A STUDY OF ANALGESIC AND ANTIMICROBIAL POTENTIAL OF MITRAGYNA PARVIFOLIA

Authors

  • D. Kaushik Faculty of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra- 136119, Haryana, India
  • S. L. Khokra Faculty of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra- 136119, Haryana, India 2
  • P. Kaushik Faculty of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra- 136119, Haryana, India 2
  • A. Saneja Faculty of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra- 136119, Haryana, India
  • C. Sharma Department of Microbiology, Kurukshetra University, Kurukshetra- 136119, Haryana, India 3
  • R. K. Aneja Department of Microbiology, Kurukshetra University, Kurukshetra- 136119, Haryana, India
  • B. Chaudhary Faculty of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra- 136119, Haryana, India
  • S. Koshy SRINIVAS College of Pharmacy, Mangalore, Karnataka- 574143, Karnataka, India

Abstract

The present study was designed to evaluate the analgesic and antimicrobial activities of ethanolic extract of leaves of
Mitragyna parvifolia plant (Rubiaceae) family. The analgesic activity was carried out on swiss albino male mice by Eddy’s
hot plate and Acetic acid induced writhing test. The extract showed only moderate analgesic potential in acetic acid
induced writhing test at all the test doses while the extract at the dose of 500 mg/kg (P<0.01) showed strong analgesic
activity comparable to standard drug Diclofenac sodium (50 mg/Kg, i.p.) in hot plate method. The extract in different
concentrations was also tested for antibacterial activity using agar well diffusion method. The extract significantly
inhibited S. aureus and showed some degree of inhibition against P. aeruginosa and E. coli.

Keywords:

Mitragyna parvifolia, Analgesic activity, Antimicrobial activity, Acetic acid induced writhing test

DOI

https://doi.org/10.25004/IJPSDR.2009.010102

References

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Published

01-04-2009
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How to Cite

“A STUDY OF ANALGESIC AND ANTIMICROBIAL POTENTIAL OF MITRAGYNA PARVIFOLIA”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 1, no. 1, Apr. 2009, pp. 6-8, https://doi.org/10.25004/IJPSDR.2009.010102.

Issue

Volume 1, Issue 1, 2009

Section

Research Article

Copyright (c) 2009 D. Kaushik, S. L. Khokra, P. Kaushik, A. Saneja, C. Sharma, R. K. Aneja, B. Chaudhary, S. Koshy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

“A STUDY OF ANALGESIC AND ANTIMICROBIAL POTENTIAL OF MITRAGYNA PARVIFOLIA”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 1, no. 1, Apr. 2009, pp. 6-8, https://doi.org/10.25004/IJPSDR.2009.010102.