IN SILICO ADME AND TOXICITY STUDY OF SOME SELECTED ANTINEOPLASTIC DRUGS
Abstract
Cancer is a serious health problem that recognized as a group of diseases involving uncontrolled cell growth. Majority of cancer chemotherapeutic agents have serious toxicity profile. Due to this use of these agents are limited. Therefore, it is essential requirement for developing new chemotherapeutic agents to devoid toxicity. In this research work, we study the pharmacokinetic, toxicity and bioactivity profile of few selected chemotherapeutic agents by In silico method. These research investigations provide the lead for the development of new cancer chemotherapeutic agents with lesser toxicity and more effectiveness.
Keywords:
TPSA (Topological Polar Surface Area), anticancer, in silico toxicity, GPCR ligand, ion channel modulator, kinase inhibitor, nuclear receptor ligand, protease inhibitor, enzyme inhibitorDOI
https://doi.org/10.25004/IJPSDR.2016.080110References
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2. Tripathi KD. Essentials of medical pharmacology. JP Medical Ltd. (2013).
3. Lipinski CA. Lead-and drug-like compounds: the rule-of-five revolution. Drug Discovery Today: Technologies. 2004; 1(4): 337-341.
4. Srimai V, Ramesh M, Parameshwar KS, Parthasarathy T. Computer-aided design of selective Cytochrome P450 inhibitors and docking studies of alkyl resorcinol derivatives. Medicinal Chemistry Research. 2013; 22(11):5314-5323.
5. Abraham DJ. Burger's medicinal chemistry and drug discovery. Wiley Interscience, 2003.
6. Palm K, Stenberg P, Luthman, K, Artursson P. Polar molecular surface properties predict the intestinal absorption of drugs in humans. Pharmaceutical research. 1997; 14(5):568-571.
7. Sharma CS, Verma T, Singh HP, Kumar N. Synthesis, characterization and preliminary anticonvulsant evaluation of some flavanone incorporated semicarbazides. Medicinal Chemistry Research 2014; 23(11):4814-4824.
8. Verma A. Lead finding from Phyllanthus debelis with hepatoprotective potentials. Asian Pacific Journal of Tropical Biomedicine. 2012; 2(3): S1735-S1737.
Published
01-01-2016
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“IN SILICO ADME AND TOXICITY STUDY OF SOME SELECTED ANTINEOPLASTIC DRUGS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 8, no. 1, Jan. 2016, pp. 65-67, https://doi.org/10.25004/IJPSDR.2016.080110.
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How to Cite
“IN SILICO ADME AND TOXICITY STUDY OF SOME SELECTED ANTINEOPLASTIC DRUGS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 8, no. 1, Jan. 2016, pp. 65-67, https://doi.org/10.25004/IJPSDR.2016.080110.
