112.
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How to Cite
“FORMULATION AND CHARACTERIZATION OF FAST-DISSOLVING TABLETS OF RALOXIFENE HYDROCHLORIDE”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 1, Jan. 2010, pp. 55-57, https://doi.org/10.25004/IJPSDR.2010.020112.
