IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY STUDY OF SOME SELECTED ANTI-ASTHMATIC AGENTS
Abstract
Asthma is a disease affecting the airways that carry air to and from lungs. Exposure to various irritants and substances that trigger allergies (allergens) can trigger signs and symptoms of asthma. The prevalence of asthma varies widely in different regions of the world due to distinct genetic, environmental and occupational risk factors. In this research investigation, we study the pharmacokinetic, drug-likeness, bioactivity profile and toxicity profile of some selected anti-asthmatic agents by computational methods. The study provides the information about the pharmacokinetic and toxicity of existing drugs that can be used for design and development of new anti-asthmatic agents with more potency and lesser toxicity.
Keywords:
QSAR, TPSA, GPCR, Teratogenicity, GERD.DOI
https://doi.org/10.25004/IJPSDR.2018.100411References
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3. Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, Williams H, ISAAC Phase Three Study Group. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. The Lancet. 2006 Aug 26; 368(9537):733-43.
4. National Asthma Education, Prevention Program (National Heart, Lung, Blood Institute). Second Expert Panel on the Management of Asthma. Expert panel report 2: Guidelines for the diagnosis and management of asthma. DIANE Publishing; 1997.
5. O'Byrne PM, Cook D. Is nedocromil sodium effective treatment for asthma. European Respiratory Journal. 1993 Jan 1; 6(1):5-6.
6. Sharma CS, Mishra SS, Singh HP, Kumar N. In silico ADME and Toxicity Study of Some Selected Antineoplastic Drugs. International Journal of Pharmaceutical Sciences and Drug Research. 2016; 8(1):65-7.
7. Singh HP, Sharma CS, Mishra SS, Pandiya H, Kumar N. In silico ADME, Bioactivity and Toxicity Prediction of Some Selected Anti-Parkinson Agents. International Journal of Pharmaceutical and Phytopharmacological Research. 2017 Apr 17; 6(3):64-7.
8. Kumar N, Mishra SS, Sharma CS, Singh HP, Pandiya H. In silico Pharmacokinetic, Bioactivity and Toxicity Evaluation of Some Selected Anti-Ulcer Agents. International Journal of Pharmaceutical Sciences and Drug Research. 2017; 9(2):68-71.
9. Mishra SS, Sharma CS, Singh HP, Pandiya H, Kumar N. In silico ADME, Bioactivity and Toxicity Parameters Calculation of Some Selected Anti-Tubercular Drugs. International Journal of Pharmaceutical and Phytopharmacological Research. 2016 Dec 30; 6(6):77-9.
10. Singh HP, Sharma CS, Mishra SS, Pandiya H, Kumar N. In silico ADME, Bioactivity and Toxicity Prediction of Some Selected Anti-Parkinson Agents. International Journal of Pharmaceutical and Phytopharmacological Research. 2017 Apr 17; 6(3):64-7.
11. Mishra SS, Sharma CS, Singh HP, Kumar N. In silico Pharmacokinetic and Toxicity Evaluation of Some Selected Nonsteroidal Anti-inflammatory and Antipyretic-Analgesic Agents. International Journal of Pharmaceutical Technology and Biotechnology. 2016; 3(3):33-8.
12. Kumar N, Mishra SS, Sharma CS, Singh HP, Kalra S. In silico binding mechanism prediction of benzimidazole based corticotropin releasing factor-1 receptor antagonists by quantitative structure activity relationship, molecular docking and pharmacokinetic parameters calculation. Journal of Biomolecular Structure and Dynamics. 2018 May 19; 36(7):1691-712.
13. Mishra SS, Kumar N, Sirvi G, Sharma CS, Singh HP, Pandiya H. Computational Prediction of Pharmacokinetic, Bioactivity and Toxicity Parameters of Some Selected Anti arrhythmic Agents. The Pharmaceutical and Chemical Journal. 2017; 4(5):143-146
14. Singh HP, Mishra SS, Sharma CS, Kumar N. Computational Analysis of Pharmacokinetic, Bioactivity and Toxicity Parameters of Some Selected Antihypertensive Agents. International Journal of Pharmaceutical Technology and Biotechnology. 2017; 4(2):10-16.
2. Price D, Fletcher M, Van Der Molen T. Asthma control and management in 8,000 European patients: the recognise Asthma and LInk to Symptoms and Experience (REALISE) survey. NPJ primary care respiratory medicine. 2014 Jun 12; 24:14009.
3. Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, Williams H, ISAAC Phase Three Study Group. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. The Lancet. 2006 Aug 26; 368(9537):733-43.
4. National Asthma Education, Prevention Program (National Heart, Lung, Blood Institute). Second Expert Panel on the Management of Asthma. Expert panel report 2: Guidelines for the diagnosis and management of asthma. DIANE Publishing; 1997.
5. O'Byrne PM, Cook D. Is nedocromil sodium effective treatment for asthma. European Respiratory Journal. 1993 Jan 1; 6(1):5-6.
6. Sharma CS, Mishra SS, Singh HP, Kumar N. In silico ADME and Toxicity Study of Some Selected Antineoplastic Drugs. International Journal of Pharmaceutical Sciences and Drug Research. 2016; 8(1):65-7.
7. Singh HP, Sharma CS, Mishra SS, Pandiya H, Kumar N. In silico ADME, Bioactivity and Toxicity Prediction of Some Selected Anti-Parkinson Agents. International Journal of Pharmaceutical and Phytopharmacological Research. 2017 Apr 17; 6(3):64-7.
8. Kumar N, Mishra SS, Sharma CS, Singh HP, Pandiya H. In silico Pharmacokinetic, Bioactivity and Toxicity Evaluation of Some Selected Anti-Ulcer Agents. International Journal of Pharmaceutical Sciences and Drug Research. 2017; 9(2):68-71.
9. Mishra SS, Sharma CS, Singh HP, Pandiya H, Kumar N. In silico ADME, Bioactivity and Toxicity Parameters Calculation of Some Selected Anti-Tubercular Drugs. International Journal of Pharmaceutical and Phytopharmacological Research. 2016 Dec 30; 6(6):77-9.
10. Singh HP, Sharma CS, Mishra SS, Pandiya H, Kumar N. In silico ADME, Bioactivity and Toxicity Prediction of Some Selected Anti-Parkinson Agents. International Journal of Pharmaceutical and Phytopharmacological Research. 2017 Apr 17; 6(3):64-7.
11. Mishra SS, Sharma CS, Singh HP, Kumar N. In silico Pharmacokinetic and Toxicity Evaluation of Some Selected Nonsteroidal Anti-inflammatory and Antipyretic-Analgesic Agents. International Journal of Pharmaceutical Technology and Biotechnology. 2016; 3(3):33-8.
12. Kumar N, Mishra SS, Sharma CS, Singh HP, Kalra S. In silico binding mechanism prediction of benzimidazole based corticotropin releasing factor-1 receptor antagonists by quantitative structure activity relationship, molecular docking and pharmacokinetic parameters calculation. Journal of Biomolecular Structure and Dynamics. 2018 May 19; 36(7):1691-712.
13. Mishra SS, Kumar N, Sirvi G, Sharma CS, Singh HP, Pandiya H. Computational Prediction of Pharmacokinetic, Bioactivity and Toxicity Parameters of Some Selected Anti arrhythmic Agents. The Pharmaceutical and Chemical Journal. 2017; 4(5):143-146
14. Singh HP, Mishra SS, Sharma CS, Kumar N. Computational Analysis of Pharmacokinetic, Bioactivity and Toxicity Parameters of Some Selected Antihypertensive Agents. International Journal of Pharmaceutical Technology and Biotechnology. 2017; 4(2):10-16.
Published
01-07-2018
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“IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY STUDY OF SOME SELECTED ANTI-ASTHMATIC AGENTS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 10, no. 4, July 2018, pp. 278-82, https://doi.org/10.25004/IJPSDR.2018.100411.
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Copyright (c) 2018 Shashank Shekhar Mishra, Neeraj Kumar, Hamendra Pratap Singh, Shashi Ranjan, Chandra Shekhar Sharma
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
“IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY STUDY OF SOME SELECTED ANTI-ASTHMATIC AGENTS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 10, no. 4, July 2018, pp. 278-82, https://doi.org/10.25004/IJPSDR.2018.100411.
