Printing Health: Revolutionizing Pharmaceuticals through 3D Innovation
Abstract
The influence of additive manufacturing has grown significantly in the last few years because of the rising awareness and need for customized pharmaceuticals, medical instruments, and equipment. With the innovation in three-dimensional printing (3D-Printing) technology providing a broad scope to explore the infinite dimensions in the pharmaceuticals field, 3D items of diverse geometries may be created. Cost-effectiveness and on-demand printing are two significant advantages of printed drugs over traditional drug production, as is the ability to create very complicated and sophisticated dose forms based on individual needs. This article discusses a few 3D printing processes useful for producing pharmaceuticals as well as how they may be applied to creating effective pharmacological and therapeutical dosage forms, demonstrating the viability of this printing technology for routine industrial production processes.The two main pharmaceutical application areas were covered in this article. First, drug delivery systems, including different medications like controlled release solid dosage form, more than one drug in the form of polypills, gastro-floating mechanism of drug, in the form of Oro dispersible drug, and printed microneedles, are the subject that has received the most research. Second, 3D-Printing contributed to the creation of pharmaceutical tools including drug-eluting devices and tools to help chemists dispense medication.
Keywords:
3D Printing, Polypills, Additive Manufacturing, Drug-Delivery & MicroneedleDOI
https://doi.org/10.25004/IJPSDR.2024.160614References
Lim SH, Kathuria H, Tan JJ, Kang L. 3D printed drug delivery and testing systems—a passing fad or the future. Advanced drug delivery reviews. 2018 Jul 1; 132:139-68. Doi: 10.1016/j.addr.2018.05.006
Dumitrescu IB, Lupuliasa D, DRĂGOI C, NICOLAE AC, Pop A, ŢARAMET G, DRĂGĂNESCU D. The Age of Pharmaceutical 3D Printing. Technological and Therapeutical Implications of Additive Manufacturing. Farmacia. 2018 May 1;66(3). doi:10.31925/FARMACIA.2018.3.1
Goole J, Amighi K. 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems. International journal of pharmaceutics. 2016 Feb 29;499(1-2):376-94. doi.org/10.1016/j.ijpharm.2015.12.071
Alhnan MA, Okwuosa TC, Sadia M, Wan KW, Ahmed W, Arafat B. Emergence of 3D printed dosage forms: opportunities and challenges. Pharmaceutical research. 2016 Aug; 33:1817-32. doi.org/10.1007/s11095-016-1933-1
Drăgănescu DO, Lupuliasa D, Burcea Dragomiroiu GT, Roșca AC, Hincu L, Cioacă DA. 3D printing pharmaceutical formulation of drugs in personalized therapy. Farmacia. 2019 Jan 1;67(1):1-9. doi.org/10.31925/farmacia.2019.1.1
Zeeshan F, Madheswaran T, Pandey M, Gorain B. Three-dimensional (3-D) printing technology exploited for the fabrication of drug delivery systems. Current Pharmaceutical Design. 2018 Nov 1;24(42):5019-28. doi.org/10.2174/1381612825666190101111525
Alruwaili NK, Rizwanullah M, Abbas Bukhari SN, Amir M, Ahmed MM, Fazil M. 3D printing technology in design of pharmaceutical products. Current pharmaceutical design. 2018 Nov 1;24(42):5009-18. doi.org/10.2174/1381612825666190116104620
Narkevich IA, Flisyuk EV, Terent’eva OA, Semin AA. Additive manufacturing technologies for pharmaceutics. Pharmaceutical Chemistry Journal. 2018 Feb;51(11):1025-9. doi.org/10.1007/s11094-018-1733-5
Liang K, Brambilla D, Leroux JC. Is 3D printing of pharmaceuticals a disruptor or enabler. Advanced Materials. 2019 Feb;31(5):1805680. doi.org/10.1002/adma.201805680
Palekar S, Nukala PK, Mishra SM, Kipping T, Patel K. Application of 3D printing technology and quality by design approach for development of age-appropriate pediatric formulation of baclofen. International journal of pharmaceutics. 2019 Feb 10; 556:106-16. doi.org/10.1016/j.ijpharm.2018.11.062
Robles Martinez P, Basit AW, Gaisford S. The history, developments and opportunities of stereolithography. 3D Printing of Pharmaceuticals. 2018:55-79. doi.org/10.1007/978-3-319-90755-0_4
Aimar A, Palermo A, Innocenti B. The role of 3D printing in medical applications: a state of the art. Journal of healthcare engineering. 2019;2019(1):5340616. doi.org/10.1155/2019/5340616
Daly R, Harrington TS, Martin GD, Hutchings IM. Inkjet printing for pharmaceutics–a review of research and manufacturing. International journal of pharmaceutics. 2015 Oct 30;494(2):554-67. doi.org/10.1016/j.ijpharm.2015.03.017
Awad A, Trenfield SJ, Gaisford S, Basit AW. 3D printed medicines: A new branch of digital healthcare. International journal of pharmaceutics. 2018 Sep 5;548(1):586-96. doi.org/10.1016/j.ijpharm.2018.07.024
Osouli-Bostanabad K, Adibkia K. Made-on-demand, complex and personalized 3D-printed drug products. BioImpacts: BI. 2018;8(2):77. doi:10.15171/bi.2018.09.
Ahmad N, Gopinath P, Vinogradov A. 3D printing in medicine: Current challenges and potential applications. In3D Printing Technology in Nanomedicine 2019 (pp. 1-22). doi.org/10.1016/B978-0-12-815890-6.00001-3
Litman T. Personalized medicine—concepts, technologies, and applications in inflammatory skin diseases. Apmis. 2019 May;127(5):386-424. doi.org/10.1111/apm.12934
Prodan Žitnik I, Černe D, Mancini I, Simi L, Pazzagli M, Di Resta C, Podgornik H, Repič Lampret B, Trebušak Podkrajšek K, Sipeky C, Van Schaik R. Personalized laboratory medicine: a patient-centered future approach. Clinical Chemistry and Laboratory Medicine (CCLM). 2018 Nov 27;56(12):1981-91. doi.org/10.1515/cclm-2018-0181
Mathur S, Sutton J. Personalized medicine could transform healthcare. Biomedical reports. 2017 Jul 1;7(1): 3-5.doi.org/10.3892/br.2017.922
Raijada D, Wac K, Greisen E, Rantanen J, Genina N. Integration of personalized drug delivery systems into digital health. Advanced drug delivery reviews. 2021 Sep 1; 176:113857. doi.org/10.1016/j.addr.2021.113857
Goyanes A, Madla CM, Umerji A, Piñeiro GD, Montero JM, Diaz MJ, Barcia MG, Taherali F, Sánchez-Pintos P, Couce ML, Gaisford S. Automated therapy preparation of isoleucine formulations using 3D printing for the treatment of MSUD: First single-centre, prospective, crossover study in patients. International Journal of Pharmaceutics. 2019 Aug 15; 567:118497. doi.org/10.1016/j.ijpharm.2019.118497
Khaled SA, Burley JC, Alexander MR, Yang J, Roberts CJ. 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. Journal of controlled release. 2015 Nov 10; 217:308-14. doi.org/10.1016/j.jconrel.2015.09.028
Norman J, Madurawe RD, Moore CM, Khan MA, Khairuzzaman A. A new chapter in pharmaceutical manufacturing: 3D-printed drug products. Advanced drug delivery reviews. 2017 Jan 1; 108:39-50. doi.org/10.1016/j.addr.2016.03.001
Ervasti T, Simonaho SP, Ketolainen J, Forsberg P, Fransson M, Wikström H, Folestad S, Lakio S, Tajarobi P, Abrahmsén-Alami S. Continuous manufacturing of extended-release tablets via powder mixing and direct compression. International journal of pharmaceutics. 2015 Nov 10;495(1):290-301. doi.org/10.1016/j.ijpharm.2015.08.077
Lind J, Kälvemark Sporrong S, Kaae S, Rantanen J, Genina N. Social aspects in additive manufacturing of pharmaceutical products. Expert Opinion on Drug Delivery. 2017 Aug 3;14(8):927-36. doi.org/10.1080/17425247.2017.1266336
Konta AA, García-Piña M, Serrano DR. Personalized 3D printed medicines: which techniques and polymers are more successful. Bioengineering. 2017 Sep 22;4(4):79. doi.org/10.3390/bioengineering4040079
De Gans BJ, Duineveld PC, Schubert US. Inkjet printing of polymers: state of the art and future developments. Advanced materials. 2004 Feb 3;16(3):203-13.doi.org/10.1002/adma.200300385
Moulton SE, Wallace GG. 3-dimensional (3D) fabricated polymer-based drug delivery systems. Journal of Controlled Release. 2014 Nov 10; 193:27-34. doi.org/10.1016/j.jconrel.2014.07.005
Sumerel J, Lewis J, Doraiswamy A, Deravi LF, Sewell SL, Gerdon AE, Wright DW, Narayan RJ. Piezoelectric ink jet processing of materials for medicaland biological applications. Biotechnology Journal: Healthcare Nutrition Technology. 2006 Sep;1(9):976-87. doi.org/10.1002/biot.200600123
Gross BC, Erkal JL, Lockwood SY, Chen C, Spence DM. Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. doi.org/10.1021/ac403397r
Tofail SA, Koumoulos EP, Bandyopadhyay A, Bose S, O’Donoghue L, Charitidis C. Additive manufacturing: scientific and technological challenges, market uptake and opportunities. Materials today. 2018 Jan 1;21(1):22-37. doi.org/10.1016/j.mattod.2017.07.001
Vaezi M, Seitz H, Yang S. A review on 3D micro-additive manufacturing technologies. The International Journal of Advanced Manufacturing Technology. 2013 Jul; 67:1721-54. doi.org/10.1007/s00170-012-4605-2
Alhijjaj M, Belton P, Qi S. An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing. European Journal of Pharmaceutics and Biopharmaceutics. 2016 Nov 1; 108:111-25. doi.org/10.1016/j.ejpb.2016.08.016
Goyanes A, Martinez PR, Buanz A, Basit AW, Gaisford S. Effect of geometry on drug release from 3D printed tablets. International journal of pharmaceutics. 2015 Oct 30;494(2):657-63. doi.org/10.1016/j.ijpharm.2015.04.069
Vozzi G, Flaim C, Ahluwalia A, Bhatia S. Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. Biomaterials. 2003 Jun 1;24(14):2533-40. doi.org/10.1016/S0142-9612(03)00052-8
Tirella A, Vozzi F, Vozzi G, Ahluwalia A. PAM2 (piston assisted microsyringe): a new rapid prototyping technique for bio fabrication of cell incorporated scaffolds. Tissue Engineering Part C: Methods. 2011 Feb 1;17(2):229-37. doi.org/10.1089/ten.tec.2010.0195
Chia HN, Wu BM. Recent advances in 3D printing of biomaterials. Journal of biological engineering. 2015 Dec; 9:1-4. doi.org/10.1186/s13036-015-0001-4
Melchels FP, Feijen J, Grijpma DW. A review on stereolithography and its applications in biomedical engineering. Biomaterials. 2010 Aug 1;31(24):6121-30. doi.org/10.1016/j.biomaterials.2010.04.050
Won JY, Kim J, Gao G, Kim J, Jang J, Park YH, Cho DW. 3D printing of drug-loaded multi-shell rods for local delivery of bevacizumab and dexamethasone: A synergetic therapy for retinal vascular diseases. Acta Biomaterialia. 2020 Oct 15; 116:174-85. doi.org/10.1016/j.actbio.2020.09.015
Bikas H, Stavropoulos P, Chryssolouris G. Additive manufacturing methods and modelling approaches: a critical review. The International Journal of Advanced Manufacturing Technology. 2016 Mar; 83:389-405. doi.org/10.1007/s00170-015-7576-2
Bezuidenhout MB, Dimitrov DM, Van Staden AD, Oosthuizen GA, Dicks LM. Titanium‐Based Hip Stems with Drug Delivery Functionality through Additive Manufacturing. BioMed research international. 2015;2015(1):134093. doi.org/10.1155/2015/134093
Sen K, Manchanda A, Mehta T, Ma AW, Chaudhuri B. Formulation design for inkjet-based 3D printed tablets. International journal of pharmaceutics. 2020 Jun 30; 584:119430. doi.org/10.1016/j.ijpharm.2020.119430
Rahman Z, Barakh Ali SF, Ozkan T, Charoo NA, Reddy IK, Khan MA. Additive manufacturing with 3D printing: progress from bench to bedside. The AAPS journal. 2018 Nov; 20:1-4. doi.org/10.1208/s12248-018-0225-6
Park BJ, Choi HJ, Moon SJ, Kim SJ, Bajracharya R, Min JY, Han HK. Pharmaceutical applications of 3D printing technology: current understanding and future perspectives. Journal of Pharmaceutical Investigation. 2019 Nov; 49:575-85. doi.org/10.1007/s40005-018-00414-y
Tan DK, Maniruzzaman M, Nokhodchi A. Advanced pharmaceutical applications of hot-melt extrusion coupled with fused deposition modelling (FDM) 3D printing for personalised drug delivery. Pharmaceutics. 2018 Oct 24;10(4):203. doi.org/10.3390/pharmaceutics10040203
Park J, Kwon T, Kim J, Jin H, Kim HY, Kim B, Joo SH, Lee K. Hollow nanoparticles as emerging electrocatalysts for renewable energy conversion reactions. Chemical Society Reviews. 2018;47(22):8173-202. doi: 10.1039/C8CS00336J
Charoo NA, Barakh Ali SF, Mohamed EM, Kuttolamadom MA, Ozkan T, Khan MA, Rahman Z. Selective laser sintering 3D printing–an overview of the technology and pharmaceutical applications. Drug development and industrial pharmacy. 2020 Jun 2;46(6):869-77. doi.org/10.1080/03639045.2020.1764027
Sandler N, Salmela I, Fallarero A, Rosling A, Khajeheian M, Kolakovic R, Genina N, Nyman J, Vuorela P. Towards fabrication of 3D printed medical devices to prevent biofilm formation. International journal of pharmaceutics. 2014 Jan 1;459(1-2):62-4. doi.org/10.1016/j.ijpharm.2013.11.001
Genina N, Holländer J, Jukarainen H, Mäkilä E, Salonen J, Sandler N. Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices. European Journal of Pharmaceutical Sciences. 2016 Jul 30; 90:53-63. doi.org/10.1016/j.ejps.2015.11.005
Tappa K, Jammalamadaka U, Weisman JA, Ballard DH, Wolford DD, Pascual-Garrido C, Wolford LM, Woodard PK, Mills DK. 3D printing custom bioactive and absorbable surgical screws, pins, and bone plates for localized drug delivery. Journal of functional biomaterials. 2019 Apr 1;10(2):17. doi.org/10.3390/jfb10020017
Ballard DH, Weisman JA, Jammalamadaka U, Tappa K, Alexander JS, Griffen FD. Three-dimensional printing of bioactive hernia meshes: In vitro proof of principle. Surgery. 2017 Jun 1;161(6):1479-81. Doi: 10.1016/j.surg.2016.08.033
Water JJ, Bohr A, Boetker J, Aho J, Sandler N, Nielsen HM, Rantanen J. Three-dimensional printing of drug-eluting implants: preparation of an antimicrobial polylactide feedstock material. Journal of pharmaceutical sciences. 2015 Mar 1;104(3):1099-107. doi.org/10.1002/jps.24305
Weisman JA, Nicholson JC, Tappa K, Jammalamadaka U, Wilson CG, Mills DK. Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications. International journal of nanomedicine. 2015 Jan 9:357-70. doi.org/10.2147/IJN.S74811
Fu J, Yu X, Jin Y. 3D printing of vaginal rings with personalized shapes for controlled release of progesterone. International journal of pharmaceutics. 2018 Mar 25;539(1-2):75-82. doi.org/10.1016/j.ijpharm.2018.01.036
Mills D, Tappa K, Jammalamadaka U, Weisman J, Woerner J. The use of 3D printing in the fabrication of nasal stents. Inventions. 2017 Dec 23;3(1):1. doi.org/10.3390/inventions3010001
Mathew E, Domínguez-Robles J, Stewart SA, Mancuso E, O’Donnell K, Larraneta E, Lamprou DA. Fused deposition modeling as an effective tool for anti-infective dialysis catheter fabrication. ACS Biomaterials Science & Engineering. 2019 Sep 23;5(11):6300-10. doi.org/10.1021/acsbiomaterials.9b01185
Tappa K, Jammalamadaka U, Ballard DH, Bruno T, Israel MR, Vemula H, Meacham JM, Mills DK, Woodard PK, Weisman JA. Medication eluting devices for the field of OBGYN (MEDOBGYN): 3D printed biodegradable hormone eluting constructs, a proof-of-concept study. PLoS One. 2017 Aug 10;12(8): e0182929. doi.org/10.1371/journal.pone.0182929
Domínguez-Robles J, Mancinelli C, Mancuso E, García-Romero I, Gilmore BF, Casettari L, Larrañeta E, Lamprou DA. 3D printing of drug-loaded thermoplastic polyurethane meshes: A potential material for soft tissue reinforcement in vaginal surgery. Pharmaceutics. 2020 Jan 13;12(1):63. doi.org/10.3390/pharmaceutics12010063
Laronda MM, Rutz AL, Xiao S, Whelan KA, Duncan FE, Roth EW, Woodruff TK, Shah RN. A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice. Nat Commun 8: 15261. doi.org/10.1038/ncomms15261
Holländer J, Genina N, Jukarainen H, Khajeheian M, Rosling A, Mäkilä E, Sandler N. Three-dimensional printed PCL-based implantable prototypes of medical devices for controlled drug delivery. Journal of pharmaceutical sciences. 2016 Sep 1;105(9):2665-76. doi.org/10.1016/j.xphs.2015.12.012
Chou PY, Chou YC, Lai YH, Lin YT, Lu CJ, Liu SJ. Fabrication of drug-eluting nano-hydroxylapatite filled polycaprolactone nanocomposites using solution-extrusion 3D printing technique. Polymers. 2021 Jan 20;13(3):318. doi.org/10.3390/polym13030318
Yi HG, Choi YJ, Kang KS, Hong JM, Pati RG, Park MN, Shim IK, Lee CM, Kim SC, Cho DW. A 3D-printed local drug delivery patch for pancreatic cancer growth suppression. Journal of controlled release. 2016 Sep 28; 238:231-41. doi.org/10.1016/j.jconrel.2016.06.015
Qamar N, Abbas N, Irfan M, Hussain A, Arshad MS, Latif S, Mehmood F, Ghori MU. Personalized 3D printed ciprofloxacin impregnated meshes for the management of hernia. Journal of Drug Delivery Science and Technology. 2019 Oct 1; 53:101164. doi.org/10.1016/j.jddst.2019.101164
Mau R, Reske T, Eickner T, Grabow N, Seitz H. DLP 3D printing of Dexamethasone incorporated PEGDA-based photopolymers: compressive properties and drug release. Current Directions in Biomedical Engineering. 2020 Sep 1;6(3):406-9. doi.org/10.1515/cdbme-2020-3105
Yang Y, Zhou Y, Lin X, Yang Q, Yang G. Printability of external and internal structures based on digital light processing 3D printing technique. Pharmaceutics. 2020 Mar;12(3):207. doi.org/10.3390/pharmaceutics12030207
Huang W, Zheng Q, Sun W, Xu H, Yang X. Levofloxacin implants with predefined microstructure fabricated by three-dimensional printing technique. International journal of pharmaceutics. 2007 Jul 18;339(1-2):33-8. doi.org/10.1016/j.ijpharm.2007.02.021
Wu W, Zheng Q, Guo X, Sun J, Liu Y. A programmed release multi-drug implant fabricated by three-dimensional printing technology for bone tuberculosis therapy. Biomedical Materials. 2009 Nov 9;4(6):065005. Doi: 10.1088/1748-6041/4/6/065005
Wu W, Ye C, Zheng Q, Wu G, Cheng Z. A therapeutic delivery system for chronic osteomyelitis via a multi-drug implant based on three-dimensional printing technology. Journal of Biomaterials Applications. 2016 Aug;31(2):250-60. doi.org/10.1177/0885328216640660
Wu G, Wu W, Zheng Q, Li J, Zhou J, Hu Z. Experimental study of PLLA/INH slow-release implant fabricated by three-dimensional printing technique and drug release characteristics in vitro. Biomedical engineering online. 2014 Dec; 13:1-1. doi.org/10.1186/1475-925X-13-97
Li J, Hsu Y, Luo E, Khadka A, Hu J. Computer-aided design and manufacturing and rapid prototyped nanoscale hydroxyapatite/polyamide (n-HA/PA) construction for condylar defect caused by mandibular angle ostectomy. Aesthetic plastic surgery. 2011 Aug; 35:636-40.
doi.org/10.1007/s00266-010-9602-y
Inzana JA, Trombetta RP, Schwarz EM, Kates SL, Awad HA. 3D printed bioceramics for dual antibiotic delivery to treat implant-associated bone infection. European cells & materials. 2015; 30:232. Doi: 10.22203/ecm. v030a16
Vorndran E, Klammert U, Ewald A, Barralet JE, Gbureck U. Simultaneous immobilization of bioactives during 3D powder printing of bioceramic drug‐release matrices. Advanced Functional Materials. 2010 May 25;20(10):1585-91. doi.org/10.1002/adfm.200901759
Wu BM, Borland SW, Giordano RA, Cima LG, Sachs EM, Cima MJ. Solid free-form fabrication of drug delivery devices. Journal of Controlled Release. 1996 Jun 1;40(1-2):77-87. doi.org/10.1016/0168-3659(95)00173-5
Boyer CJ, Woerner JE, Galea C, Gatlin CA, Ghali GE, Mills DK, Weisman JA, McGee DJ, Alexander JS. Personalized bioactive nasal supports for postoperative cleft rhinoplasty. Journal of Oral and Maxillofacial Surgery. 2018 Jul 1;76(7):1562-e1. doi.org/10.1016/j.joms.2018.03.029
Poudel I, Annaji M, Arnold RD, Kaddoumi A, Shamsaei N, Lee S, Pegues J, Ahmadi Z, Samani MM, Corriveau K, Babu RJ. Dexamethasone eluting 3D printed metal devices for bone injuries. Therapeutic Delivery. 2020 Jun 1;11(6):373-86. doi.org/10.4155/tde-2020-0014
Maher S, Kaur G, Lima-Marques L, Evdokiou A, Losic D. Engineering of micro-to nanostructured 3D-printed drug-releasing titanium implants for enhanced osseointegration and localized delivery of anticancer drugs. ACS Applied Materials & Interfaces. 2017 Sep 6;9(35):29562-70. doi: 10.1021/acsami.7b09916
Visscher LE, Dang HP, Knackstedt MA, Hutmacher DW, Tran PA. 3D printed Polycaprolactone scaffolds with dual macro-microporosity for applications in local delivery of antibiotics. Materials science and engineering: C. 2018 Jun 1; 87:78-89. doi.org/10.1016/j.msec.2018.02.008
Calero Castro FJ, Yuste Y, Pereira S, Garvín MD, López García MÁ, Padillo FJ, de la Portilla F. Proof of concept, design, and manufacture via 3‐D printing of a mesh with bactericidal capacity: Behaviour in vitro and in vivo. Journal of Tissue Engineering and Regenerative Medicine. 2019 Nov;13(11):1955-64. doi.org/10.1002/term.2944
Zhao C, Wang Z, Hua C, Ji J, Zhou Z, Fang Y, Weng D, Lu L, Pang Y, Sun W. Design, modeling and 3D printing of a personalized cervix tissue implant with protein release function. Biomedical Materials. 2020 May 29;15(4):045005. doi: 10.1088/1748-605X/ab7b3b
Gbureck U, Vorndran E, Müller FA, Barralet JE. Low temperature direct 3D printed bioceramics and biocomposites as drug release matrices. Journal of Controlled Release. 2007 Sep 26;122(2):173-80. doi.org/10.1016/j.jconrel.2007.06.022
Wang Y, Sun L, Mei Z, Zhang F, He M, Fletcher C, Wang F, Yang J, Bi D, Jiang Y, Liu P. 3D printed biodegradable implants as an individualized drug delivery system for local chemotherapy of osteosarcoma. Materials & Design. 2020 Jan 15; 186:108336. doi.org/10.1016/j.matdes.2019.108336
Leong KF, Phua KK, Chua CK, Du ZH, Teo KO. Fabrication of porous polymeric matrix drug delivery devices using the selective laser sintering technique. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 2001 Feb 1;215(2):191-2. doi.org/10.1243/0954411011533751
Martin V, Ribeiro IA, Alves MM, Gonçalves L, Claudio RA, Grenho L, Fernandes MH, Gomes P, Santos CF, Bettencourt AF. Engineering a multifunctional 3D-printed PLA-collagen-minocycline-nanohydroxyapatite scaffold with combined antimicrobial and osteogenic effects for bone regeneration. Materials science and engineering: C. 2019 Aug 1; 101:15-26. doi.org/10.1016/j.msec.2019.03.056
Boyer CJ, Ballard DH, Weisman JA, Hurst S, McGee DJ, Mills DK, Woerner JE, Jammalamadaka U, Tappa K, Alexander JS. Three-dimensional printing antimicrobial and radiopaque constructs. 3D printing and additive manufacturing. 2018 Mar 1;5(1):29-36. doi.org/10.1089/3D-Printing.2017.0099
Zhao J, Xu X, Wang M, Wang L. A new model of a 3D-printed shell with convex drug release profile. Dissolute Technol. 2018 Feb 1;25(1):24-8. doi.org/10.14227/DT250118P24
Kadry H, Al-Hilal TA, Keshavarz A, Alam F, Xu C, Joy A, Ahsan F. Multi-purposely filaments of HPMC for 3D printing of medications with tailored drug release and timed-absorption. International journal of pharmaceutics. 2018 Jun 10;544(1):285-96. doi.org/10.1016/j.ijpharm.2018.04.010
Yang Y, Wang H, Li H, Ou Z, Yang G. 3D printed tablets with internal scaffold structure using ethyl cellulose to achieve sustained ibuprofen release. European Journal of Pharmaceutical Sciences. 2018 Mar 30;115:11-8. doi.org/10.1016/j.ejps.2018.01.005
Isreb A, Baj K, Wojsz M, Isreb M, Peak M, Alhnan MA. 3D printed oral theophylline doses with innovative ‘radiator-like’design: Impact of polyethylene oxide (PEO) molecular weight. International journal of pharmaceutics. 2019 Jun 10; 564:98-105. doi.org/10.1016/j.ijpharm.2019.04.017
Khaled SA, Burley JC, Alexander MR, Yang J, Roberts CJ. 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. Journal of controlled release. 2015 Nov 10; 217:308-14. doi.org/10.1016/j.jconrel.2015.09.028
Pereira BC, Isreb A, Forbes RT, Dores F, Habashy R, Petit JB, Alhnan MA, Oga EF. ‘Temporary Plasticiser’: A novel solution to fabricate 3D printed patient-centred cardiovascular ‘Polypill’architectures. European Journal of Pharmaceutics and Biopharmaceutics. 2019 Feb 1; 135:94-103. doi.org/10.1016/j.ejpb.2018.12.009
Li Q, Guan X, Cui M, Zhu Z, Chen K, Wen H, Jia D, Hou J, Xu W, Yang X, Pan W. Preparation and investigation of novel gastro-floating tablets with 3D extrusion-based printing. International journal of pharmaceutics. 2018 Jan 15;535(1-2):325-32. doi.org/10.1016/j.ijpharm.2017.10.037
Huanbutta K, Sangnim T. Design and development of zero-order drug release gastroprotective floating tablets fabricated by 3D printing technology. Journal of Drug Delivery Science and Technology. 2019 Aug 1; 52:831-7. doi.org/10.1016/j.jddst.2019.06.004
Wen H, He B, Wang H, Chen F, Li P, Cui M, Li Q, Pan W, Yang X. Structure-based gastro-retentive and controlled-release drug delivery with novel 3D printing. AAPS Pharm SciTech. 2019 Feb; 20:1-2. doi.org/10.1208/s12249-018-1237-3
Fina F, Goyanes A, Madla CM, Awad A, Trenfield SJ, Kuek JM, Patel P, Gaisford S, Basit AW. 3D printing of drug-loaded gyroid lattices using selective laser sintering. International journal of pharmaceutics. 2018 Aug 25;547(1-2):44-52. doi.org/10.1016/j.ijpharm.2018.05.044
Breitkreutz J, Boos J. Paediatric and geriatric drug delivery. Expert opinion on drug delivery. 2007 Jan 1;4(1):37-45. doi.org/10.1517/17425247.4.1.37
Scoutaris N, Ross SA, Douroumis D. 3D printed “Starmix” drug loaded dosage forms for paediatric applications. Pharmaceutical research. 2018 Feb; 35:1-1. doi.org/10.1007/s11095-017-2284-2
Chen G, Xu Y, Kwok PC, Kang L. Pharmaceutical applications of 3D printing. Additive Manufacturing. 2020 Aug 1; 34:101209. doi.org/10.1016/j.addma.2020.101209
Economidou SN, Pere CP, Reid A, Uddin MJ, Windmill JF, Lamprou DA, Douroumis D. 3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery. Materials Science and Engineering: C. 2019 Sep 1; 102:743-55. doi.org/10.1016/j.msec.2019.04.063
Ahlfeld T, Akkineni AR, Förster Y, Köhler T, Knaack S, Gelinsky M, Lode A. Design and fabrication of complex scaffolds for bone defect healing: combined 3D plotting of a calcium phosphate cement and a growth factor-loaded hydrogel. Annals of biomedical engineering. 2017 Jan; 45:224-36. doi.org/10.1007/s10439-016-1685-4
Uddin MJ, Scoutaris N, Economidou SN, Giraud C, Chowdhry BZ, Donnelly RF, Douroumis D. 3D printed microneedles for anticancer therapy of skin tumours. Materials Science and Engineering: C. 2020 Feb 1; 107:110248. doi.org/10.1016/j.msec.2019.110248
Xenikakis I, Tzimtzimis M, Tsongas K, Andreadis D, Demiri E, Tzetzis D, Fatouros DG. Fabrication and finite element analysis of stereolithographic 3D printed microneedles for transdermal delivery of model dyes across human skin in vitro. European Journal of Pharmaceutical Sciences. 2019 Sep 1; 137:104976. doi.org/10.1016/j.ejps.2019.104976
Niese S, Breitkreutz J, Quodbach J. Development of a dosing device for individualized dosing of orodispersible warfarin films. International Journal of Pharmaceutics. 2019 Apr 20; 561:314-23. doi.org/10.1016/j.ijpharm.2019.03.019
Verstraete G, Samaro A, Grymonpré W, Vanhoorne V, Van Snick B, Boone MN, Hellemans T, Van Hoorebeke L, Remon JP, Vervaet C. 3D printing of high drug loaded dosage forms using thermoplastic polyurethanes. International journal of pharmaceutics. 2018 Jan 30;536(1):318-25. doi.org/10.1016/j.ijpharm.2017.12.002
Khaled SA, Alexander MR, Wildman RD, Wallace MJ, Sharpe S, Yoo J, Roberts CJ. 3D extrusion printing of high drug loading immediate release paracetamol tablets. International journal of pharmaceutics. 2018 Mar 1;538(1-2):223-30. doi.org/10.1016/j.ijpharm.2018.01.024
Skowyra J, Pietrzak K, Alhnan MA. Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing. European Journal of Pharmaceutical Sciences. 2015 Feb 20; 68:11-7. doi.org/10.1016/j.ejps.2014.11.009
Wang CC, Tejwani MR, Roach WJ, Kay JL, Yoo J, Surprenant HL, Monkhouse DC, Pryor TJ. Development of near zero-order release dosage forms using three-dimensional printing (3-DP™) technology. Drug development and industrial pharmacy. 2006 Jan 1;32(3):367-76. doi.org/10.1080/03639040500519300
Yu DG, Branford-White C, Ma ZH, Zhu LM, Li XY, Yang XL. Novel drug delivery devices for providing linear release profiles fabricated by 3D-Printing. International journal of pharmaceutics. 2009 Mar 31;370(1-2):160-6. doi.org/10.1016/j.ijpharm.2008.12.008
Goyanes A, Fina F, Martorana A, Sedough D, Gaisford S, Basit AW. Development of modified release 3D printed tablets (printlets) with pharmaceutical excipients using additive manufacturing. International journal of pharmaceutics. 2017 Jul 15;527(1-2):21-30. doi.org/10.1016/j.ijpharm.2017.05.021
Li Q, Guan X, Cui M, Zhu Z, Chen K, Wen H, Jia D, Hou J, Xu W, Yang X, Pan W. Preparation and investigation of novel gastro-floating tablets with 3D extrusion-based printing. International journal of pharmaceutics. 2018 Jan 15;535(1-2):325-32. doi.org/10.1016/j.ijpharm.2017.10.037
Kyobula M, Adedeji A, Alexander MR, Saleh E, Wildman R, Ashcroft I, Gellert PR, Roberts CJ. 3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release. Journal of Controlled release. 2017 Sep 10; 261:207-15. doi.org/10.1016/j.jconrel.2017.06.025
Wang J, Goyanes A, Gaisford S, Basit AW. Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. International journal of pharmaceutics. 2016 Apr 30;503(1-2):207-12. doi.org/10.1016/j.ijpharm.2016.03.016
Clark EA, Alexander MR, Irvine DJ, Roberts CJ, Wallace MJ, Sharpe S, Yoo J, Hague RJ, Tuck CJ, Wildman RD. 3D printing of tablets using inkjet with UV photoinitiation. International Journal of Pharmaceutics. 2017 Aug 30;529(1-2):523-30. doi.org/10.1016/j.ijpharm.2017.06.085
Khaled SA, Burley JC, Alexander MR, Yang J, Roberts CJ. 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. Journal of controlled release. 2015 Nov 10; 217:308-14. doi.org/10.1016/j.jconrel.2015.09.028
Goyanes A, Wang J, Buanz A, Martínez-Pacheco R, Telford R, Gaisford S, Basit AW. 3D printing of medicines: engineering novel oral devices with unique design and drug release characteristics. Molecular pharmaceutics. 2015 Nov 2;12(11):4077-84. doi: 0.1021/acs.molpharmaceut.5b00510
Goyanes A, Chang H, Sedough D, Hatton GB, Wang J, Buanz A, Gaisford S, Basit AW. Fabrication of controlled-release budesonide tablets via desktop (FDM) 3D printing. International journal of pharmaceutics. 2015 Dec 30;496(2):414-20. doi.org/10.1016/j.ijpharm.2015.10.039
Lu Y, Mantha SN, Crowder DC, Chinchilla S, Shah KN, Yun YH, Wicker RB, Choi JW. Micro stereolithography and characterization of poly (propylene fumarate)-based drug-loaded microneedle arrays. Bio fabrication. 2015 Sep 30;7(4):045001. Doi: 10.1088/1758-5090/7/4/045001
Lim SH, Ng JY, Kang L. Three-dimensional printing of a microneedle array on personalized curved surfaces for dual-pronged treatment of trigger finger. Bio fabrication. 2017 Jan 10;9(1):015010. Doi: 10.1088/1758-5090/9/1/015010
Lim SH, Kathuria H, Tan JJ, Kang L. 3D printed drug delivery and testing systems—a passing fad or the future. Advanced drug delivery reviews. 2018 Jul 1; 132:139-68. doi.org/10.1016/j.addr.2018.05.006
Bloomquist CJ, Mecham MB, Paradzinsky MD, Janusziewicz R, Warner SB, Luft JC, Mecham SJ, Wang AZ, DeSimone JM. Controlling release from 3D printed medical devices using CLIP and drug-loaded liquid resins. Journal of Controlled Release. 2018 May 28; 278:9-23. doi.org/10.1016/j.jconrel.2018.03.026
Al-Kinani AA, Zidan G, Elsaid N, Seyfoddin A, Alani AW, Alany RG. Ophthalmic gels: Past, present and future. Advanced drug delivery reviews. 2018 Feb 15; 126:113-26. doi.org/10.1016/j.addr.2017.12.017
Lipp R. Novel drug delivery systems for steroidal hormones. Expert Opinion on Therapeutic Patents. 2001 Aug 1;11(8):1291-9. doi.org/10.1517/13543776.11.8.1291
Fu J, Yu X, Jin Y. 3D printing of vaginal rings with personalized shapes for controlled release of progesterone. International journal of pharmaceutics. 2018 Mar 25;539(1-2):75-82. doi.org/10.1016/j.ijpharm.2018.01.036
Genina N, Holländer J, Jukarainen H, Mäkilä E, Salonen J, Sandler N. Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices. European Journal of Pharmaceutical Sciences. 2016 Jul 30; 90:53-63. doi.org/10.1016/j.ejps.2015.11.005
Weisman JA, Ballard DH, Jammalamadaka U, Tappa K, Sumerel J, D'Agostino HB, Mills DK, Woodard PK. 3D printed antibiotic and chemotherapeutic eluting catheters for potential use in interventional radiology: in vitro proof of concept study. Academic radiology. 2019 Feb 1;26(2):270-4. doi.org/10.1016/j.acra.2018.03.022
Mathew E, Domínguez-Robles J, Stewart SA, Mancuso E, O’Donnell K, Larraneta E, Lamprou DA. Fused deposition modeling as an effective tool for anti-infective dialysis catheter fabrication. ACS Biomaterials Science & Engineering. 2019 Sep 23;5(11):6300-10. Doi: 10.1021/acsbiomaterials.9b01185
Sandler N, Salmela I, Fallarero A, Rosling A, Khajeheian M, Kolakovic R, Genina N, Nyman J, Vuorela P. Towards fabrication of 3D printed medical devices to prevent biofilm formation. International journal of pharmaceutics. 2014 Jan 1;459(1-2):62-4. doi.org/10.1016/j.ijpharm.2013.11.001
Yang N, Chen H, Han H, Shen Y, Gu S, He Y, Guo S. 3D printing and coating to fabricate a hollow bullet-shaped implant with porous surface for controlled cytoxan release. International journal of pharmaceutics. 2018 Dec 1;552(1-2):91-8. doi.org/10.1016/j.ijpharm.2018.09.042
Ballard DH, Jammalamadaka U, Tappa K, Weisman JA, Boyer CJ, Alexander JS, Woodard PK. 3D printing of surgical hernia meshes impregnated with contrast agents: in vitro proof of concept with imaging characteristics on computed tomography. 3D Printing in Medicine. 2018 Dec; 4:1-6. doi.org/10.1186/s41205-018-0037-4
Holländer J, Hakala R, Suominen J, Moritz N, Yliruusi J, Sandler N. 3D printed UV light cured polydimethylsiloxane devices for drug delivery. International journal of pharmaceutics. 2018 Jun 15;544(2):433-42. doi.org/10.1016/j.ijpharm.2017.11.016
Kempin W, Franz C, Koster LC, Schneider F, Bogdahn M, Weitschies W, Seidlitz A. Assessment of different polymers and drug loads for fused deposition modeling of drug loaded implants. European Journal of Pharmaceutics and Biopharmaceutics. 2017 Jun 1; 115:84-93. doi.org/10.1016/j.ejpb.2017.02.014
Arany P, Papp I, Zichar M, Csontos M, Elek J, Regdon Jr G, Budai I, Béres M, Gesztelyi R, Fehér P, Ujhelyi Z. In vitro tests of FDM 3D-printed diclofenac sodium-containing implants. Molecules. 2020 Dec 13;25(24):5889. doi.org/10.3390/molecules25245889
Stewart SA, Domínguez-Robles J, McIlorum VJ, Mancuso E, Lamprou DA, Donnelly RF, Larrañeta E. Development of a biodegradable subcutaneous implant for prolonged drug delivery using 3D printing. Pharmaceutics. 2020 Jan 28;12(2):105. doi.org/10.3390/pharmaceutics12020105
Trombetta, R.P., Ninomiya, M.J., El-Atawneh, I.M., Knapp, E.K., de Mesy Bentley, K.L., Dunman, P.M., Schwarz, E.M., Kates, S.L. and Awad, H.A., 2019. Calcium phosphate spacers for the local delivery of sitafloxacin and rifampin to treat orthopedic infections: efficacy and proof of concept in a mouse model of single-stage revision of device-associated osteomyelitis. Pharmaceutics, 11(2), p.94. doi.org/10.3390/pharmaceutics11020094
Lee JH, Baik JM, Yu YS, Kim JH, Ahn CB, Son KH, Kim JH, Choi ES, Lee JW. Development of a heat labile antibiotic eluting 3D printed scaffold for the treatment of osteomyelitis. Scientific reports. 2020 May 5;10(1):7554. doi.org/10.1038/s41598-020-64573-5
Amekyeh H, Tarlochan F, Billa N. Practicality of 3D printed personalized medicines in therapeutics. Frontiers in Pharmacology. 2021 Apr 12; 12:646836. doi.org/10.3389/fphar.2021.646836
Kassem T, Sarkar T, Nguyen T, Saha D, Ahsan F. 3D printing in solid dosage forms and organ-on-chip applications. Biosensors. 2022 Mar 22;12(4):186. doi.org/10.3390/bios12040186
Naresh V, Lee N. A review on biosensors and recent development of nanostructured materials-enabled biosensors. Sensors. 2021 Feb 5;21(4):1109. doi.org/10.3390/s21041109
Domsta V, Seidlitz A. 3D-printing of drug-eluting implants: an overview of the current developments described in the literature. Molecules. 2021 Jul 2;26(13):4066. doi.org/10.3390/molecules26134066
Morrison RJ, Kashlan KN, Flanangan CL, Wright JK, Green GE, Hollister SJ, Weatherwax KJ. Regulatory considerations in the design and manufacturing of implantable 3D‐printed medical devices. Clinical and translational science. 2015 Oct;8(5):594-600. doi.org/10.1111/cts.12315
Reddy CV, Venkatesh MP, Kumar P. First FDA approved 3D printed drug paved new path for increased precision in patient care. Applied Clinical Research, Clinical Trials and Regulatory Affairs. 2020 Aug 1;7(2):93-103. doi.org/10.2174/2213476X07666191226145027
Ricles LM, Coburn JC, Di Prima M, Oh SS. Regulating 3D-printed medical products. Science translational medicine. 2018 Oct 3;10(461): eaan6521. Doi: 10.1126/scitranslmed. aan65
Di Prima M, Coburn J, Hwang D, Kelly J, Khairuzzaman A, Ricles L. Additively manufactured medical products–the FDA perspective. 3D printing in medicine. 2016 Dec; 2:1-6. doi.org/10.1186/s41205-016-0005-9
Horst A, McDonald F. Uncertain but not unregulated: medical product regulation in the light of three-dimensional printed medical products. 3D Printing and Additive Manufacturing. 2020 Oct 1;7(5):248-57. doi.org/10.1089/3D-Printing.2020.007
Cardoso PH, Araújo ES. An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production of Drug Delivery Systems. Compounds. 2024 Jan 17;4(1):71-105. doi.org/10.3390/compounds4010004
Mirza M, Iqbal Z. 3D printing in pharmaceuticals: Regulatory perspective. Current Pharmaceutical Design. 2018 Nov 1;24(42):5081-3. doi.org/10.2174/1381612825666181130163027
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