SEARCH FOR BIOLOGICAL ACTIVE ISATINS: A SHORT REVIEW
Abstract
Isatin and its analogs are versatile substrates, which can be used for the synthesis of numerous heterocyclic compounds. Isatin and its derivatives are used in organic synthesis and they are used in evaluating new product that possesses different biological activities. In the past few decades, Isatin and its derivatives have received much attention due to their chemotherapeutic values. This review covers updated information on the most active isatin derivatives that have been reported to show considerable pharmacological actions such as antimicrobial, anticancer, antiviral, anticonvulsant, anti-inflammatory and analgesic. From these results, ideas for future molecular modifications leading to compounds with greater favorable pharmacological properties may be derived.
Keywords:
Isatin derivatives, antimicrobial, anticancer, antiviral, anticonvulsant, anti-HIVDOI
https://doi.org/10.25004/IJPSDR.2010.020402References
Manna K, Aggarwal Y. Microwave assisted synthesis of new indophenazine 1, 3, 5-trisubstituted pyrrazoline derivatives of benzofuran and their antimicrobial activity. Bioorg. Med. Chem. Lett. 2009; 19: 2688-2692.
Pandeya SN, Kumar R, Pathak AK, Nath G. Synthesis and biological evaluation of triazine derivatives. Der. Pharm. Chem.2010; 2(2): 257-266.
Rahman AHA, Keshk EM, Hanna MA. Synthesis and evaluation of some new spiroindoline based hetrocycles as potentially active antimicrobial. Bioorg. Med. Chem. 2004; 12: 2483-2488.
Singh GS, Luntha P. Synthesis and antimicrobial activity of new 1-alkyl/cyclohexyl-3, 3-diaryl-1’-methylspiro [azetidine-2, 3’-indoline]-2’, 4-diones. Euro. J. Med. Chem. 2009; 44: 2265-2269.
Patel A, Bari S, Talele G, Patel J. Synthesis and antimicrobial activity of some new isatin derivatives. Iran. J. Pharm. Res. 2006; 4:249-254.
Pardasani RT, Pardasani P, Muktawat S, Chaturvedi V. Reaction of 2-thiozoline-2-thiol with isatin derivatives. Phosp. Silic. Sulp.1998; 142: 221-227.
Olomola TO, Bada DA. Synthesis and antibacterial activity of two spiro[indole] thiadiazole derivatives. Toxi. Environ. Chem.2009; 91(5):941-946.
Pandeya SN, Sriram D, Nath G. Synthesis, antibacterial, antifungal and anti-HIV activity of norfloxacin mannich bases Euro. J. Med. Chem. 2000; 35: 249-255.
Vine KL, Locke JM, Ronson M. In vitro cytotoxicity evaluation of some substituted isatin derivatives. Bioorg. Med. Chem.2007; 15: 931-938.
Solomon VR, Lee C, Hu H. Hybrid pharmacophore design and synthesis of isatinbenzothiazole analogs for their anti-breast cancer activity. Bioorg. Med. Chem. 2009; 17: 7585-7592.
Wee XK, Yeo WK, Zhang B, Tan VBC. Synthesis and evaluation of functionalized isoindigo as antiproliferative agents. Bioorg. Med. Chem. 2009; 17: 7561-7562.
Ge P, Kalwan TI. Design and Synthesis of 3,5-dialkylamino substituted 8H, 10H-3(R), 15b (S)-2,3,6,7-tetrahydro-1,5,3-dioxoazepino[3,2-c]indolo[3,2-g]pteridine-7-ones. Bioorg. Med. Chem. Lett.1997; 7(23): 3023-3026.
Shibinskya MO, Lyakhov SA, Mazepa AV, Andronati SA. Synthesis, Cytotoxicity, Antiviral activity and interferon inducing ability of 6-(2-aminomethyl)-6H-indolo [2, 3-b] quinoxalines. Euro. J. Med. Chem. 2010; 45: 1237-1243.
Chen LR, Wang YC, Lin YW, Chou SY, Chen SF. Synthesis and evaluation of isatin derivatives as effective SARS Coronavirus 3CL protease inhibitors. Bioorg. Med. Chem. Lett. 2005; 15: 3058-3062.
Andrieu BM, Merour JY. Reaction of 3-([(triflouromethyl)sulfonyl]oxy)-1H –indole derivatives with diamines and carbon nucleophiles, synthesis of 6H-indolo[2,3-b] quinoxaline derivatives. Tetrah. 1998; 54: 11095-11110.
Sin N, Venables BL, Combrink KD, Gulgeze HB, Yu KL, Civiello RL. Respiratory, syncytial virus fusion inhibitors part 7, structure activity relationship with a series of isatin oximes that demonstrate antiviral activity invivo. Bioorg. Med. Chem. Lett. 2009; 19:4857-4862.
Sriram D, Yogeeswari P, Gopal G. Synthesis, anti HIV and antitubercular activity of lamivudine prodrugs. Euro. J. Med. Chem. 2005; 40:1373-1376.
Oliveira MRP, Torres SC, Garden SV, Santos CVB, Alves TR. Synthesis and antiviral evaluation of isatin Ribonucleosides. Nucle. Nucleio. Nucleic acid. 2002; 11(12): 825-835.
Palluotto F, Carotti A, Casini G, Camagna F, Genchi G. Structure activity relationship of 2-aryl-2, 5 dihydropyridazino [4,3-b] indol-3(3H)-ones at the benzodiazepine receptor. Bioorg. Med. Chem .1996; 4(12): 2091-2104.
Campagna F, Carotti A, Casini G, Palluotto F, Genchi G, Sarro GBD. 2-Aryl-2, 5-dihydropyridazino [4,3-b] indol-3(3-H) ones. Bioorg. Med. Chem.1993; 1(6): 437-446.
Ragavendran JV, Sriram D, Patel SK, Reddy IV, Bhathwajan N. Design and synthesis and anticonvulsant activity from a combined phthalamide-GABA-anilide and hydrazone pharmacophore. Euro. J. Med. Chem.2007; 42: 146-151.
Azam F, Alkskas IA, Khokra SL, Prakash O. Synthesis of some novel N4-(naphtha [1, 2-d]thiazol-2yl) semicarbazides as potential anticonvulsants. Euro. J. Med. Chem. 2009; 44: 203-211.
Sridhar SK, Pandeya SN, Stables JP, Ramesh A. Anticonvulsant activity of hydrazones, Schiff and mannich bases of isatin derivatives. Euro. J. Pharm. Sci. 2002; 16: 129-132.
Raj M, Veerasamy N, Singh VK. Highly enantioselective synthesis of 3-cycloalkanone-3-hydroxy-2-oxindoles, potential anticonvulsants. Tetrah. Lett. 2010; 51: 2157-2159.
Panneerselvam P, Reddy RS, Murali K, Kumar NR. Synthesis, analgesic, anti-inflammatory, and antimicrobial activities of 5-sustituted isatin derivatives. Der Pharm. Chem. 2010; 2(1): 28-37.
Matheus ME, Violante FDA, Garden SJ, Pinto AC. Isatin inhibit cyclooxygenase-2 and inducible nitric oxide synthase in a mouse macrophage cell-line. Euro. J. Pharmcol. 2007; 556: 200-206.
Chiyanzu I, Clarkson C, Smith PJ, Lehman J. Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives. Bioorg. Med. Chem. Lett.2005; 13: 3249-3261.
Sriram D, Yogeeswari P, Gopal G. Synthesis, anti-HIV and antitubercular activities of lamivudine prodrugs. Euro. J. Med. Chem. 2005; 40: 1373-1376.
Andreani A, Burnelli S, Granaiola M, Leoni A. New isatin derivatives with antioxidant activity. Euro. J. Med. Chem. 2010; 45: 1374-1378.
Bal TR, Anand B, Yogeeswari P, Sriram D. Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivatives. Bioorg. Med. Chem. Lett. 2005; 15: 4451-4455.
Pawar VS, Lokwani DL, Bhandari SV, Bothara KG. Design, docking study and ADME prediction of isatin derivatives as anti HIV agents. Med. Chem. Res. 2010. DOI 10.1007/S00044-010-9329-Y.
Reddy RK. Cobalt (II), Ni (II), Zn (II), CD (II), Hg (II) and UO2 (VI) complexes from on Schiff base ligand. J. Chil. Chem. Soc.2008; 53(4): 1653-1657.
Published
Abstract Display: 601 
PDF Downloads: 621 
