SYNTHESIS AND ANTI-ULCER ACTIVITY OF SOME DIHYDROPYRIMIDINES

Authors

  • Kulbhushan Rana Department of Chemistry, S. D. College, Barnala, Punjab, India
  • Balbir Kaur Department of Chemistry, Punjabi University, Patiala
  • Gagandeep Chaudhary Department of Pharmacology, S. D. College of Pharmacy, Barnala, Punjab, India
  • Suresh Kumar Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala
  • Sandeep Goyal Department of Pharmacology, S. D. College of Pharmacy, Barnala, Punjab, India

Abstract

Wide range of biological activities is associated with 1, 4-dihydropyridines/ pyrimidines, individually or in combination. In view of this, synthesis of various 6-methyl-4-substitutedphenyl-2-thioxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylic acid ethyl esters and 6-methyl-4-substituted phenyl-2-S-alkyl(benzyl)-1, 4-dihydropyrimidine-5-carboxylic acid ethyl esters were undertaken for synthesizing biologically active molecules with improved activity, lesser toxicity with undesirable side effects in clinical use. All the synthesized compounds have been characterized by using IR, Mass studies, 1H NMR and elemental analysis. Further, some compounds were screened for anti-ulcer activity. Compound 4(r) has shown maximum anti-ulcer activity as compared to control group.

Keywords:

Anti-ulcer Activity, Dihydropyrimidines, Thioethers, tetrahydropyrimidines.

DOI

https://doi.org/10.25004/IJPSDR.2011.030313

References

1. Folkers K, Harwood H, Johanson T. Synthesis of 2-keto-1, 2, 3, 4,-tetrahydropyrmidines. 1932; 54: 3751-3758.
2. Singh K, Swanson B, Moreland S. Dihydropyrimidine angiotensin II receptor antagonists. J. Med. Chem. 1992; 35:4751-4763.
3. Singh K, Swanson B, Moreland S. Dihydropyrimidine calcium channel blockers as orally effective antihypertensive agents. J. Med. Chem. 1991; 34: 806-811.
4. Rovnyak G, Kimbal D, Beyer B, Hedberg D. Conformational and structural determinants of dihydropyrmidine calcium channel modulators. J. Med. Chem. 1995; 38: 119-129.
5. Lanjewar K, Rahatgaonkar A, Chorghade M, Saraf B. Synthesis and antimicrobial activity of some dihydropyrimidines. Ind. J. Chem. 2009; 48 B: 1732-1737.
6. Rana K, Kaur B, Kumar B. Synthesis and anti-hypertensive activity of some dihydropyrimidines. Ind. J. Chem. 2004; 43 B: 1553-1557.
7. Subudhi BB, Panda PK, Batta D. Synthesis and antiulcer study of 1, 4-dihydropyrimidines. Ind. J. Chem. 2009; 48 B: 725-728.
8. Patil A, Ganguly S, Surana S. Synthesis and antiulcer activity of 2-(5-substituted-1-H-benzomidazol-2-sulphiny-3-substituted quinazoline-4-one. J. Chem. Sci. 2010; 122: 443- 450.
9. Kappe CO, Kumar D, Varma RS. Microwave-assisted high-speed parallel synthesis of 4-Aryl-3, 4-dihydropyrimidin-2(1H)-ones using a solventless Biginelli condensation protocol. Synth. 1999; 10: 1799-1803.

Published

01-07-2011
Statistics
Abstract Display: 240
PDF Downloads: 343
Dimension Badge

How to Cite

“SYNTHESIS AND ANTI-ULCER ACTIVITY OF SOME DIHYDROPYRIMIDINES”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 3, July 2011, pp. 226-9, https://doi.org/10.25004/IJPSDR.2011.030313.

Issue

Volume 3, Issue 3, 2011

Section

Research Article

How to Cite

“SYNTHESIS AND ANTI-ULCER ACTIVITY OF SOME DIHYDROPYRIMIDINES”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 3, July 2011, pp. 226-9, https://doi.org/10.25004/IJPSDR.2011.030313.

Most read articles by the same author(s)