STANDARDIZATION AND ASSESSMENT OF PREFORMULATION PARAMETERS OF RASAYANA TABLET
Abstract
Rasayana tablet is a polyherbal preparation recommended as a tonic. It contains Amla, Gokhru and Galo in equal proportion. This preparation is generally marketed in the form of churna and tablet with several problems in weight hardness, disintegration time and friability. The present work is based on the Standardization of individual ingredients and formulation of Rasayana tablets with improved formulation parameters in order to compare it with the marketed formulation. Pharmacognostical parameters were also checked for individual crude drugs and marketed tablets like ash value, extractive value, loss on drying and powder microscopy. The preformulation parameters like bulk density, tap density, Carr’s index, Hausner’s ratio and angle of repose were also checked for laboratory granules. The tablets were prepared by wet granulation technique using sucrose (55 % solution) and starch (20 % solution) as binder. The designed formulations were evaluated for thickness, diameter, hardness, friability and disintegration time. The designed formulation was in conformity to the properties evaluated for the tablets and is discussed in detail.
Keywords:
Rasayana tablet, wet granulation, density, Carr’s indexDOI
https://doi.org/10.25004/IJPSDR.2010.020113References
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