DESIGN AND CHARACTERIZATION OF AMOXICILLIN TRIHYDRATE MUCOADHESIVE MICROSPHERES FOR PROLONGED GASTRIC RETENTION
Abstract
Whilst there is keen interest in developing improved drug delivery systems to gastro intestinal tract for treatment of Helicobacter pylori induced peptic and duodenal ulcers, In an effort to augment the anti-Helicobacter pylori effect of Amoxicillin trihydrate mucoadhesive microspheres, which have the ability to reside in the gastrointestinal tract for an extended period, were prepared with ethyl cellulose as a matrix and carbopol 934P as a mucoadhesive polymer. Particle size was determined by optical micrometer and average particle size was found in the range of 500-560 m for all batches. All the batches showed good in vitro mucoadhesive property. Cumulative percent drug release was found to be maximum for FI (91.12 %). Formulation FII found to follow Higuchi matrix with the regression value of 0.9985. Form the all batches FI formulated microspheres showed more mucoadhesive property due to less amount of ethyl cellulose. In conclusion, the prolonged gastrointestinal residence time and controlled release might make contribution to H. Pylori clearance.
Keywords:
Amoxicillin trihydrate, Carbopol 934P, H. pylori, Mucoadhesive microspheresDOI
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Copyright (c) 2010 Shiva Kumar Yellanki, Jeet Singh, Jawad Ali Syed, Rajkamal Bigala, Sharada Goranti, Naveen Kumar Nerella
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