SUB-ACUTE TOXICITY STUDY OF ETIMICIN SULPHATE IN WISTAR RAT
Abstract
The aim of the present study was to evaluate subacute toxicity of etimicin sulphate on wistar rat. Results from the present study have elucidated that treatment of etimicin sulphate exerts no significant signs of toxicity at any dose level used in the study. Physical, biochemical as well as hematological parameters was unaltered throughout the study. Histopathology of all organs confirmed no significant alteration at any dose levels. The results of study have suggested there was no obvious toxicity observed with the treatment of etimicin sulphate. It was found to be safe alternative for various severe infections.
Keywords:
Toxicity, Rat, Blood, Etimicin sulphateDOI
https://doi.org/10.25004/IJPSDR.2010.020207References
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15. Walker RJ, Duggin GG. Drug Nephrotoxicity. Annu Rev Pharmacol Toxicol. 1988; 28:331-345.
16. Lortholary O, Tod M, Cohen Y, Petitjean O. Aminoglycosides. Med Clin North Am 1995; 79:761-87.
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18. Vandewalle A, Farman N, Morin JP, Fillastre JP, Hatt PY, Bonvalet JP. Gentamicin Incorporation along the Nephron: Autoradiographic Study on Isolated Tubules. Kidney Int. 1981; 19:529-539
19. Friedman, SE, Grendell JH, McQuaid KR. Current Diagnosis and Treatment: In Gastroenterology. Lang Medical Books/McGraw-Hill New York, 2003; 664–679.
2. Sandhu JS, Sehgal A, Gupta O, Singh A. Aminoglycoside Nephrotoxicity Revisited. JIACM. 2007; 8: 331-3.
3. Kahlmeter G, Dahlager JI. Aminoglycoside Toxicity: a Review of Clinical Studies Published Between 1975 and 1982. J Antimicrob. Chemother. 1984; 13: 9-12.
4. Jia-Tai LI, Zhang Ye Liu, et al. The New Aminoglycoside Antibiotics in Vitro Anti-card Star Ototoxicity Comparison [J]. Chinese J Antibiot. 1995; 20: 442.
5. Xiao Hua D. Sulfuric Acid Etimicin Clinical Application and Safety Evaluation [J]. Chinese J Clin Pharm. 2004; 13: 320.
6. Chun-Lan T, Hu JL, Yang P et al. Etimicin and Netilmicin In Treatment of Lower Respiratory tract Bacterial Infections In The Clinical Efficacy And Safety Comparison [J]. Chinese Med Clin J. 2004; 23: 83
7. Martínez-Salgado C, López-Hernández FJ, López-Novoa JM. Glomerular Nephrotoxicity of Aminoglycosides. Toxicol App Pharmacol 2007; 223: 86-98.
8. Caiyun Z, Hou LT et al. Etimicin and Netilmicin in the Treatment of Bacterial Infections Evaluation [J]. Chinese J Hospital Pharm. 2003; 23: 288.
9. Sundin DP, Sandoval R, Molitoris BA. Gentamicin Inhibits Renal Protein And Phospholipid Metabolism In Rats: Implications Involving Intracellular Trafficking. J Am Soc Nephr. 2001; 12: 114-123.
10. Wang HX, Zhang LR, Ma XC, Ma TX. Influence of Piperacillin on Pharmacokinetics of Etimicin in Healthy Volunteers. Acta pharmacol Sinica 2002; 23:376-80.
11. Wang PY, Li X. and Fang YY et al. Ototoxicity of Antibiotic 89-07 and Netilmicin in Guinea. Chin J Anti. 1995; 20:448-454.
12. Bailey TC, Little JR, Littenberg B, Reichley RM, Dunagan WC. A Meta-analysis Of Extended-Interval Dosing Versus Multiple Daily Dosing of Aminoglycosides. Clin Infect Dis. 1997; 24:786-95.
13. Hatala R, Dinh TT, Cook DJ. Single Daily Dosing Of Aminoglycosides In Immunocompromised Adults: A System Rev. Clin Infect Dis. 1997; 24:810-815.
14. Freeman CD, Strayer AH. Mega-analysis Of Meta-analysis: An Examination of Meta-analysis With an Emphasis on Once Daily Aminoglycoside Comparative Trials. Pharmacother. 1996; 16:1093-102.
15. Walker RJ, Duggin GG. Drug Nephrotoxicity. Annu Rev Pharmacol Toxicol. 1988; 28:331-345.
16. Lortholary O, Tod M, Cohen Y, Petitjean O. Aminoglycosides. Med Clin North Am 1995; 79:761-87.
17. Kelvin H-V Tan, Mulheran M, Knox AJ, Smyth AR. Aminoglycoside Prescribing and Surveillance in Cystic Fibrosis. Am J Res Critl Care Med. 2003; 167: 819-823.
18. Vandewalle A, Farman N, Morin JP, Fillastre JP, Hatt PY, Bonvalet JP. Gentamicin Incorporation along the Nephron: Autoradiographic Study on Isolated Tubules. Kidney Int. 1981; 19:529-539
19. Friedman, SE, Grendell JH, McQuaid KR. Current Diagnosis and Treatment: In Gastroenterology. Lang Medical Books/McGraw-Hill New York, 2003; 664–679.
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01-04-2010
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“SUB-ACUTE TOXICITY STUDY OF ETIMICIN SULPHATE IN WISTAR RAT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 2, Apr. 2010, pp. 120-2, https://doi.org/10.25004/IJPSDR.2010.020207.
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Copyright (c) 2010 Anurag Payasi, Manu Chaudhary, Anupama Tamta, Vivek K. Dwivedi
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
“SUB-ACUTE TOXICITY STUDY OF ETIMICIN SULPHATE IN WISTAR RAT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 2, Apr. 2010, pp. 120-2, https://doi.org/10.25004/IJPSDR.2010.020207.
