Antioxidant Activity of Isolated Bioactive Compound from Mollugo nudicaulis
Abstract
Mollugo nudicaulis (M. nudicaulis), a medicinal plant with long history of use in traditional medicine. In the present study focused to explore the in vitro antioxidant potential of 12-(10-carboxydecanoyloxy)-12-oxododecanoic acid (compound-1) isolated and characterized as a specific natural compound from the aerial parts of M. nudicaulis. The results of these in vitro antioxidant assays were promising. Compound-1 demonstrated significant antioxidant activity when compared to the standard drug across all tests, effectively scavenging free radicals. These findings suggest that compound-1 from M. nudicaulis has considerable potential as a natural antioxidant. Its effectiveness indicates that it could be valuable in various applications within the pharmaceutical and food industries. The natural antioxidant properties of compound-1 could contribute to the development of new therapies and preservation methods, providing a natural alternative to synthetic antioxidants. However, to fully understand the potential of compound-1, further studies are necessary. These future investigations should aim to elucidate the precise mechanisms by which compound-1 exerts its antioxidant effects and explore its broader therapeutic applications. Overall, this study highlights the promising pharmacological potential of M. nudicaulis, particularly in the realm of natural antioxidants.
Keywords:
12-(10-carboxydecanoyloxy)-12-oxododecanoic acid, Mollugo nudicaulis, Antioxidant activity, Natural antioxidantDOI
https://doi.org/10.25004/IJPSDR.2024.160417References
Gatasheh MK, Natarajan SR, Krishnamoorthy R, Alsulami TS, Rajagopal P, Palanisamy CP, Veeraraghavan VP, Jayaraman S. Molecular analysis to identify novel potential biomarkers as drug targets in colorectal cancer therapy: an integrated bioinformatics analysis. Mol Cell Oncol. 2024; 11(1): 2326699. Available from: doi.org/10.1080/23723556.2024.2326699
Pei JJ, Deng W, Liu Y, Guo Y, Chen J, Abdu H, Khan MR, Palanisamy CP, El-Aty AM. A Comprehensive Review of Cornus officinalis: Health Benefits, Phytochemistry, and Pharmacological Effects for Functional Drug and Food Development. Front Nutr. 2023; 10: 1309963. Available from: doi.org/10.3389/fnut.2023.1309963
Alugoju P, Palanisamy CP, Anthikapalli NVA, Jayaraman S, Prasanskulab A, Chuchawankul S, Dyavaiah M, Tencomnao T. Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review. F1000Research. 2023; 12: 1265. Available from: doi.org/10.12688/f1000research.141669.1
Palanisamy CP, Poompradub S, Sansanaphongpricha K, Jayaraman S, Subramani K, Sonsudin F. Biosynthesis of silver nanoparticles (AgNPs) using ethanolic extract of Nigella sativa (L.) seeds promotes wound healing via PDGF and VEGF signalling pathways activation. Biocatal Agric Biotechnol. 2023; 54: 102970. Available from: doi.org/10.1016/j.bcab.2023.102970
Palanisamy CP, Phaniendra A, Jayaraman S, Poompradub S. Nigella sativa L. seed extracts promotes wound healing progress by activating VEGF and PDGF signalling pathways: An in vitro and in silico study. F1000 Research. 2023; 12: 436. Available from: doi.org/10.12688/f1000research.132106.2
Palanisamy CP, Sowmya S, Velmurugan D, Sivaraman T, Gopalakrishnan VK. Assessment of dual inhibitory activity of isolated natural compound (Epifriedelanol) from Cayratia trifolia (L.) against ovarian cancer. Bangladesh J Pharmacol. 2016; 11: 545-551. Available from: doi.org/10.3329/bjp.v11i2.24933
Pei JJ, Palanisamy CP, Phaniendra A, Venkata AAN, Natarajan PM, Umapathy VR, Swamikannu B, Jayaraman S, Rajagopal P, Poompradub S. A comprehensive review on bio-based materials for chronic diabetic wounds. Molecules. 2022; 28(2), 604. Available from: doi.org/10.3390/molecules28020604
Manimaran D, Elangovan N, Mani P, Subramanian K, Ali D, Alarifi S, Palanisamy CP, Zhang H, Rangasamy K, Palanisamy V, Mani R, Govarthanan K, Aruni W, Shanmugam R, Srinivasan GP, Kalirajan A. Isolongifolene-loaded chitosan nanoparticles synthesis and characterization for cancer treatment. Sci Rep. 2022; 12:19250. Available from: doi.org/10.1038/s41598-022-23386-4
Adeniran L, Palanisamy C, Ashafa A. Chemical profiling, in vitro antioxidant and antidiabetic assessment of flavonoids from the ethanol extract of Hermannia geniculata root. Sokoto J Vet Sci. 2021;19(1):1-13. Available from: doi.org/10.4314/sokjvs.v19i1.1
Raj SS, Panagal M. Bioactive Compound from Mollugo nudicaulis Lam. Promotes Wound Healing Activity: An In Silico and In Vitro Analysis. Biol Forum. 2023; 15(5): 389-398. Available from: doi.org/10.1072/bfaij-015--3982023-2
Palanisamy CP, Jh SF, Sekar R, Rajagopal P, Jeyaraman S. MTT assay based inhibition analysis of A2780 cells proliferation using Mollugo nudicaulis Lam. extract with CXCR4 and HER2 expression. Bioinformation. 2021;17(7):705. Available from: doi.org/10.6026/97320630017705
Raj SS, Panagal M. Preparation, Characterization and Cytotoxicity Evaluation of Starch-Based on Electrospun Nanofibrous Scaffold Incorporated with Bioactive Compound from Mollugo Nudicaulis. J Plant Sci Res. 2023; 39(3): 31-41. Available from: doi.org/10.32381/JPSR.2023.39.03.4
Blois MS. Antioxidant determinations by the use of a stable free radical. Nature. 1958;181(4617):1199-200. Available from: doi.org/10.1038/1811199a0
Pham HNT, Sakoff JA, Vuong Q Van, Bowyer MC, Scarlett CJ. Screening phytochemical content, antioxidant, antimicrobial and cytotoxic activities of Catharanthus roseus (L.) G. Don stem extract and its fractions. Biocatal Agric Biotechnol. 2018; 16: 405-411. Available from: doi.org/10.1016/j.bcab.2018.09.005
Elizabeth K, Rao MNA. Oxygen radical scavenging activity of curcumin. Int J Pharm. 1990; 58(3): 237-240. Available from: doi.org/10.1016/0378-5173(90)90201-E
Oyaizu M. Studies on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine. Jpn J Nutr Diet. 1986; 44(6): 307-315. Available from: doi.org/10.5264/eiyogakuzashi.44.307
Chakraborthy GS, Ghorpade PM. Free radical scavenging activity of Abutilon indicum (Linn) sweet stem extracts. Int J Chemtech Res. 2010; 2(1): 526-531. Available from: doi.org/10.54319/ijctr/140672
Palanisamy CP, Kanakasabapathy D, Ashafa AOT. In vitro antioxidant potential of Euclea crispa (Thunb.) leaf extracts. Pharmacog Res. 2018; 10(3): 296-300. Available from: doi.org/10.4103/pr.pr_123_17
Esmaeili A, Khakpoor M. Biological activities and chemical composition of solvent extracts of Stoechospermum marginatum (C. Agardh). Acta Biochim Pol. 2012; 59(4): 581-585. Available from: doi.org/10.1016/j.fct.2009.04.043
Ranković BR, Kosanić MM, Stanojković TP. Antioxidant, antimicrobial and anticancer activity of the lichens Cladonia furcata, Lecanora atra and Lecanora muralis. BMC Complement Med Ther. 2011; 11: 9. Available from: doi.org/10.1186/1472-6882-11-97
Gopalakrishnan V, Perumal P, Sowmya S, Pratibha P, Vidya B, Anusooriya P, Starlin T, Ravi S, Gopalakrishnan VK. Isolation, structural characterization and in silico drug-like properties prediction of a natural compound from the ethanolic extract of Cayratia trifolia (L.). Pharmacog Res. 2015; 7(1): 121-125. Available from: doi.org/10.4103/0974-8490.147226
Poornima K, Palanisamy CP, Gopalakrishnan VK. Protective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar Albino rats. BioMed Res Int. 2014; 2014: 1-9. Available from: doi.org/10.1155/2014/240243
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