IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY EVALUATION OF SOME SELECTED ANTI-ULCER AGENTS
Abstract
Peptic ulcer is a major health burden that recognized as a group of upper gastro-intestinal tract disorders. The aim of the therapy is to provide relieve from pain and prevent ulcer complications. Therefore, it is essential to evaluate the drug-likeness and toxicity profile of existing drugs for developing new potent anti-ulcer agents. In this research work, we study the pharmacokinetic, toxicity and bioactivity profile of few selected anti-ulcer agents by In silico method. These research investigations provide the lead for the development of new anti-ulcer agents with lesser toxicity and more effectiveness.
Keywords:
GI tract (Gastro-intestinal tract), TPSA, GPCR ligand, Toxicity, Bioactivity.DOI
https://doi.org/10.25004/IJPSDR.2017.090205References
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2. Abraham DJ. Burger’s medicinal chemistry and drug discovery. Wiley-Interscience. 2003.
3. Sharma CS, Mishra SS, Singh HP, Kumar N. In silico ADME and Toxicity Study of Some Selected Antineoplastic Drugs. International Journal of Pharmaceutical Sciences and Drug Research. 2016; 8(1):65-7.
4. Lipinski CA. Lead-and drug-like compounds: the rule-of-five revolution. Drug Discovery Today: Technologies. 2004; 1(4):337-341.
5. Srimai V, Ramesh M, Parameshwar KS, Parthasarathy T. Computer-aided design of selective Cytochrome P450 inhibitors and docking studies of alkyl resorcinol derivatives. Medicinal Chemistry Research. 2013; 22(11):5314-5323.
6. Palm K, Stenberg P, Luthman, K, Artursson P. Polar molecular surface properties predict the intestinal absorption of drugs in humans. Pharmaceutical research. 1997; 14(5):568-571.
7. Sharma CS, Verma T, Singh HP, Kumar N. Synthesis, characterization and preliminary anticonvulsant evaluation of some flavanone incorporated semicarbazides. Medicinal Chemistry Research 2014; 23(11):4814-4824.
8. Verma A. Lead finding from Phyllanthus debelis with hepatoprotective potentials. Asian Pacific Journal of Tropical Biomedicine. 2012; 2(3): S1735-S1737.
Published
01-03-2017
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“IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY EVALUATION OF SOME SELECTED ANTI-ULCER AGENTS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 9, no. 2, Mar. 2017, pp. 68-71, https://doi.org/10.25004/IJPSDR.2017.090205.
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How to Cite
“IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY EVALUATION OF SOME SELECTED ANTI-ULCER AGENTS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 9, no. 2, Mar. 2017, pp. 68-71, https://doi.org/10.25004/IJPSDR.2017.090205.
