SUB-ACUTE TOXICITY STUDIES OF PARACETAMOL INFUSION IN ALBINO WISTAR RATS
Abstract
The objective of the present study was to evaluate the sub-acute toxicity of paracetamol infusion in albino wistar rats (male and female) at different dose levels, ranging from 16 to 66 mg/kg body weight. No mortality was seen in any of the treatment groups during the course of study. Various physiological, hematological as well as biochemical parameters were studied and found not to be changed significantly, indicating that paracetamol infusion is non toxic even at higher dose level in wistar rats. Overall safety and tolerability profile of paracetamol infusion is proved good and does not appear to carry risk of serious adverse effects.
Keywords:
Paracetamol, toxicity, rat, biochemical parametersDOI
https://doi.org/10.25004/IJPSDR.2010.020212References
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18. Rumack BH, Matthew H. Acetaminophen Poisoning And Toxicity. Pediatrics. 1975; 55: 871-6.
19. Hart SG, Beierschmitt WP, Wyand DS, Khairallah EA, Cohen SD. Acetaminophen Nephrotoxicity in CD-1 Mice. I. Evidence of a Role for In situ Activation in Selective Covalent Binding and Toxicity. Toxicol Appl Pharmacol. 1994; 126:267-75.
20. Blakely P, McDonald BR. Acute Renal Failure Due To Acetaminophen Ingestion: A Case Report and Review of the Literature. J Am Soc Nephrol. 1995; 6:48-53.
21. Mitchell JR, McMurtry RJ, Statham CN, Nelson SD. Molecular Basis for Several Drug-Induced Nephropathies. Am J Med. 1977; 62: 518-26.
22. McMurtry RJ, Snodgrass WR, Mitchell JR. Renal Necrosis, Glutathione Depletion, and Covalent Binding after Acetaminophen. Toxicol Appl Pharmacol. 1978; 46: 87-100.
2. Graham GG, Robins S-A, Bryant KJ, et al. Inhibition of Prostaglandin Synthesis in Intact Cells by Paracetamol (Acetaminophen). Inflammopharmacol. 2001; 9: 131-42.
3. Piquet V, Desmeules J, Dayer P. Lack of Acetaminophen Ceiling Effect on R-III Nociceptive Fexion Reflex. Eur J Clin Pharmacol. 1998; 53: 321-324.
4. Chandrasekharan NV et al. COX-3, A Cyclooxygenase-1 Variant Inhibited By Acetaminophen And Other Analgesic/Antipyretic Drugs: Cloning, Structure, And Expression, Proc Natl Acad Sci. 2002; 99: 13926-13931.
5. Flower RJ, Vane JR, Inhibition of Prostaglandin Synthetase In Brain Explains The Anti-pyretic Activity Of Paracetamol (4-Acetamidophenol). Nature. 1972; 240: 410-411.
6. Piletta P, Porchet HC, Dayer P. Central Analgesic Effect of Acetaminophen but Not Of Aspirin. Clin Pharmacol Ther. 1991; 49: 350-354.
7. Romsing J, Moiniche S, Dahl JB. Rectal and Parenteral Paracetamol, And Paracetamol In Combination With NSAIDs, For Postoperative Analgesia. British J Anaest. 2002; 88: 215-226.
8. Benjamin N, Rawlins M, Vale JA. Drug Therapy and Poisoning. 5th ed. United Kingdom: WB Saunders, 2002, pp. 985-7.
9. Pajoumand A, Jalali N, Abdollahi M, Shadnia S. Successful Treatment of Acetaminophen Overdose Associated With Hepatic Failure. Hum Exp Toxicol. 2003; 22: 453-8.
10. Rumack BH, Matthew H. Acetaminophen Poisoning And Toxicity. Pediatrics. 1975; 55: 871-6.
11. Walker RM, Massey TE, McElligott TF, Racz WJ. Acetaminophen-Induced Hypothermia, Hepatic Congestion, And Modification By N-acetylcysteine In Mice. Toxicol App. Pharmacol. 1981; 59: 500–507.
12. Blakely P, McDonald BR. Acute Renal Failure Due to Acetaminophen Ingestion: A Case Report and Review of the Literature. J Am Soc Nephrol 1995; 6: 48-53.
13. McJunkin B, Barwick KW, Little WC, Winfield JB. Fatal Massive Hepatic Necrosis Following Acetaminophen Overdose. JAMA. 1976; 236:1874-5.
14. Holmer PP, Owall A, Jakobsson J. Early Bioavailablity of Paracetamol after Oral or Intravenous Administration. Acta Anaesthesiol Scand. 2004; 48: 867-870.
15. Anderson BJ, Pons G, Autret-leca E, Allegaeart K, Boccard E. Pediatric Intravenous Paracetamol (Propacetamol) Pharmacokinetics: A Population Analysis. Ped Anesth. 2005; 15: 282-292.
16. Mossa JS, Tariq M, Mohsin A, Aqeel AM, Al-Yahya MA, Al-Said MS, et al. Pharmacological Studies On Aerial Parts Of Calotropis Procera. Am J Chin Med. 1991; 19: 223-231.
17. Mascolo N, Sharma R, Jain SC, Capasso F. Ethnopharmacology of Calotropis Procera Flowers. J Ethnopharmacol. 1998; 22: 211.
18. Rumack BH, Matthew H. Acetaminophen Poisoning And Toxicity. Pediatrics. 1975; 55: 871-6.
19. Hart SG, Beierschmitt WP, Wyand DS, Khairallah EA, Cohen SD. Acetaminophen Nephrotoxicity in CD-1 Mice. I. Evidence of a Role for In situ Activation in Selective Covalent Binding and Toxicity. Toxicol Appl Pharmacol. 1994; 126:267-75.
20. Blakely P, McDonald BR. Acute Renal Failure Due To Acetaminophen Ingestion: A Case Report and Review of the Literature. J Am Soc Nephrol. 1995; 6:48-53.
21. Mitchell JR, McMurtry RJ, Statham CN, Nelson SD. Molecular Basis for Several Drug-Induced Nephropathies. Am J Med. 1977; 62: 518-26.
22. McMurtry RJ, Snodgrass WR, Mitchell JR. Renal Necrosis, Glutathione Depletion, and Covalent Binding after Acetaminophen. Toxicol Appl Pharmacol. 1978; 46: 87-100.
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01-04-2010
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“SUB-ACUTE TOXICITY STUDIES OF PARACETAMOL INFUSION IN ALBINO WISTAR RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 2, Apr. 2010, pp. 142-5, https://doi.org/10.25004/IJPSDR.2010.020212.
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Copyright (c) 2010 Anurag Payasi, Manu Chaudhary, Brij Mohan Singh, Ankush Gupta, Rajesh Sehgal
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
“SUB-ACUTE TOXICITY STUDIES OF PARACETAMOL INFUSION IN ALBINO WISTAR RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 2, Apr. 2010, pp. 142-5, https://doi.org/10.25004/IJPSDR.2010.020212.
