EVALUATION OF ANTI-ULCER ACTIVITY OF METHANOLIC EXTRACT OF ABUTILON INDICUM LINN LEAVES IN EXPERIMENTAL RATS
Abstract
Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. In recent years, abundant work has been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. Here, present study was carried out to investigate antiulcer activity of methanol extract of Abutilon indicum L. (Family: Malvaceae) leaves in pylorus ligated and ethanol induced ulceration in the albino rats. Preliminary methanol extract of A. indicum was subjected to the acute oral toxicity study according to the OECD guideline no. 425. Based on which, two dose levels i.e. 250 and 500 mg/kg were selected for the further study. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for ethanol induced ulcer model. Ranitidine at 50 mg/kg was used as the standard drug. Pretreatment of methanol extract of A. indicum leaves showed significant (P<0.05) decrease in the gastric volume, total acidity and free acidity. However, pH of the gastric juice was significantly (P<0.05) increased only at higher dose, 500 mg/kg. It showed also significant (P<0.05) decrease in number of ulcers and ulcer score index in pylorus ligation and ethanol induced ulceration models. The methanol extract of A. indicum leaves possess significant antiulcer properties in a dose dependent manner. In conclusion the antiulcer properties of the extract may be attributed to the presence of phytochemicals like flavonoids (quercetin), alkaloids and tannins present in the plant extract with various biological activities.
Keywords:
Antiulcer activity, A. indicum, Pylorus ligation, Ulcer index.DOI
https://doi.org/10.25004/IJPSDR.2011.030205References
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