ESTIMATION OF ARSENIC AND MERCURY IN A POLYHERBAL FORMULATION -SEPTILOC
Abstract
Herbal preparations are getting popular day by day as they are considered to be safe. Septiloc is also a herbal preparation which is useful in a wide range of wounds such as diabetic wounds, bed sores, ulcers, burns, post-surgical wounds etc. It was subjected to analysis by AAS-VGA for toxic heavy metals like arsenic and mercury. Levels of arsenic and mercury were estimated in ten different batches of Septiloc and evaluated with respect to permissible limit (PL) and provisional maximum tolerable daily intake (PMTDI). In most of the samples, As and Hg were either below the detection limit or below the PL and PMTDI. These results prove that Septiloc is a safe polyherbal preparation and is free from toxic effects of As and Hg.
Keywords:
Arsenic, Mercury, Septiloc, AAS-VGADOI
https://doi.org/10.25004/IJPSDR.2010.020117References
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3. Cabrera HN, Gomez Ml. Skin cancer induced by arsenic in water. J Cutan Med Surg 2003; 7: 106-111.
4. Vahidnia A, van der Voet GB, de Wolff FA. Arsenic neurotoxicity-A review. Human and Experimental Toxicology 2007; 26: 823-832.
5. Langford NJ, Ferner RE. Toxicity of mercury. Journal of Human Hypertension 1999; 13: 651–656.
6. ATSDR. Toxicological Profile for Mercury: Agency for Toxic Substances and Disease Registry, Atlanta, GA, 1999.
7. Sweet LI, Zelikoff JT. Toxicology and immunotoxicology of mercury: a comparative review in fish and humans. J Toxicol Environ Health B Crit rev 2001; 4: 161-205.
8. TCE. Mercury Poisoning in: The Columbia Encyclopedia, sixth edition, Colombian university Press, Columbia, 2008.
9. Celebi N, Canbay O, Aycan IO, Sahin A, Aypar U. Mercury intoxication and neuropathic pain. Paediatr Anaesth 2008; 18: 440-442.
10. Khan IA, Allgood J, Walker LA, Abourashed EA, Schlenk D, Benson WH. Determination of heavy metals and pesticides in ginseng products. Journal of AOAC 2001; 84: 936-939.
11. Chuang IC, Chen KS, Huang YL, Lee PN, Lin TH. Determination of trace elements in some natural drugs by atomic absorption spectrometry. Boil Trace Elem Res 2000; 76: 235-244.
12. Wen HM, Chen XH, Dong TX, Zhan HQ, Bi KS. Determination of heavy metals in four traditional Chinese medicines by ICP-MS. Zhongguo Zhong Yao Za Zhi 2006; 31: 1314-1317.
13. Rai V, Kakkar P, Singh J, Misra C, Kumar S, Mehrotra S. Toxic metals and organochlorine pesticides residue in single herbal drugs used in important ayurvedic formulation-Dashmoola. Environmental Monitoring Assessment 2008; 143: 273-277.
14. Ang HH, Lee KL. Evaluation of mercury contamination in Smilax myosotiflora herbal preparations. International Journal of Toxicology 2007; 26: 433-439.
15. Tay CH, Seah CS. Arsenic poisoning from anti-asthmatic herbal preparations. Med J Aust 1975; 2: 424-428.
16. FDA. U.S. Food and Drug Administration, U.S. Department of Health and Human Services, 21 CFR 556.60, 1999.
17. World Health organization. Evaluation of certain food additives and contaminants, Thirty-third report of the joint FAO/WHO expert committee on Food Additives. WHO Technical Report Series number 776. WHO, Geneva, Switzerland, 1989.
18. World Health Organization. Guideline for drinking water quality. Second edition, vol.1, Recommendations. WHO, Geneva, Switzerland, 1997.
19. World Health Organization. Quality control methods for medicinal plant materials. WHO, Geneva, Switzerland, 1998.
20. JECFA. Evaluation of certain food additives and contaminants. Forty-first report of the joint FAO/WHO expert committee on food additives, Geneva, Switzerland, 1993.
21. FDA. US Food and Drug Administration: Action Level for Methyl mercury in Fish, Federal Register 49, Nov. 19, 45663, 1984.
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01-01-2010
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“ESTIMATION OF ARSENIC AND MERCURY IN A POLYHERBAL FORMULATION -SEPTILOC”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 1, Jan. 2010, pp. 78-79, https://doi.org/10.25004/IJPSDR.2010.020117.
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Copyright (c) 2010 V. Naithani, N. Pathak, M. Chaudhary
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
“ESTIMATION OF ARSENIC AND MERCURY IN A POLYHERBAL FORMULATION -SEPTILOC”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 1, Jan. 2010, pp. 78-79, https://doi.org/10.25004/IJPSDR.2010.020117.
