DIVERSE BELONGINGS OF CALENDULA OFFICINALIS: AN OVERVIEW
Abstract
Herbal drugs therapy is regarded as an important therapy for the treatment of a wide range of diseases. However, enormous improvements have been observed in modern systems of medicine, but Indian herbal plants provide a rich source for health care to prevent different pathological states. Calendula officinalis is an aromatic, erect, annual herb that is indigenous to Europe, cultivated commonly in North America, Balkans, Eastern Europe, Germany and India. Ample studies have reported about the anti-inflammatory, antioxidant, antitumour, antigenotoxic, chemoprotective and hepatoprotective potential associated with the drug. The review article describes about the various phytochemical constituents associated with the plant extract. Moreover, numerous pleiotropic effects exhibited by the plant have been clearly discussed.
Keywords:
Herbal, Calendula officinalis, Pleiotropic.DOI
https://doi.org/10.25004/IJPSDR.2011.030302References
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2. Gertsch J. Botanical Drugs, Synergy, and Network Pharmacology: Forth and Back to Intelligent Mixtures. Planta Med. 2011; in press.
3. Mukherjee PK, Maiti K, Mukherjee K, Houghton PJ. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol. 2006; 106: 1-28.
4. Basch E, Bent S, Foppa I, Haskmi S, Kroll D, Mele M, et al. Marigold (Calendula officinalis L.): an evidence-based systematic review by the Natural Standard Research Collaboration. J Herb Pharmacother. 2006; 6: 135-159.
5. Parente LM, Andrade MA, Brito LA, Moura VM, Miguel MP, Lino-Júnior Rde S, et al. Angiogenic activity of Calendula officinalis flowers L. in rats. Acta Cir Bras. 2011; 26: 19-24.
6. Kirtikar and Basu”s. Indian Medicinal Plants, 10. Revised and Enlarged, Edition IIIrd; 2000.
7. Kindersley D. The Encyclopedia of Medicinal Plants, A Practical Guide to Over 550 Key Herbs & their Medicinal Uses. First Published in Great Britan. 1996; 65.
8. Preethi KC, Kuttan R. Wound healing activity of flower extract of Calendula officinalis. J Basic Clin Physiol Pharmacol. 2009; 20: 73-79.
9. Fonseca YM, Catini CD, Vicentini FT, Cardoso JC, Cavalcanti De Albuquerque Junior RL, Vieira Fonseca MJ. Efficacy of marigold extract-loaded formulations against UV induced oxidative stress. J Pharm Sci. 2011; 100: 2182-2193.
10. Masterová I, Grancaiová Z. Phytochemical overview of the components of Calendula officinalis L. and their therapeutic evaluation. Cesk Farm. 1992; 41: 173-176.
11. Marukami T, Kishi A, Yoshikawa M. Medicinal flowers. IV. Marigold. (2): Structures of new ionone and sesquiterpene glycosides from Egyptian Calendula officinalis. Chem Pharm Bull. 2001a; 49: 974-978.
12. Liu J, Zhou Q, Wang S. Evaluation of chemical enhancement on phytoremediation effect of Cd-contaminated soils with Calendula officinalis L. Int J Phytoremediation. 2010; 12: 503-515.
13. Piccaglia R, Marotti M, Chi avari G, Gandini N. Effects of Harvesting Date and Climate on the Flavonoid and Carotenoid Contents of Marigold (Calendula officinalis L.). Flav Frag J 1997; 12: 85-90.
14. Szakiel A, Janiszowska W. Reversibility of the oleanolic acid monoglycosides transport across the tonoplast in vacuoles isolated from Calendula officinalis leaves. Acta Biochim Pol. 1997; 44: 55-59.
15. Bako E, Deli J, Toth G. HPLC study on the carotenoid composition of Calendula products. J Biochem Biophys Met. 2002; 53: 241-250.
16. Reed DW, Savile CK, Qiu X, Buist PH, Covello PS. Mechanism of 1,4 dehydrogenation catalyzed by a fatty acid (1,4)-desaturase of Calendula officinalis. Eur J Biochem. 2002; 269: 5024-5029.
17. Hamburger M, Adler S, Baumann D, Forg A, Weinreich B. Preparative purification of the major anti-inflammatory triterpenoid esters from Marigold (Calendula officinalis). Fitoterapia 2003; 74: 328-338.
18. Neukirch H, D'Ambrosio M, Dalla Via J, Guerriero A. Simultaneous quantitative determination of eight triterpenoid monoesters from flowers of 10 varieties of Calendula officinalis L. and characterisation of a new triterpenoid monoester. Phytochem Anal. 2004; 15: 30-35.
19. Kishimoto S, Maoka T, Sumitomo K, Ohmiya A. Analysis of carotenoid composition in petals of calendula (Calendula officinalis L.). Biosci Biotechnol Biochem. 2005; 69: 2122-2128.
20. Matysik G, Wojciak-Kosior M, Paduch R. The influence of Calendula officinalis flos extracts on cell cultures, and the chromatographic analysis of extracts. J Pharm Biomed Anal. 2005; 38: 285-292.
21. Della LR, Tubaro A, Sosa S, Becker H, Saar S, Isaac O. The role of triterpenoids in the topical anti-inflammatory activity of Calendula officinalis flowers. Planta Med. 1994; 60: 516-520.
22. Kalvatchev Z, Walder R, Garzaro D. Anti-HIV activity of extracts from Calendula officinalis flowers. Biomed Pharmacother. 1997; 51: 176-180.
23. Ramos A, Edreira A, Vizoso A, Betancourt J, López M, Décalo M. Genotoxicity of an extract of Calendula officinalis L. J Ethnopharmacol. 1998; 61: 49-55.
24. Marchenko MM, Kopyl'chuk HP, Hrygor'ieva OV. Activity of cytoplasmic proteinases from rat liver in Heren's carcinoma during tumor growth and treatment with medicinal herbs. Ukr Biokhim Zh. 2000; 72: 91-94.
25. Krazhan IA, Garazha NN. Treatment of chronic catarrhal gingivitis with polysorbimmobilized calendula. Stomatologiia. 2001; 80: 11-13.
26. Cordova CA, Siqueira IR, Netto CA, Yunes RA, Volpato AM, Cechinel Filho V, et al. Protective properties of butanolic extract of the Calendula officinalis L. (marigold) against lipid peroxidation of rat liver microsomes and action as free radical scavenger. Redox Rep. 2002; 7: 95-102.
27. Herold A, Cremer L, Calugaru A, Tamas V, Ionescu F, Manea S, et al. Antioxidant properties of some hydro-alcoholic plant extracts with anti-inflammatory activity. Roum Arch Microbiol Immunol. 2002; 62: 217-227.
28. Lin LT, Liu LT, Chiang LC, Lin CC. In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002; 16: 440-444.
29. Herold A, Cremer L, Calugaru A, Tamas V, Ionescu F, Manea S, et al. Hydro-alcoholic plant extracts with anti-inflammatory activity. Roum Arch Microbiol Immunol. 2003; 62: 117-129.
30. Iauk L, Lo Bue AM, Milazzo I, Rapisarda A, Blandino G. Antibacterial activity of medicinal plant extracts against periodontopathic bacteria. Phytother Res. 2003; 17: 599-604.
31. Barbour EK, Sagherian V, Talhouk S, Talhouk R, Farran MT, Sleiman FT, et al. Evaluation of homeopathy in broiler chickens exposed to live viral vaccines and administered Calendula officinalis extract. Med Sci Monit. 2004; 10: 281-285.
32. Chaparzadeh N, D'Amico ML, Khavari-Nejad RA, Izzo R, Navari-Izzo F. Antioxidative responses of Calendula officinalis under salinity conditions. Plant Physiol Biochem. 2004; 42: 695-701.
33. Pommier P, Gomez F, Sunyach MP, D'Hombres A, Carrie C, Montbarbon X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol. 2004; 22, 1447-1453.
34. Duran V, Matic M, Jovanovc M, Mimica N, Gajinov Z, Poljacki M, et al. Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. Int J Tissue React. 2005; 27: 101-106.
35. Ferreira A, Proenca C, Serralheiro ML, Araujo ME. The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. J Ethnopharmacol. 2006; 108: 31-37.
36. Fuchs SM, Schliemann-Willers S, Fischer TW, Elsner P. Protective effects of different marigold (Calendula officinalis L.) and rosemary cream preparations against sodium lauryl-sulfate-induced irritant contact dermatitis. Skin Pharmacol Physiol. 2005; 18, 195-200.
37. Rusu MA, Tamas M, Puica C, Roman I, Sabadas M. The hepatoprotective action of ten herbal extracts in CCl4 intoxicated liver. Phytother Res. 2005; 19: 744-749.
38. Barajas-Farias LM, Perez-Carreon JI, Arce-Popoca E, Fattel-Fazenda S, Aleman Lazarini L, Hernandez-Garcia S, et al. A dual and opposite effect of Calendula officinalis flower extract: chemoprotector and promoter in a rat hepatocarcinogenesis model. Planta Med. 2006; 72: 217-21.
39. Jimenez-Medina E, Garcia-Lora AM, Paco L, Algarra I, Collado A, Garrido F. A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation. BMC Cancer. 2006; 6: 119.
2. Gertsch J. Botanical Drugs, Synergy, and Network Pharmacology: Forth and Back to Intelligent Mixtures. Planta Med. 2011; in press.
3. Mukherjee PK, Maiti K, Mukherjee K, Houghton PJ. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol. 2006; 106: 1-28.
4. Basch E, Bent S, Foppa I, Haskmi S, Kroll D, Mele M, et al. Marigold (Calendula officinalis L.): an evidence-based systematic review by the Natural Standard Research Collaboration. J Herb Pharmacother. 2006; 6: 135-159.
5. Parente LM, Andrade MA, Brito LA, Moura VM, Miguel MP, Lino-Júnior Rde S, et al. Angiogenic activity of Calendula officinalis flowers L. in rats. Acta Cir Bras. 2011; 26: 19-24.
6. Kirtikar and Basu”s. Indian Medicinal Plants, 10. Revised and Enlarged, Edition IIIrd; 2000.
7. Kindersley D. The Encyclopedia of Medicinal Plants, A Practical Guide to Over 550 Key Herbs & their Medicinal Uses. First Published in Great Britan. 1996; 65.
8. Preethi KC, Kuttan R. Wound healing activity of flower extract of Calendula officinalis. J Basic Clin Physiol Pharmacol. 2009; 20: 73-79.
9. Fonseca YM, Catini CD, Vicentini FT, Cardoso JC, Cavalcanti De Albuquerque Junior RL, Vieira Fonseca MJ. Efficacy of marigold extract-loaded formulations against UV induced oxidative stress. J Pharm Sci. 2011; 100: 2182-2193.
10. Masterová I, Grancaiová Z. Phytochemical overview of the components of Calendula officinalis L. and their therapeutic evaluation. Cesk Farm. 1992; 41: 173-176.
11. Marukami T, Kishi A, Yoshikawa M. Medicinal flowers. IV. Marigold. (2): Structures of new ionone and sesquiterpene glycosides from Egyptian Calendula officinalis. Chem Pharm Bull. 2001a; 49: 974-978.
12. Liu J, Zhou Q, Wang S. Evaluation of chemical enhancement on phytoremediation effect of Cd-contaminated soils with Calendula officinalis L. Int J Phytoremediation. 2010; 12: 503-515.
13. Piccaglia R, Marotti M, Chi avari G, Gandini N. Effects of Harvesting Date and Climate on the Flavonoid and Carotenoid Contents of Marigold (Calendula officinalis L.). Flav Frag J 1997; 12: 85-90.
14. Szakiel A, Janiszowska W. Reversibility of the oleanolic acid monoglycosides transport across the tonoplast in vacuoles isolated from Calendula officinalis leaves. Acta Biochim Pol. 1997; 44: 55-59.
15. Bako E, Deli J, Toth G. HPLC study on the carotenoid composition of Calendula products. J Biochem Biophys Met. 2002; 53: 241-250.
16. Reed DW, Savile CK, Qiu X, Buist PH, Covello PS. Mechanism of 1,4 dehydrogenation catalyzed by a fatty acid (1,4)-desaturase of Calendula officinalis. Eur J Biochem. 2002; 269: 5024-5029.
17. Hamburger M, Adler S, Baumann D, Forg A, Weinreich B. Preparative purification of the major anti-inflammatory triterpenoid esters from Marigold (Calendula officinalis). Fitoterapia 2003; 74: 328-338.
18. Neukirch H, D'Ambrosio M, Dalla Via J, Guerriero A. Simultaneous quantitative determination of eight triterpenoid monoesters from flowers of 10 varieties of Calendula officinalis L. and characterisation of a new triterpenoid monoester. Phytochem Anal. 2004; 15: 30-35.
19. Kishimoto S, Maoka T, Sumitomo K, Ohmiya A. Analysis of carotenoid composition in petals of calendula (Calendula officinalis L.). Biosci Biotechnol Biochem. 2005; 69: 2122-2128.
20. Matysik G, Wojciak-Kosior M, Paduch R. The influence of Calendula officinalis flos extracts on cell cultures, and the chromatographic analysis of extracts. J Pharm Biomed Anal. 2005; 38: 285-292.
21. Della LR, Tubaro A, Sosa S, Becker H, Saar S, Isaac O. The role of triterpenoids in the topical anti-inflammatory activity of Calendula officinalis flowers. Planta Med. 1994; 60: 516-520.
22. Kalvatchev Z, Walder R, Garzaro D. Anti-HIV activity of extracts from Calendula officinalis flowers. Biomed Pharmacother. 1997; 51: 176-180.
23. Ramos A, Edreira A, Vizoso A, Betancourt J, López M, Décalo M. Genotoxicity of an extract of Calendula officinalis L. J Ethnopharmacol. 1998; 61: 49-55.
24. Marchenko MM, Kopyl'chuk HP, Hrygor'ieva OV. Activity of cytoplasmic proteinases from rat liver in Heren's carcinoma during tumor growth and treatment with medicinal herbs. Ukr Biokhim Zh. 2000; 72: 91-94.
25. Krazhan IA, Garazha NN. Treatment of chronic catarrhal gingivitis with polysorbimmobilized calendula. Stomatologiia. 2001; 80: 11-13.
26. Cordova CA, Siqueira IR, Netto CA, Yunes RA, Volpato AM, Cechinel Filho V, et al. Protective properties of butanolic extract of the Calendula officinalis L. (marigold) against lipid peroxidation of rat liver microsomes and action as free radical scavenger. Redox Rep. 2002; 7: 95-102.
27. Herold A, Cremer L, Calugaru A, Tamas V, Ionescu F, Manea S, et al. Antioxidant properties of some hydro-alcoholic plant extracts with anti-inflammatory activity. Roum Arch Microbiol Immunol. 2002; 62: 217-227.
28. Lin LT, Liu LT, Chiang LC, Lin CC. In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002; 16: 440-444.
29. Herold A, Cremer L, Calugaru A, Tamas V, Ionescu F, Manea S, et al. Hydro-alcoholic plant extracts with anti-inflammatory activity. Roum Arch Microbiol Immunol. 2003; 62: 117-129.
30. Iauk L, Lo Bue AM, Milazzo I, Rapisarda A, Blandino G. Antibacterial activity of medicinal plant extracts against periodontopathic bacteria. Phytother Res. 2003; 17: 599-604.
31. Barbour EK, Sagherian V, Talhouk S, Talhouk R, Farran MT, Sleiman FT, et al. Evaluation of homeopathy in broiler chickens exposed to live viral vaccines and administered Calendula officinalis extract. Med Sci Monit. 2004; 10: 281-285.
32. Chaparzadeh N, D'Amico ML, Khavari-Nejad RA, Izzo R, Navari-Izzo F. Antioxidative responses of Calendula officinalis under salinity conditions. Plant Physiol Biochem. 2004; 42: 695-701.
33. Pommier P, Gomez F, Sunyach MP, D'Hombres A, Carrie C, Montbarbon X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol. 2004; 22, 1447-1453.
34. Duran V, Matic M, Jovanovc M, Mimica N, Gajinov Z, Poljacki M, et al. Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. Int J Tissue React. 2005; 27: 101-106.
35. Ferreira A, Proenca C, Serralheiro ML, Araujo ME. The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. J Ethnopharmacol. 2006; 108: 31-37.
36. Fuchs SM, Schliemann-Willers S, Fischer TW, Elsner P. Protective effects of different marigold (Calendula officinalis L.) and rosemary cream preparations against sodium lauryl-sulfate-induced irritant contact dermatitis. Skin Pharmacol Physiol. 2005; 18, 195-200.
37. Rusu MA, Tamas M, Puica C, Roman I, Sabadas M. The hepatoprotective action of ten herbal extracts in CCl4 intoxicated liver. Phytother Res. 2005; 19: 744-749.
38. Barajas-Farias LM, Perez-Carreon JI, Arce-Popoca E, Fattel-Fazenda S, Aleman Lazarini L, Hernandez-Garcia S, et al. A dual and opposite effect of Calendula officinalis flower extract: chemoprotector and promoter in a rat hepatocarcinogenesis model. Planta Med. 2006; 72: 217-21.
39. Jimenez-Medina E, Garcia-Lora AM, Paco L, Algarra I, Collado A, Garrido F. A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation. BMC Cancer. 2006; 6: 119.
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01-07-2011
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“DIVERSE BELONGINGS OF CALENDULA OFFICINALIS: AN OVERVIEW”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 3, July 2011, pp. 173-7, https://doi.org/10.25004/IJPSDR.2011.030302.
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“DIVERSE BELONGINGS OF CALENDULA OFFICINALIS: AN OVERVIEW”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 3, July 2011, pp. 173-7, https://doi.org/10.25004/IJPSDR.2011.030302.
