A Comprehensive Review of the Phytochemistry and Pharmacological Profiles of Musa acuminata (Family: Musaceae)
Abstract
Musa acuminata, commonly called the banana plant, is a cornerstone of tropical agriculture and also in traditional medicine, recognized for its extensive phytochemical composition encompassing phenolic compounds, flavonoids, alkaloids, and terpenoids. Each segment of the plant includes the fruit pulp, peel, leaves, and pseudostem—harbors bioactive constituents that manifest a wide spectrum of pharmacological activities, such as anti-inflammatory, antimicrobial, antidiabetic, antioxidant, and cardiovascular effects. This review consolidates traditional knowledge and contemporary research to elucidate the therapeutic potential of M. acuminata in modern medicine. It underscores the imperative for further investigation into the plant’s genetic attributes to fully harness its pharmacological capabilities. By highlighting both the nutritional value and the diverse traditional and prospective therapeutic applications, this review provides a foundational framework for future research endeavors aimed at advancing global health and agriculture through the utilization of M. acuminata.
Keywords:
Musa acuminata, Phytochemistry, Pharmacology, Banana, MusaceaeDOI
https://doi.org/10.25004/IJPSDR.2024.160516References
Ji HF, Li XJ, Zhang HY. Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia? EMBO Rep. 2009 Mar;10(3):194-200. doi: 10.1038/embor.2009.12.
Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. doi: 10.1021/np068054v.
Kamboj VP. Herbal Medicine. Curr. Sci. 2000;78(1):35–39. JSTOR, http://www.jstor.org/stable/24103844. Accessed 21 June 2024.
Pothavorn P, Kitdamrongsont K, Swangpol S, Wongniam S, Atawongsa K, Savasti J, Somana J. Sap phytochemical compositions of some bananas in Thailand. J Agric Food Chem. 2010 Aug 11;58(15):8782-7. doi: 10.1021/jf101220k.
Uma S, Arun K. Understanding the diversity and reproductive biology of banana - for improvement through basic research. Acta Hortic. 2016. 1114: 1–12. https://doi.org/10.17660/ActaHortic.2016.1114.1
Subbaraya U, Lutaladio N, Baudoin WO. Farmers’ knowledge of wild Musa in India. Food and Agriculture Organization of the United Nations, 46, 2006.
Backiyarani S, Uma S, Anuradha C, Chandrasekar A. Application of “omics” in banana improvement (G. R. Rout & K. V. B. T.-O. in H. C. Peter (eds.); Academic Press, 2022, pp. 165–191.
Thingnam SS, Lourembam DS, Tongbram PS, Lokya V, Tiwari S, Khan MK et al. A Perspective Review on Understanding Drought Stress Tolerance in Wild Banana Genetic Resources of Northeast India. Genes, 2023 14(2). doi: https://doi.org/10.3390/genes14020370
Vu TD, Vu DT, Janssens SB, De Langhe E, Le LT, Kallow S, et al. The description, distribution and habitat of wild banana species in northern Viet Nam. Genetic Resources and Crop Evolution. 2023;70(2):479–504. doi: https://doi.org/10.1007/s10722-022-01442-2
Sardos J, Breton C, Perrier X, Van den Houwe I, Carpentier S, Paofa J, Rouard M, Roux N. Hybridization, missing wild ancestors and the domestication of cultivated diploid bananas. Front Plant Sci. 2022 Oct 7;13:969220. doi: 10.3389/fpls.2022.969220.
Muthusamy M, Uma S, Backiyarani S, Saraswathi MS. Expression profiling of microRNAs in banana (Musa spp.) during soil moisture deficit stress. J Hortic Sci Biotech. 2016;89:208–214. doi: https://doi.org/10.1080/14620316.2014.1151307
Chao X, Dai W, Li S, Jiang C, Jiang Z, Zhong G. Identification of circRNA-miRNA-mRNA Regulatory Network and Autophagy Interaction Network in Atrial Fibrillation Based on Bioinformatics Analysis. Int J Gen Med. 2021 Nov 19;14:8527-8540. doi: 10.2147/IJGM.S333752.
Tripathi L, Ntui VO, Tripathi JN. CRISPR/Cas9-based genome editing of banana for disease resistance. Curr Opin Plant Biol. 2020 Aug;56:118-126. DOI: 10.1016/j.pbi.2020.05.003. PMID: 32604025.
Oliveira L, Freire CS, Silvestre AJ, Cordeiro N. Lipophilic extracts from banana fruit residues: a source of valuable phytosterols. J Agric Food Chem. 2008 Oct 22;56(20):9520-4. doi: 10.1021/jf801709t. Epub 2008 Sep 26.
Hardisson A, Rubio C, Baez A, Martin M, Alvarez R, Diaz, E. Mineral composition of the banana (Musa acuminata) from the island of Tenerife. Food Chem. 2001;73(2):153–161. doi: https://doi.org/10.1016/S0308-8146(00)00252-1
Nutritional value of cultivars of Banana (Musa spp.) and its future prospects. J Pharmacogn Phytochem 2018;7(3):2972-2977.
Fatchurohmah W, Meliala A, Sulistyoningsih RC. Effect of banana peel extract on serotonin immunoreactivity and stool consistency in colon of healthy male Wistar rat. AIP Conference Proceedings. 2019, pp.1–8.
Iwasawa H, Yamazaki M. Differences in biological response modifier-like activities according to the strain and maturity of bananas. Food Sci Technol Res. 2009;15(3):275–282. doi: 10.3136/fstr.15.275
Ochola D, Jogo W, Ocimati W, Rietveld A, Tinzaara W. Karamura DA and Karamura EB. Farmers awareness and perceived benefits of agro-ecological intensification practices in banana systems in Uganda. Afr. J. Biotechnol. 2013;12(29):4603–4613. doi: 10.5897/AJB12.2868
Muthee JK, Gakuya DW, Mbaria JM, Kareru PG, Mulei CM, Njonge FK. Ethnobotanical study of anthelmintic and other medicinal plants traditionally used in Loitoktok district of Kenya. J Ethnopharmacol. 2011;Apr26:135(1):15-21. doi: 10.1016/j.jep.2011.02.005.
Chintamunnee V, Mahomoodally MF. Herbal medicine commonly used against non-communicable diseases in the tropical island of Mauritius. J Herb Med. 2012;2(4):113–125. doi: https://doi.org/https://doi.org/10.1016/j.hermed.2012.06.001
Okon JE, Esenowo GJ, Afaha IP, Umoh NS. Haematopoietic properties of ethanolic fruit extract of Musa acuminata on albino rats. Bull Env Pharmacol Life Sci. 2013;2: 22–26.
Ticktin T, Dalle SP. Medicinal plant use in the practice of midwifery in rural Honduras. J Ethnopharmacol. 2005;96(1):233–248. doi: https://doi.org/https://doi.org/10.1016/j.jep.2004.09.015
Houghton PJ, Osibogun IM. Flowering plants used against snakebite. Journal of Ethnopharmacology. 1993;39(1): 1–29. doi:https://doi.org/https://doi.org/10.1016/0378-8741(93)90047-9
De Wet H, Nzama VN, Van Vuuren SF. Medicinal plants used for the treatment of sexually transmitted infections by lay people in northern Maputaland, KwaZulu–Natal Province, South Africa. S Afr J Bot. 2012;78:12–20. doi:https://doi.org/https://doi.org/10.1016/j.sajb.2011.04.002
Kambizi L, Afolayan AJ. An ethnobotanical study of plants used for the treatment of sexually transmitted diseases (njovhera) in Guruve District, Zimbabwe. J Ethnopharmacol. 2001 Sep;77(1):5-9. doi: 10.1016/s0378-8741(01)00251-3.
Ndubani P, Höjer B. Traditional healers and the treatment of sexually transmitted illnesses in rural Zambia. J Ethnopharmacol. 1999 Oct;67(1):15-25. doi: 10.1016/s0378-8741(99)00075-6.
Kamatenesi-Mugisha M, Oryem-Origa H. Medicinal plants used to induce labour during childbirth in western Uganda. J Ethnopharmacol. 2007 Jan 3;109(1):1-9. doi: 10.1016/j.jep.2006.06.011.
Sur Z, Morilla LJG, Sumaya NHN, Rivero HI, Reina M, Madamba SB. Medicinal Plants of the Subanens in Dumingag, Zamboanga del Sur, Philippines. In the conference proceedings, International Conference on Food, Biological and Medical Sciences, Bangkok, Thailand. 2014. doi: https://doi.org/10.15242/iicbe.c0114577
Lamxay V, de Boer HJ, Björk L. Traditions and plant use during pregnancy, childbirth and postpartum recovery by the Kry ethnic group in Lao PDR. J Ethnobiol Ethnomed. 2011 May 10;7:14. doi: 10.1186/1746-4269-7-14.
Uddin S, Sajib NH, Islam MM. Investigation of ethnomedicinal plants of Subarnachar in Noakhali, Bangladesh. Chittagong Univ. J. Biol. Sci. 2013;6(1–2):77–86. doi: https://doi.org/10.3329/cujbs.v6i1-2.17085
Sen S, Chakraborty R, De B, Devanna N. An ethnobotanical survey of medicinal plants used by ethnic people in West and South district of Tripura, India. J For Res. 2011;22(3):417–426. doi:https://doi.org/10.1007/s11676-011-0184-6
Sengupta S, Chowdhury S, BoseDasgupta S, Wright CW, Majumder HK. Cryptolepine-induced cell death of Leishmania donovani promastigotes is augmented by inhibition of autophagy. Mol Biol Int. 2011;187850–187912. doi:10.4061/2011/187850
Pereira A, Maraschin M. Banana (Musa spp) from peel to pulp: ethnopharmacology, source of bioactive compounds and its relevance for human health. J Ethnopharmacol. 2015 Feb 3;160:149-63. doi: 10.1016/j.jep.2014.11.008. Epub 2014 Nov 13.
Vijay N, Shashikant D, Mohini P. Assessment of antidiabetic potential of Musa acuminata peel extract and its fractions in experimental animals and characterisation of its bioactive compounds by HPTLC. Arch Physiol Biochem. 2022 Apr;128(2):360-372. doi: 10.1080/13813455.2019.1683585.
Sethiya NK, Shekh MR, Singh PK. Wild banana [Ensete superbum (Roxb.) Cheesman.]: Ethnomedicinal, phytochemical and pharmacological overview. J Ethnopharmacol. 2019 Apr 6;233:218-233. doi: 10.1016/j.jep.2018.12.048.
Gunavathy N, Padmavathy S, Murugavel SC. Phytochemical Evaluation of Musa Acuminata Bract Using Screening, Ftir and Uv-Vis Spectroscopic Analysis. Int Multidiscip Res J. 2014;393(1): 212–221.
Mathew NS, Negi PS. Traditional uses, phytochemistry and pharmacology of wild banana (Musa acuminata Colla): A review. J Ethnopharmacol. 2017 Jan 20;196:124-140. doi: 10.1016/j.jep.2016.12.009.
Cheung AH, Wong JH, Ng TB. Musa acuminata (Del Monte banana) lectin is a fructose-binding lectin with cytokine-inducing activity. Phytomedicine. 2009 Jun;16(6-7):594-600. doi: 10.1016/j.phymed.2008.12.016.
Ghag SB, Ganapathi, TR. Banana and Plantains: Improvement, Nutrition, and Health. In: Mérillon, JM., Ramawat, K.G. (eds) Bioactive Molecules in Food. Reference Series in Phytochemistry. Springer, 2019, Cham. https://doi.org/10.1007/978-3-319-78030-6_73https://doi.org/https://doi.org/10.1016/j.foodchem.2009.08.012
Mahouachi J, López-Climent MF, Gómez-Cadenas A. Hormonal and hydroxycinnamic acids profiles in banana leaves in response to various periods of water stress. ScientificWorldJournal. 2014;2014:540962. doi: 10.1155/2014/540962.
Aldenderfer, Mark S, Craig, Nathan M, Speakman, Robert Jeff, Popelka-Filcoff, Rachel S. 2008. "Supporting Information." Proceedings of the National Academy of Sciences of the United States of America. 105 (13):1–6.
Vilela C, Santos SA, Villaverde JJ, Oliveira L, Nunes A, Cordeiro N, Freire CS, Silvestre AJ. Lipophilic phytochemicals from banana fruits of several Musa species. Food Chem. 2014 Nov 1;162:247-52. doi: 10.1016/j.foodchem.2014.04.050.
Bennett RN, Shiga TM, Hassimotto NM, Rosa EA, Lajolo FM, Cordenunsi BR. Phenolics and antioxidant properties of fruit pulp and cell wall fractions of postharvest banana (Musa acuminata Juss.) cultivars. J Agric Food Chem. 2010 Jul 14;58(13):7991-8003. doi: 10.1021/jf1008692.
Islam MR, Afrin S, Khan TA, Howlader Z. Nutrient content and antioxidant properties of some popular fruits in Bangladesh. Int. J. Pharm. Sci. 2015;6(4):1407–1414.
González-Montelongo R, Gloria Lobo M, González M. Antioxidant activity in banana peel extracts: Testing extraction conditions and related bioactive compounds. Food Chemistry. 2010;119(3), 1030–1039. doi:https://doi.org/https://doi.org/10.1016/j.foodchem.2009.08.012
Tuárez-García DA, Galván-Gámez H, Erazo Solórzano CY, Edison Zambrano C, Rodríguez-Solana R, Pereira-Caro G et al. Effects of Different Heating Treatments on the Antioxidant Activity and Phenolic Compounds of Ecuadorian Red Dacca Banana. Plants. 2023;12:2780. doi: https://doi.org/10.3390/plants12152780
Binks RH, Greenham JR, Luis JG, Gowen SR. A phytoalexin from roots of Musa acuminata var. pisang sipulu. Phytochemistry. 1997;45(1),47–49. doi:https://doi.org/https://doi.org/10.1016/S0031-9422(96)00796-0
Choudhury SR, Roy S, Sengupta DN. A Ser/Thr protein kinase phosphorylates MA-ACS1 (Musa acuminata 1-aminocyclopropane-1-carboxylic acid synthase 1) during banana fruit ripening. Planta. 2012 Aug;236(2):491-511. doi: 10.1007/s00425-012-1627-9.
Chung T, Phillips AR, Vierstra RD. ATG8 lipidation and ATG8-mediated autophagy in Arabidopsis require ATG12 expressed from the differentially controlled ATG12A AND ATG12B loci. Plant J. 2010 May;62(3):483-93. doi: 10.1111/j.1365-313X.2010.04166.x.
Swanson MD, Winter HC, Goldstein IJ, Markovitz DM. A lectin isolated from bananas is a potent inhibitor of HIV replication. J Biol Chem. 2010 Mar 19;285(12):8646-55. doi: 10.1074/jbc.M109.034926.
Hirai N, Ishida H, Koshimizu KA. phenalenone-type phytoalexin from Musa acuminata. Phytochemistry. 1994;37(2):383–385. doi:https://doi.org/https://doi.org/10.1016/0031-9422(94)85064-X
Meenashree B, Vasanthi VJ, Mary RNI. Evaluation of total phenolic content and antimicrobial activities exhibited by the leaf extracts of Musa acuminata (banana). Int J Curr Microbiol Appl Sci. 2014; 3(5):136–141.
Laraia L, McKenzie G, Spring DR, Venkitaraman AR, Huggins DJ. Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions. Chem Biol. 2015 Jun 18;22(6):689-703. doi: 10.1016/j.chembiol.2015.04.019.
Duggina P, Kalla CM, Varikasuvu SR, Bukke S, Tartte V. Protective effect of centella triterpene saponins against cyclophosphamide-induced immune and hepatic system dysfunction in rats: its possible mechanisms of action. J Physiol Biochem. 2015 Sep;71(3):435-54. doi: 10.1007/s13105-015-0423-y.
Bennett RN, Mellon FA, Kroon PA. Screening crucifer seeds as sources of specific intact glucosinolates using ion-pair high-performance liquid chromatography negative ion electrospray mass spectrometry. J Agric Food Chem. 2004 Feb 11;52(3):428-38. doi: 10.1021/jf030530p.
Luque-Ortega JR, Martínez S, Saugar JM, Izquierdo LR, Abad T, Luis JG, et al. Fungus-elicited metabolites from plants as an enriched source for new leishmanicidal agents: antifungal phenyl-phenalenone phytoalexins from the banana plant (Musa acuminata) target mitochondria of Leishmania donovani promastigotes. Antimicrob Agents Chemother. 2004 May;48(5):1534-40. doi: 10.1128/AAC.48.5.1534-1540.2004.
Louzoun Y, Xue C, Lesinski GB, Friedman A. A mathematical model for pancreatic cancer growth and treatments. J Theor Biol. 2014 Jun 21;351:74-82. doi: 10.1016/j.jtbi.2014.02.028.
Oyeyinka BO, Afolayan AJ. Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules. Foods. 2022 Jul 29;11(15):2263. doi: 10.3390/foods11152263.
Kumar N, Ved A, Yadav RR, Prakash O. A Comprehensive Review on Phytochemical, Nutritional, and Therapeutic Importance of Musa acuminate. Int J Curr Res. 2021;13(09): 114–124.
Someya S, Yoshiki, Y, Okubo K. Antioxidant compounds from bananas (Musa Cavendish). Food Chem. 2002;79(3):351–354. doi: https://doi.org/https://doi.org/10.1016/S0308-8146(02)00186-3
Lopes RH, Macorini LF, Antunes KÁ, Espindola PP, Alfredo TM, da Rocha Pdos S et al. Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves. Oxid Med Cell Longev. 2016;2016:9681425. doi: 10.1155/2016/9681425.
Baskar R, Shrisakthi S, Sathyapriya B, Shyampriya R, Nithya R, Poongodi P. Antioxidant Potential of Peel Extracts of Banana Varieties (<i>Musa sapientum</i>). Food and Nutrition Sciences. 2011; 02(10): 1128–1133. doi:https://doi.org/10.4236/fns.2011.210151
Mohammed MA, Ibrahim BMM, Abdel-Latif Y, Hassan AH, El Raey MA, Hassan EM et al. Pharmacological and metabolomic profiles of Musa acuminata wastes as a new potential source of anti-ulcerative colitis agents. Sci Rep. 2022 Jun 22;12(1):10595. doi: 10.1038/s41598-022-14599-8.
Habotta O, Dawood MA O, Kari ZA, Tapingkae W, Van Doan H. Antioxidative and immunostimulant potntial of fruit derived biomolecules in aquaculture. Fish Shellfish Immunol. 2022; 130(August): 317–322. doi:https://doi.org/10.1016/j.fsi.2022.09.029
Apriasari ML, Pramitha SR, Puspitasari D, Ernawati DS. Anti-Inflammatory Effect of Musa acuminata Stem. Eur J Dent. 2020 Mar;14(2):294-298. doi: 10.1055/s-0040-1709944.
Accioly MP, Bevilaqua CM, Rondon FC, de Morais SM, Machado LK, Almeida CA et al. Leishmanicidal activity in vitro of Musa paradisiaca L. and Spondias mombin L. fractions. Vet Parasitol. 2012 Jun 8;187(1-2):79-84. doi: 10.1016/j.vetpar.2011.12.029.
Berawi KN, Bimandama MA. The Effect of Giving Extract Etanol of Kepok Banana Peel (Musa Acuminata) Toward Total Cholesterol Level on Male Mice (Mus Musculus L.) Strain Deutschland-Denken-Yoken (Ddy) Obese. Biomed Pharmacol J 2018;11(2).
Liyanage R, Gunasegaram S, Visvanathan R, Jayathilake C, Weththasinghe P, Jayawardana BC et al. Banana Blossom (Musa acuminate Colla) Incorporated Experimental Diets Modulate Serum Cholesterol and Serum Glucose Level in Wistar Rats Fed with Cholesterol. Cholesterol. 2016;2016:9747412. doi: 10.1155/2016/9747412.
Indriawati R, Atiyah FU. Antihyperglycemic and Hypolipidemic Potential of Kepok Banana Peel in Diabetic Rats. IOP Conference Series: Earth and Environmental Science. 2022; 985(1): 4–10. doi:https://doi.org/10.1088/1755-1315/985/1/012040
Abdullah FC, Rahimi L, Zakaria ZA, Ibrahim AL. Hepatoprotective, Antiulcerogenic, Cytotoxic and Antioxidant Activities of Musa acuminata Peel and Pulp. Novel Plant Bioresources: Applications in Food, Medicine and Cosmetics, John Wiley & Sons, UK. 2014.
Serafim C, Araruna ME, Alves Júnior E, Diniz M, Hiruma-Lima C, Batista L. A Review of the Role of Flavonoids in Peptic Ulcer (2010–2020). Molecules. 2020;25(22):1–32. doi:https://doi.org/10.3390/MOLECULES25225431
V B, S LK, S RK. Antioxidant and Anti-inflammatory Properties of the Two Varieties of Musa acuminata: An In Vitro Study. Cureus. 2023 Dec 28;15(12):e51260. doi: 10.7759/cureus.51260.
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