EVALUATION OF ANTACID ACTIVITY OF MICROEMULSION FORMULATION OF BLEND OF ESSENTIAL OIL
Abstract
Essential oils are having wide range of biological activity is used to achieve therapeutic effects. These are volatile substances sensitive to oxygen, light, moisture and heat. In the present study microemulsion formulation was prepared using a blend of essential oil contains cardamom, coriander, fennel, caraway, ajowan and peppermint oil, water and non ionic surfactant tween 20 and cosurfactant as ethanol. Each essential oil was extracted from dried seed by steam distillation and characterized by Headspace Gas chromatography use of a marker compound which was linalool for coriander oil, cineol for cardamom oil, anethol for fennel oil, carvone for caraway oil, thymol for ajowan oil and menthol for peppermint oil. The marker compound was characterized using mass spectroscopy. Microemulsion of oil showed higher stability with droplet size in the range of 110-410nm. The product then screened for in vitro antacid properties which showed significant positive response.
Keywords:
Essential oil, Microemulsion, Steam distillation, Headspace gas chromatography, Antacid activityDOI
https://doi.org/10.25004/IJPSDR.2015.070206References
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11. Philip JM, Robert S, Charles C. Gas chromatographic technologies for the analysis of essential oils. Journal of Chromatography A 2001; 936: 1–22.
12. Luigi M, Alessandro C, Peter QT, Rosaria C, Paola D, Giovanni D. Fast GC for the Analysis of Citrus Oils. Journal of Chromatographic Science 2004; 42: 410-416.
13. Ghosh V, Mukherjee A, Chandrasekaran N. Formulation and Characterization of Plant Essential Oil Based Nanoemulsion Evaluation of its Larvicidal Activity against Aedes aegypti. Asian Journal of Chemistry 2013; 25: S321-S32.
14. Basheer HS, Noordin MI, Ghareeb MM. Characterization of Microemulsions Prepared using Isopropyl Palmitate with various Surfactants and Cosurfactants. Tropical Journal of Pharmaceutical Research 2013; 12(3):305-310.
15. Ghosh V, Mukherjee A, Chandrasekaran N. Mustard oil microemulsion formulation and evaluation of bactericidal activity. International Journal of Pharmacy and Pharmaceutical Sciences 2014; 16(2): 467-469.
16. Seth A, Maurya SK, Srivastava A. Formulation development, characterization & estimation of acid neutralization capacity of shankha bhasma tablets for the treatment of dyspepsia. International Journal of Pharmacy and Pharmaceutical Sciences 2012; 4(4):497-500.
17. Sharma S, Dwivedi J, Paliwal S. Evaluation of antacid and carminative properties of Cucumis sativus under simulated conditions. Scholars Research Library 2012; 4 (1):234-239.
2. Politeo O, Juki M, Milo M. Chemical Composition and Antioxidant Activity of Essential Oils of Twelve Spice Plants. Croat. Chem. Acta. 2006; 79(4): 545-552.
3. Mehdi H, Zeinab B, Saeide S, Yasub S. Antimicrobial activity of Trachyspermum ammi essential oil against human bacterial. International journal of Advanced Biological and Biomedical Research 2014; 2(1): 18-24.
4. Filomena S, Susana F, Joa o AQ, Fernanda CD. Coriander (Coriandrum sativum L.) essential oil: its antibacterial activity and mode of action evaluated by flow cytometry. Journal of Medical Microbiology 2011; 60: 1479-1486.
5. Wen RD, Qing PH, Hong ZA, Jian GX. Chemical composition, antibacterial activity and mechanism of action of essential oil from seeds of fennel (Foeniculum vulgare Mill.). Food Control 2014; 35: 109-116.
6. Keshavarz A, Minaiyan M, Ghannadi A, Mahzouni P. Effects of Carum carvi L. (Caraway) extract and essential oil on TNBS-induced colitis in rats. Research in Pharmaceutical Sciences 2013; 8(1): 1-8.
7. Anitescu G, Doneanu C, Radulescu V. Isolation of Coriander Oil: Comparison between Steam Distillation and Supercritical CO2 Extraction. Flavour and fragrance journal 1997; 12: 173-176.
8. Rathore SS, Saxena SN, Balraj S. Potential health benefits of major seed spices. International Journal Seed Spices 2013; 3(2): 1-12.
9. Mi Kyoung L, Jun HL, Mi-Hee C, Jin-Hyun J, Yoon-Cheol N, Kwang-Won L, Jee HJ, Jongki H. Simultaneous Determination of Biological Marker Compounds in Ostericum koreanum by HPLC Method and Discrimination by Principal Component Analysis. Bulletine Korean Chemical Socity 2008; 29(12) 2465 – 2470.
10. Mazumder J, Pathak D, Kumria R. Analytical Method Validation of an Herbal Formulation by Headspace Gas Chromatography Using QbD. International Journal of Pharmaceutical Sciences and Drug Research 2014; 6(4): 291-302.
11. Philip JM, Robert S, Charles C. Gas chromatographic technologies for the analysis of essential oils. Journal of Chromatography A 2001; 936: 1–22.
12. Luigi M, Alessandro C, Peter QT, Rosaria C, Paola D, Giovanni D. Fast GC for the Analysis of Citrus Oils. Journal of Chromatographic Science 2004; 42: 410-416.
13. Ghosh V, Mukherjee A, Chandrasekaran N. Formulation and Characterization of Plant Essential Oil Based Nanoemulsion Evaluation of its Larvicidal Activity against Aedes aegypti. Asian Journal of Chemistry 2013; 25: S321-S32.
14. Basheer HS, Noordin MI, Ghareeb MM. Characterization of Microemulsions Prepared using Isopropyl Palmitate with various Surfactants and Cosurfactants. Tropical Journal of Pharmaceutical Research 2013; 12(3):305-310.
15. Ghosh V, Mukherjee A, Chandrasekaran N. Mustard oil microemulsion formulation and evaluation of bactericidal activity. International Journal of Pharmacy and Pharmaceutical Sciences 2014; 16(2): 467-469.
16. Seth A, Maurya SK, Srivastava A. Formulation development, characterization & estimation of acid neutralization capacity of shankha bhasma tablets for the treatment of dyspepsia. International Journal of Pharmacy and Pharmaceutical Sciences 2012; 4(4):497-500.
17. Sharma S, Dwivedi J, Paliwal S. Evaluation of antacid and carminative properties of Cucumis sativus under simulated conditions. Scholars Research Library 2012; 4 (1):234-239.
Published
01-03-2015
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“EVALUATION OF ANTACID ACTIVITY OF MICROEMULSION FORMULATION OF BLEND OF ESSENTIAL OIL”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 2, Mar. 2015, pp. 163-7, https://doi.org/10.25004/IJPSDR.2015.070206.
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How to Cite
“EVALUATION OF ANTACID ACTIVITY OF MICROEMULSION FORMULATION OF BLEND OF ESSENTIAL OIL”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 2, Mar. 2015, pp. 163-7, https://doi.org/10.25004/IJPSDR.2015.070206.
