TIME DEPENDENT ANTIOXIDANT ACTIVITY OF FRESH JUICE OF LEAVES OF CORIANDRUM SATIVUM
Abstract
The antioxidant activities of fresh juice of Coriandrum sativum was evaluated by various methods in vivo. Scavenging effects on the hydroxyl and super oxide radicals, level of glutathione and protection against reactive oxygen species induced lipid were evaluated. The fresh juice exhibited high antioxidant activities, evidenced by its ability to scavenge hydroxyl- and superoxide-radicals, high reducing power, and protection against biological macromolecular oxidative damage and by increasing the level of glutathione. Presence of flavonoids confirms its antioxidant activity. In conclusion, these results demonstrate potential antioxidant activity of fresh juice of Coriandrum sativum.
Keywords:
Coriandrum sativum, antioxidant, flavonoids, lipid peroxidation, glutathioneDOI
https://doi.org/10.25004/IJPSDR.2010.020114References
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9. Karlsen J, Chingova B, Zwetkov R, Baerheim-Svendsren A. Studies on the essential oil of the fruits of Coriandrum sativum L. by means of gas liquid chromatography XI. Studies on terpens and related compounds. Pharmaceut Weekbl 1971; 106: 296-300.
10. Berton TR, Conti CJ, Mitchell DL, Aldaz CM, Lubet RA, Fisher SM. The effect of vitamin E acetate on ultraviolet-induced mouse skin carcinogenesis. Mol. Carcinogen 1998; 23:175-184.
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12. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 1978; 186: 189-95.
13. Buetler E, Duron O, Kelly BM. Improved method for determination of blood glutathione. J Lab Clin Med 1963; 61: 882-8.
14. Sharma MK, Buettner GR. Interaction of Vit C and Vit E during free radical stress in plasma: an ESR study. Biochemistry 1993; 32: 10692.
15. Jhonston CS, Luo B, Monte WC. Vitamin C elevate red blood cell glutathione in healthy adults. Am J Clin Nutr 1993; 586: 103.
16. Naito Y, Yosikawa T, Matsuyama K, Yagi N, Aral M, Nakamura S, Yoshida N, Konda M. Effect of oxygen radical scavengers on the quality of gastric ulcer healing in rats. J Clin Gastroenterol 1995; 21: S82.
17. Easterbauer H. in Free radical lipid peroxidation and cancer (Slater TF, McBrain D ed. Academic Press, New York, 1982, pp.101-128.
18. Housteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol. 1983; 32: 1141-1148.
19. Sumanth M, Rana AC. In vivo antioxidant activity of ydroalcoholic extract of Taraxacum officinale roots in rats. Indian J Pharmacol 2006; 38: 54-5.
20. Meilhac O, Zhou M, Santanam N, Parthasarthy S. Lipid peroxides induce expression of catalase in cultured vascular cells. J Lipid Res. 2000; 41: 1205.
21. Sabu MC, Kultan R. Anti-diabetic activity of Aegle marmelos and its relationship with its anti-oxidant properties. Indian J Physiol Pharmacol 2004; 48(1): 81-88.
22. Kosower NS, Kosower EM. The glutathione status of cells. Intl Rev Cytology 1978; 54: 109-156.
23. Meister A. Glutathione metabolism and transport. In: Nygaard O F, Simic MG, ed. Radioprotectors and Anticarcinogens. New York, NY: Academic Press; 1976
2. Bland JS. Oxidants and antioxidants in clinical medicine: Past, present and future potential. Journal of Nutritional and Environment Medicine 1995; 5: 255–280.
3. Halliwell B, Gutteridge JMC. Role of free radicals and catalytic metal ions in human disease: An overview. Methods in Enzymology 1990; 186: 1–85.
4. Floyd RA. Antioxidants, oxidative stress, and degenerative neurological disorders. Proceedings of the Society for Experimental Biology and Medicine 1999; 222: 236–245.
5. Shetgiri PP, D′Mello PM. Antioxidant activity of flavanoids-A comparitive study. Indian Drugs 2003; 40: 567-9.
6. Gopinathan N, Srinivasan KK, Mathew JE. Free radical scavenging properties of ethanol extract of Saccharum spontaneum. Indian Drugs 2004; 41: 633-5.
7. Araceli S, Camen RM, Guillermo RS, Salvador M, Rosa MG. Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside. Eur J Pharmacol 2003; 461: 53-61.
8. Rajnaryana K, Sripalreddy M, Chalavadi MR, Krishna DR. Bioflavonoids classification, pharmacological, Biochemical effects and therapeutic potential. Indian J Pharmacol 2001; 33:2-16.
9. Karlsen J, Chingova B, Zwetkov R, Baerheim-Svendsren A. Studies on the essential oil of the fruits of Coriandrum sativum L. by means of gas liquid chromatography XI. Studies on terpens and related compounds. Pharmaceut Weekbl 1971; 106: 296-300.
10. Berton TR, Conti CJ, Mitchell DL, Aldaz CM, Lubet RA, Fisher SM. The effect of vitamin E acetate on ultraviolet-induced mouse skin carcinogenesis. Mol. Carcinogen 1998; 23:175-184.
11. Aebi H. Catalase in vitro. In: Packer, L. (Ed.), Methods in Enzymology, vol. 105, Academic Press, San Diego, 1984, pp. 121-126.
12. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 1978; 186: 189-95.
13. Buetler E, Duron O, Kelly BM. Improved method for determination of blood glutathione. J Lab Clin Med 1963; 61: 882-8.
14. Sharma MK, Buettner GR. Interaction of Vit C and Vit E during free radical stress in plasma: an ESR study. Biochemistry 1993; 32: 10692.
15. Jhonston CS, Luo B, Monte WC. Vitamin C elevate red blood cell glutathione in healthy adults. Am J Clin Nutr 1993; 586: 103.
16. Naito Y, Yosikawa T, Matsuyama K, Yagi N, Aral M, Nakamura S, Yoshida N, Konda M. Effect of oxygen radical scavengers on the quality of gastric ulcer healing in rats. J Clin Gastroenterol 1995; 21: S82.
17. Easterbauer H. in Free radical lipid peroxidation and cancer (Slater TF, McBrain D ed. Academic Press, New York, 1982, pp.101-128.
18. Housteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol. 1983; 32: 1141-1148.
19. Sumanth M, Rana AC. In vivo antioxidant activity of ydroalcoholic extract of Taraxacum officinale roots in rats. Indian J Pharmacol 2006; 38: 54-5.
20. Meilhac O, Zhou M, Santanam N, Parthasarthy S. Lipid peroxides induce expression of catalase in cultured vascular cells. J Lipid Res. 2000; 41: 1205.
21. Sabu MC, Kultan R. Anti-diabetic activity of Aegle marmelos and its relationship with its anti-oxidant properties. Indian J Physiol Pharmacol 2004; 48(1): 81-88.
22. Kosower NS, Kosower EM. The glutathione status of cells. Intl Rev Cytology 1978; 54: 109-156.
23. Meister A. Glutathione metabolism and transport. In: Nygaard O F, Simic MG, ed. Radioprotectors and Anticarcinogens. New York, NY: Academic Press; 1976
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01-01-2010
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“TIME DEPENDENT ANTIOXIDANT ACTIVITY OF FRESH JUICE OF LEAVES OF CORIANDRUM SATIVUM”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 1, Jan. 2010, pp. 63-66, https://doi.org/10.25004/IJPSDR.2010.020114.
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Copyright (c) 2010 D. Panjwani, B. Mishra, D. Banji
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
“TIME DEPENDENT ANTIOXIDANT ACTIVITY OF FRESH JUICE OF LEAVES OF CORIANDRUM SATIVUM”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 1, Jan. 2010, pp. 63-66, https://doi.org/10.25004/IJPSDR.2010.020114.
