Alkaloids – Bridging Natural Products in Antidiabetic Therapy
Abstract
This review comprehensively evaluates the antidiabetic potential of alkaloids, their mechanisms of action, and their prospects as therapeutic agents for diabetes mellitus. A systematic review of published literature was conducted using databases including Elsevier, Science Direct, MDPI, Springers, and Taylor and Francis, focusing on alkaloids isolated from medicinal plants with reported antidiabetic activity, with botanical names validated via World Flora Online. Existing research revealed that alkaloids such as berberine and vindoline demonstrate significant antidiabetic effects through mechanisms like enhancing insulin sensitivity, stimulating insulin secretion, inhibiting digestive enzymes, and modulating gut microbiota. Notably, Berberis vulgaris L. and Coptis chinensis Franch. serve as key sources of berberine. In conclusion, alkaloids hold promise as supplementary or alternative therapies for diabetes mellitus, though further research is essential to fully elucidate their mechanisms and optimize clinical applications.
Keywords:
Diabetes Mellitus, Medicinal Plants, Alkaloids, Antidiabetic, Insulin Sensitivity, Oxidative StressDOI
https://doi.org/10.25004/References
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