A NOVEL GRAPHENE OXIDE-PARA AMINO BENZOIC ACID NANOSHEET AS EFFECTIVE DRUG DELIVERY SYSTEM TO TREAT DRUG RESISTANT BACTERIA

Authors

  • Dipankar Ghosh Nanomaterials Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, 721302, India
  • Sourov Chandra Nanomaterials Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, 721302, India
  • Arindam Chakraborty Microbiology and Immunotechnology Laboratory, Department of Biotechnology, Indian Institute of Technology, Kharagpur, 721302, India
  • Sudip Kumar Ghosh Microbiology and Immunotechnology Laboratory, Department of Biotechnology, Indian Institute of Technology, Kharagpur, 721302, India
  • Panchanan Pramanik Nanomaterials Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, 721302, India

Abstract

A novel graphene oxide-para amino benzoic acid nanosheet was synthesized by modified chemical exfoliation of
expandable graphite using K2Cr2O7. Physico-chemical characteristics of graphene oxide-para-amino benzoic acid
nanosheet were determined by field emission scanning electron microscopy, fourier transform spectroscopy, fluorescence spectroscopy and biocompatibility assay. Experimental results showed that the average size and zeta potential of graphene oxide-para amino benzoic acid nanosheet sheets 100 nm and -34.9 (±7.03) mV, respectively. Afterwards, tetracycline drug loading efficiency and drug releasing efficiency were also monitored. Drug loading and drug releasing efficiency were found to be 64.075 (±2.74) and 38.35 (±0.07) %, respectively. Finally, antimicrobial activity of tetracycline loaded this nanosheet was determined in terms of minimal inhibitory concentration and putative mode of action on tetracycline resistant bacteria Escherichia coli XL-1. The minimal inhibitory concentration of this nanosheet was found to be 110µg/ml. Hence, it has been clearly shown that graphene oxide-para amino benzoic acid nanosheet has very unique features as drug delivery system to treat drug resistant bacteria.

Keywords:

graphene oxide, chemical exfoliation, minimal inhibitory concentration, drug delivery system

DOI

https://doi.org/10.25004/IJPSDR.2010.020209

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Published

01-04-2010
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How to Cite

“A NOVEL GRAPHENE OXIDE-PARA AMINO BENZOIC ACID NANOSHEET AS EFFECTIVE DRUG DELIVERY SYSTEM TO TREAT DRUG RESISTANT BACTERIA”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 2, Apr. 2010, pp. 127-33, https://doi.org/10.25004/IJPSDR.2010.020209.

Issue

Volume 2, Issue 2, 2010

Section

Research Article

Copyright (c) 2010 Dipankar Ghosh, Sourov Chandra, Arindam Chakraborty, Sudip Kumar Ghosh, Panchanan Pramanik

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

“A NOVEL GRAPHENE OXIDE-PARA AMINO BENZOIC ACID NANOSHEET AS EFFECTIVE DRUG DELIVERY SYSTEM TO TREAT DRUG RESISTANT BACTERIA”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 2, Apr. 2010, pp. 127-33, https://doi.org/10.25004/IJPSDR.2010.020209.