ANTIMICROBIAL ACTIVITY OF THE LEAVES OF MYXOPYRUM SERRATULUM
Abstract
The antibacterial and antifungal activities of petroleum ether (40-60oC), benzene, chloroform, ethanol and water extracts of the leaves of Myxopyrum serratulum A. W. Hill. (Oleaceae) were tested for their antimicrobial activity in Agar diffusion assay. Significant antimicrobial activities were found against three gram positive bacteria, Streptococcus faecalis, Baccillus subtilis and Baccillus cereus, four gram negative bacteria; Klebsiella aerogens, Escherichia coli, Pseudomonas aeruginosa, Proteas vulgaris and two fungi, Candida albicans, Asparagillus flavans strains by using zone of inhibition assay. The activities were confirmed by Activity Index (AI). Activity Index values were found to be higher for ethanolic extract followed by the water extract. Among all the extracts tested; the ethanolic extract showed a good antimicrobial potential against microorganisms used in the study. The Minimum Inhibitory Concentration (MIC) for the ethanolic extract was also determined. The results support the ethnomedicinal use of Myxopyrum serratulum for the treatment of wounds and cuts.
Keywords:
Myxopyrum serratulum, Ethnomedicine, Antimicrobial, Zone of inhibition,, Minimum inhibitory concentrationDOI
https://doi.org/10.25004/IJPSDR.2012.040106References
2. Service RF. Antibiotics that resist resistance. Sci.1995; 270: 724-727.
3. Nascimento FGG, Locatelli J, Freitas PC, Silva GL. Antibacterial activity of plant extracts and phytochemicals on antibiotic resistant bacteria. Braz. J. Micro. 2000; 31: 247-256.
4. Orient Longman. Indian medicinal plants. Vol. 4: 2006, pp. 98-99.
5. Jain N, Sharma M. Broad spectrum antimycotic drug for the treatment of ringworm infection in human beings. Current Sciences. 2003; 85: 30-34.
6. Ayandele AA, Adebiyi AO. The phytochemical analysis and antimicrobial screening of extracts of Olax subscorpioidea. Afr. J Biotechnol. 2007; 6(7): 868-870.
7. Paniker, Anantharaman J. The text book of Microbiology, 7th edition, 2005, pp. 160.
8. Okeke MJ, Iroegbu CU, Eze EN, Okoli AS and Esimone CO. Evalution of extracts of the root of Landolpia owerrience for antibacterial activity. J. Ethanapharmacol. 2001; 78: 119-127.
9. Okuji CO, Okeke CN, Gugnani HC, and Jwu MM. Antifungal saponin from fruit pulp of Dracaena mnanni. Int.J. Crude Drug Res. 1990; 28:193-199.
10. Shadomy S, Espinel A. Manual of Clinical Microbiology. 4th edition, Washington, DC, 1980, pp. 647.
11. Majorie MC. Plant products as antimicrobial agents. Clin. Microbial. Rev. 1999; 12(4): 564-582.
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