Analysis of Metformin on Endogenous Antioxidants and Oxidative Stress in Mice Brain Tissue of Alloxan-Induced Diabetes

Authors

  • Harsha Kashyap Department of Bioscience and Biotechnology, Banasthali University, P.O. Banasthali Vidyapith-304 022, Tonk, Rajasthan, India
  • Sarika Gupta Department of Bioscience and Biotechnology, Banasthali University, P.O. Banasthali Vidyapith-304 022, Tonk, Rajasthan, India

Abstract

Diabetes has become a serious threat to mankind, as it is found in all parts of the world. Alloxan induced diabetic mice were treated by metformin to study the impact of oxidative stress and endogenous antioxidants. Due to the establishment of diabetes, the oxidative stress indicators were found to be positively correlated with the elevation in the levels of endogenous antioxidants. Whereas, in metformin-treated diabetic mice, the data revealed the correction of diabetes by lowering of blood glucose level along with body weight. But the levels of endogenous antioxidants were not recorded to increase except GST. It shows that under in vivo system level of oxidative stress increases due to the metformin. The data revealed that metformin treatment of mice, however, manage the glucose level but not effective in controlling oxidative stress.

Keywords:

Alloxan, Oxidative stress, Endogenous antioxidants, blood glucose level, in vivo system, metformin.

DOI

https://doi.org/10.25004/IJPSDR.2019.110519

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Published

25-09-2019
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How to Cite

“Analysis of Metformin on Endogenous Antioxidants and Oxidative Stress in Mice Brain Tissue of Alloxan-Induced Diabetes”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 11, no. 5, Sept. 2019, pp. 272-7, https://doi.org/10.25004/IJPSDR.2019.110519.

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Research Article

How to Cite

“Analysis of Metformin on Endogenous Antioxidants and Oxidative Stress in Mice Brain Tissue of Alloxan-Induced Diabetes”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 11, no. 5, Sept. 2019, pp. 272-7, https://doi.org/10.25004/IJPSDR.2019.110519.

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