SPECTROPHOTOMETRIC QUANTITATIVE ESTIMATION AND VALIDATION OF NIMESULIDE AND DROTAVERINE HYDROCHLORIDE IN TABLET DOSAGE FORM
Abstract
Three simple, sensitive and accurate UV spectrophotometric methods, I; first order derivative spectrophotometric, II; area under curve and III; multi-component method, has been developed for the estimation of drotaverine hydrochloride and nimesulide in tablets dosage form. Beers’ law was obeyed in the concentration range 5-35 µgml-1 and 10-50 µgml-1 for drotaverine (λmax = 230.5 nm) and nimesulide (λmax = 331.5 nm) respectively in methanol. All the three methods allowed rapid analysis of binary pharmaceutical formulation with accuracy. Results of analysis for three methods were tested and validated for various parameters according to ICH guidelines.
Keywords:
Drotaverine hydrochloride, Nimesulide, Derivative spectrophotometric method, Area under curve method, Multi-component methodDOI
https://doi.org/10.25004/IJPSDR.2010.020115References
1. Chandran S, Saggar S, Priya KP, Ranendra N. New Ultraviolet Spectrophotometric Method for the Estimation of Nimesulide Drug Development, Industrial Pharmacy 2000; 26(2): 229-234.
2. Altino S, Dursun OO. Determination of nimesulide in pharmaceutical dosage forms by second order derivative UV spectrophotometry. J. Pharm Biomed Ana. 2000; 22:175–182.
3. Ashok K, Anroop B, Vijay KS. A Spectrophotometric method for simultaneous estimation of Nimesulide and Paracetamol in Tablet Dosage form, Indian drug 2003; 40 (12): 727-729.
4. Chilukuri S, Lakshmi R, Reddy MN. Spectrophotometric Estimation of Nimesulide and its Formulations. Microchem. Acta. 1999; 132 (1):1-6.
5. Indrajeet S. Spectrophotometric and HPLC methods for simultaneous estimation of nimesulide and paracetamol from tablets. Philippine J. Sci. 2002; 131(1): 59-64.
6. Hemlata M, Wate SP, Dharkar DP, Razdan R. Simultaneous RP-HPLC determination of Nimesulide and Tizanidine in Tablets. Indian J. Pharm. Sci. 2007; 69 (2): 281-183.
7. Patravale VB, D'Souza S, Yogeeta N. HPTLC determination of nimesulide from pharmaceutical dosage forms. J. Phram. Biomed. Ana. 2001; 25 (3-4):685-688.
8. Nagoji KEV, Vijayasrinivas S, Kumar KM, Mathivanan N, Kumar SM, Rao MEB. Simultaneous reverse phase HPLC estimation of nimesulide and diclofenac sodium. Indian J. Pharm. Sci. 2003; 65(4):407-409.
9. Castoldi D, Monzani V, Tofanetti O, Simultaneous determination of nimesulide and hydroxynimesulide in human plasma and urine by high-performance liquid chromatography. J. Chromatogr. 1988; 425 (2):413-8.
10. Khaksa G, Udupa N, Rapid and sensitive method for determination of nimesulide in human plasma by high-performance liquid chromatography. J. Chromatgr B: Biomed. Sci. Appl. 1999; 727 (1-2):241-244.
11. Budavari S, Smith A, Heckelman PE. In: The Merk Index: An Encyclopedia of Chemicals, Drugs and Biological, merck & Co., Inc. Whiehouse Station, New Jersey. 2001.
12. Lalla JK, Shah MU, Jain MB, Sharma AH. Modified HPLC method for analysis of Drotaverine in human plasma. J. Pharm. Biomed. Ana. 1993; 11 (4-5):385-388.
13. Bolaji OO, Onyeji CO. HPLC method for determination of drotaverine hydrochloride in human plasma and urine. Journal Chromatogr. Biomed. Appl., 1993; 622(1): 93-97.
14. Mahajan VK, Dahivelkar PP, Fursule RA, Shirkhedkar AA, Surana SJ. Spectrophotometric method for estimation of Drotaverine hydrochloride in bulk and tablet formulation. Indian drugs 2006; 43(8): 656-659.
15. Amin. AS, Sheikh RE, Faten Z, Ayman AEG. Spectrophotometric determination of Pipezethate HCl, Dextromethrophan HBr and Drotaverine HCl in their pharmaceutical preparation. Spectrochim Acta A Mol biomol spectrosc, 2007; 6-7(3-4): 1088-1093.
16. Abdellatef HE, Ayad MM, Soliman SM, Youssef NF. Spectrophotometric and Spectrodensitometric determination of paracetamol and drotaverine HCl in combination. Spectrochim Acta A Mol Biomol Spectrosc. 2007; 66 (4-5): 1147-51.
17. Jain HK, Agrawal RK. Simultaneous estimation of gliclazide and metformine hydrochloride in combined dosage forms. Ind. J. Pharm. Sci. 2002; 64 (1): 88-91.
18. Chepurwar SB, Shirkhedkor AA, Bari SB, Surana SJ. Spectrophotometric methods for simultaneous estimation of Levofloxacine and Ornidazole in Tablet Dosage form. Indian Drugs 2006; 43(10):803-807
2. Altino S, Dursun OO. Determination of nimesulide in pharmaceutical dosage forms by second order derivative UV spectrophotometry. J. Pharm Biomed Ana. 2000; 22:175–182.
3. Ashok K, Anroop B, Vijay KS. A Spectrophotometric method for simultaneous estimation of Nimesulide and Paracetamol in Tablet Dosage form, Indian drug 2003; 40 (12): 727-729.
4. Chilukuri S, Lakshmi R, Reddy MN. Spectrophotometric Estimation of Nimesulide and its Formulations. Microchem. Acta. 1999; 132 (1):1-6.
5. Indrajeet S. Spectrophotometric and HPLC methods for simultaneous estimation of nimesulide and paracetamol from tablets. Philippine J. Sci. 2002; 131(1): 59-64.
6. Hemlata M, Wate SP, Dharkar DP, Razdan R. Simultaneous RP-HPLC determination of Nimesulide and Tizanidine in Tablets. Indian J. Pharm. Sci. 2007; 69 (2): 281-183.
7. Patravale VB, D'Souza S, Yogeeta N. HPTLC determination of nimesulide from pharmaceutical dosage forms. J. Phram. Biomed. Ana. 2001; 25 (3-4):685-688.
8. Nagoji KEV, Vijayasrinivas S, Kumar KM, Mathivanan N, Kumar SM, Rao MEB. Simultaneous reverse phase HPLC estimation of nimesulide and diclofenac sodium. Indian J. Pharm. Sci. 2003; 65(4):407-409.
9. Castoldi D, Monzani V, Tofanetti O, Simultaneous determination of nimesulide and hydroxynimesulide in human plasma and urine by high-performance liquid chromatography. J. Chromatogr. 1988; 425 (2):413-8.
10. Khaksa G, Udupa N, Rapid and sensitive method for determination of nimesulide in human plasma by high-performance liquid chromatography. J. Chromatgr B: Biomed. Sci. Appl. 1999; 727 (1-2):241-244.
11. Budavari S, Smith A, Heckelman PE. In: The Merk Index: An Encyclopedia of Chemicals, Drugs and Biological, merck & Co., Inc. Whiehouse Station, New Jersey. 2001.
12. Lalla JK, Shah MU, Jain MB, Sharma AH. Modified HPLC method for analysis of Drotaverine in human plasma. J. Pharm. Biomed. Ana. 1993; 11 (4-5):385-388.
13. Bolaji OO, Onyeji CO. HPLC method for determination of drotaverine hydrochloride in human plasma and urine. Journal Chromatogr. Biomed. Appl., 1993; 622(1): 93-97.
14. Mahajan VK, Dahivelkar PP, Fursule RA, Shirkhedkar AA, Surana SJ. Spectrophotometric method for estimation of Drotaverine hydrochloride in bulk and tablet formulation. Indian drugs 2006; 43(8): 656-659.
15. Amin. AS, Sheikh RE, Faten Z, Ayman AEG. Spectrophotometric determination of Pipezethate HCl, Dextromethrophan HBr and Drotaverine HCl in their pharmaceutical preparation. Spectrochim Acta A Mol biomol spectrosc, 2007; 6-7(3-4): 1088-1093.
16. Abdellatef HE, Ayad MM, Soliman SM, Youssef NF. Spectrophotometric and Spectrodensitometric determination of paracetamol and drotaverine HCl in combination. Spectrochim Acta A Mol Biomol Spectrosc. 2007; 66 (4-5): 1147-51.
17. Jain HK, Agrawal RK. Simultaneous estimation of gliclazide and metformine hydrochloride in combined dosage forms. Ind. J. Pharm. Sci. 2002; 64 (1): 88-91.
18. Chepurwar SB, Shirkhedkor AA, Bari SB, Surana SJ. Spectrophotometric methods for simultaneous estimation of Levofloxacine and Ornidazole in Tablet Dosage form. Indian Drugs 2006; 43(10):803-807
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01-01-2010
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“SPECTROPHOTOMETRIC QUANTITATIVE ESTIMATION AND VALIDATION OF NIMESULIDE AND DROTAVERINE HYDROCHLORIDE IN TABLET DOSAGE FORM”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 1, Jan. 2010, pp. 67-70, https://doi.org/10.25004/IJPSDR.2010.020115.
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Copyright (c) 2010 K. R. Prasad, R. Sharma
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
“SPECTROPHOTOMETRIC QUANTITATIVE ESTIMATION AND VALIDATION OF NIMESULIDE AND DROTAVERINE HYDROCHLORIDE IN TABLET DOSAGE FORM”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 1, Jan. 2010, pp. 67-70, https://doi.org/10.25004/IJPSDR.2010.020115.
