ANTIULCER ACTIVITY OF METHANOLIC EXTRACT OF ROOTS OF BETA VULGARIS, CHENOPODIACEAE
Abstract
Beta vulgaris (chenopodiacea) is a medicinal plant reported for its variety of ethnic medicinal uses. Beta vulgaris showed antioxidant, anticancer, hepatoprotective, nephroprotective, wound healing, and anti-inflammatory activities. Hence we have planned to screen antiulcer activity of root of the plant with the methanolic extract. Root powders successively extracted with methyl alcohol and were subjected for phytochemical screening to identify different phytoconstituents. The methanolic extracts of roots of Beta vulgaris were investigated for ulcer protective activity against pyloric-ligation, ethanol induced gastric lesion and cold restraint stress induced ulcers. Preliminary phytochemical screening revealed the presence of flavonoids, saponins, sterols, and alkaloids. The extract was tested for their lethal effect up to the dose level of 2000 mg/kg. None of them have produced abnormal behavior or mortality in rats. Further methanolic extract of 200 and 400 mg/kg/p.o significantly (p˂0.01) reduced the ulcer score, ulcer number, ulcer index, free acidity and total acidity in pyloric-ligation, ethanol induced gastric lesion and cold restraint stress induced ulcer models in rats. The present study revealed that the root extract of Beta vulgaris has antiulcer activity.
Keywords:
Pyloric-ligation, gastric lesion, ulceration, wound healingDOI
https://doi.org/10.25004/IJPSDR.2018.100605References
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