CHOOSING AN APPROPRIATE METHOD FOR SUSTAINED RELEASE FLURBIPROFEN PELLET PRODUCTION
Abstract
Flurbiprofen is a slightly water soluble, nonsteroidal anti-inflammatory active ingredient with analgesic and antipyretic activity. The purpose of this study was to develop an appropriate pellet production method for pH independent sustained release pellet formulation of flurbiprofen. Flurbiprofen pellets were produced by three different production methods; Suspension Layering, Extrusion Spherization, Rotagranulation. Although the simple and fast processing properties of Extrusion Spheronization and Rotagranulation methods, according to visual control and comparative dissolution profiles, Suspension Layering method was found more suitable for Flurbiprofen SR (Sustained Release) having high drug load for each single dose. Beginning with the spherical core has brought great advantage to Suspension Layering method, since ideal sphericity could not be reached at Extrusion Spheronization and Rotagranulation methods due to limited microcrystalline cellulose amount.
Keywords:
Controlled release, Flurbiprofen SR pellet, Pelletization techniques, Suspension Layering, Extrusion Spheronization, RotagranulationDOI
https://doi.org/10.25004/IJPSDR.2015.070404References
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7. Vervaet C, Lieven B, Remon JP. Extrusion-Spheronization A literature review. International journal of pharmaceutics 1995; 116(2): 131-146.
8. Kandukuri JM, Allenki V, Eaga CM, Keshetty V, Jannu KK. Pelletization Techniques for Oral Drug Delivery. International Journal of Pharmaceutical Sciences and Drug Research 2009; 1(2): 63-70.
9. Bhowmik D, Gopinath H, Kumar BP, Duraivel S, Kumar KPS. Controlled Release Drug Delivery Systems. The Pharma Innovation 2012; 1(10): 24-32.
10. Kushal M, Monali M, Durgavati M, Mittal P, Umesh S, Pragna S. Oral Controlled Release Drug Delivery System: An Overview. International Research Journal of Pharmacy 2013; 4(3): 70-76.
11. Ummadi S, Shravani B, Rao NGR, Reddy MS, Nayak BS. Overview on Controlled Release Dosage Form. International Journal of Pharma Sciences 2013; 3(4): 258-269.
12. Dey NS, Majumdar S, Rao MEB. Multiparticulate Drug Delivery Systems for Controlled Release. Tropical Journal of Pharmaceutical Research 2008; 7(3): 1067-1075
13. Madhav NVS, Kala S. Review on Multiparticulate Drug Delivery System. International Journal of PharmTech Research 2011; 3(3): 1242-1254.
14. Dixit N, Maurya SD, Sagar BPS. Sustained Release Drug Delivery System. Indian Journal of Research in Pharmacy and Biotechnology. 2013; 1(3):305-310.
15. Koester M, Thommes M. New Insights into the Pelletization Mechanism by Extrusion/Spheronization. AAPS PharmSciTech. 2010; 11(4): 1549-1551.
16. Korakianiti ES, Rekkas DM, Dallas PP, Choulis NH. Optimization of the Pelletization Process in a Fluid-Bed Rotor Granulator Using Experimental Design. AAPS PharmSciTech. 2000; 1(4) article 35.
17. Nastruzzi C, Cortesi R, Esposito E, Genovesi A, Spadoni A, Vecchio C, Menegatti E. Influence of Formulation and Process Parameters on Pellet Production by Powder Layering Technique. AAPS PharmSciTech 2000; 1(2) article 9.
18. Haritha VVN. Multiparticulate Drug Delivery System: Pelletization. American Journal of PharmTech Research 2012; 2(1): 81-87.
19. Manivannan R, Parthiban KG, Sandeep G, Balasubramaniam A, Senthilkumar N. Multiparticlate drug delivery systems: Pellet & pelletization technique. Drug Invention Today 2010; 2(5): 233-237.
20. Abdul S, Chandewar AV, Jaiswal SB. A flexible technology for modified-release drugs: Multiple-unit pellet system (MUPS). Journal of Controlled Release 2010; 147: 2–16.
21. Kallai N, Luhn O, Dredan J, Kovacs K, Lengyel M, Antal I. Evaluation of Drug Release From Coated Pellets Based on Isomalt, Sugar, and Microcrystalline Cellulose Inert Cores. AAPS PharmSciTech. 2010; 11(1): 383-391.
2. Nanjwade BK, Multiparticulate drug delivery systems, Retrieved May 4, 2015, from http://www.slideshare.net/bknanjwade/multiparticulate-drug-delivery-systems.
3. Hirjau M, Nicoara AC, Hirjau V, Lupuleasa D. Pelletization techniques used in pharmaceutical fields. Farma. 2011; 4(3): 4.
4. Goodhart FW. Pharmaceutical Pelletization Technology. Drugs and the Pharmaceutical Sciences Volume 37. eds. Ghebre – Sellassie I, Marcel Dekker INC. 1989, pp. 101-122.
5. Jones DM. Pharmaceutical Pelletization Technology, Drugs and the Pharmaceutical Sciences Volume 37, eds. Ghebre – Sellassie I, Marcel Dekker INC. 1989, pp. 145-164.
6. Supriya P, Rajni B, Rana AC. Pelletization techniques: a literature review. International Research Journal of Pharmacy 2012; 3(3): 43-47.
7. Vervaet C, Lieven B, Remon JP. Extrusion-Spheronization A literature review. International journal of pharmaceutics 1995; 116(2): 131-146.
8. Kandukuri JM, Allenki V, Eaga CM, Keshetty V, Jannu KK. Pelletization Techniques for Oral Drug Delivery. International Journal of Pharmaceutical Sciences and Drug Research 2009; 1(2): 63-70.
9. Bhowmik D, Gopinath H, Kumar BP, Duraivel S, Kumar KPS. Controlled Release Drug Delivery Systems. The Pharma Innovation 2012; 1(10): 24-32.
10. Kushal M, Monali M, Durgavati M, Mittal P, Umesh S, Pragna S. Oral Controlled Release Drug Delivery System: An Overview. International Research Journal of Pharmacy 2013; 4(3): 70-76.
11. Ummadi S, Shravani B, Rao NGR, Reddy MS, Nayak BS. Overview on Controlled Release Dosage Form. International Journal of Pharma Sciences 2013; 3(4): 258-269.
12. Dey NS, Majumdar S, Rao MEB. Multiparticulate Drug Delivery Systems for Controlled Release. Tropical Journal of Pharmaceutical Research 2008; 7(3): 1067-1075
13. Madhav NVS, Kala S. Review on Multiparticulate Drug Delivery System. International Journal of PharmTech Research 2011; 3(3): 1242-1254.
14. Dixit N, Maurya SD, Sagar BPS. Sustained Release Drug Delivery System. Indian Journal of Research in Pharmacy and Biotechnology. 2013; 1(3):305-310.
15. Koester M, Thommes M. New Insights into the Pelletization Mechanism by Extrusion/Spheronization. AAPS PharmSciTech. 2010; 11(4): 1549-1551.
16. Korakianiti ES, Rekkas DM, Dallas PP, Choulis NH. Optimization of the Pelletization Process in a Fluid-Bed Rotor Granulator Using Experimental Design. AAPS PharmSciTech. 2000; 1(4) article 35.
17. Nastruzzi C, Cortesi R, Esposito E, Genovesi A, Spadoni A, Vecchio C, Menegatti E. Influence of Formulation and Process Parameters on Pellet Production by Powder Layering Technique. AAPS PharmSciTech 2000; 1(2) article 9.
18. Haritha VVN. Multiparticulate Drug Delivery System: Pelletization. American Journal of PharmTech Research 2012; 2(1): 81-87.
19. Manivannan R, Parthiban KG, Sandeep G, Balasubramaniam A, Senthilkumar N. Multiparticlate drug delivery systems: Pellet & pelletization technique. Drug Invention Today 2010; 2(5): 233-237.
20. Abdul S, Chandewar AV, Jaiswal SB. A flexible technology for modified-release drugs: Multiple-unit pellet system (MUPS). Journal of Controlled Release 2010; 147: 2–16.
21. Kallai N, Luhn O, Dredan J, Kovacs K, Lengyel M, Antal I. Evaluation of Drug Release From Coated Pellets Based on Isomalt, Sugar, and Microcrystalline Cellulose Inert Cores. AAPS PharmSciTech. 2010; 11(1): 383-391.
Published
01-11-2015
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“CHOOSING AN APPROPRIATE METHOD FOR SUSTAINED RELEASE FLURBIPROFEN PELLET PRODUCTION”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 4, Nov. 2015, pp. 329-33, https://doi.org/10.25004/IJPSDR.2015.070404.
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How to Cite
“CHOOSING AN APPROPRIATE METHOD FOR SUSTAINED RELEASE FLURBIPROFEN PELLET PRODUCTION”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 4, Nov. 2015, pp. 329-33, https://doi.org/10.25004/IJPSDR.2015.070404.
